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| 1 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 2 | Toxic epidermal necrolysis and Stevens-Johnson syn- drome显示文摘 | Hart T French LE | 2010 | Orphanet J Rare Dis2010，5，： | 1 |
| 3 | Conditional partial volume correction for emission tomography: A wavelet-based hidden Markov model and multi-resolution approach 显示文摘 | Le P A Hart M Boussion N | 2008 | 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro2008，，： | 1 |
| 4 | 显示文摘 | Zhang Le Hart Pengde Wang Kun | 2012 | Journal of Alloys and Compounds2012，541，： | 1 |
| 5 | The relationship be- tween exercise and osteoarthritis in the elderly显示文摘 | Hart LE Haaland DA Baribeau DA | 2008 | Clin J Sport Med2008，18，： | 1 |
| 6 | The relationship between exercise and osteoarthritis in the elderly显示文摘 | Hart LE Haaland DA Baribeau DA | 2008 | Clin J Sport Med2008，18，： | 1 |
| 7 | Subacute neural stem cell therapy for traumatic brain injury 显示文摘 | Harting MT Sloan LE Jimenez F | 2009 | J Surg Res2009，153，2： | 1 |
| 8 | Ice for the treatment of acute soft - tissue injury : a review 显示文摘 | Hart LE | 2004 | Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine2004，14，5： | 1 |
| 9 | Toxic epidermal neerolysis and Stevens- Johnson syndrome 显示文摘 | Hart T French LE | 2010 | Orphanet J Rare Dis2010，5，2： | 1 |
| 10 | Still different after all these years:gender dif- ferences in professional identity formation显示文摘 | McGowen KP Hart LE | 1990 | Professional Psy-chology: Research and Practice1990，21，： | 1 |
| 11 | JNK regulation of oncogenesis显示文摘 | Heasley LE Hart SY | 2006 | Mol Ceils2006，21，2： | 1 |
| 12 | Subacute neural stem cell therapy for traumatic brain injury显示文摘 | Harting MT Sloan LE Jimenez F | | 0，，02： | 1 |
| 13 | Subacute neural stem cell thearapy for traumatic brain injuery显示文摘 | Harting MT Sloan LE Jimenez F | 2009 | J Surg Res2009，153，2： | 1 |
| 14 | Aerobic fitness and hormonal responses to prolonged sleep deprivation and sustained mental work显示文摘 | Radomski MW Hart LE Goodman JM | 1992 | Aviat Space Environ Med1992，63，2： | 1 |
| 15 | Fatty acid synthase inhibition activates AMP- activated protein kinase in SKOV3 human ovarian cancer cells 显示文摘 | Zhou W Hart WF Landree LE | 2007 | Cancer Res2007，67，7： | 1 |
| 16 | Development of NASA-TLX (Task Load Index):Results of Empirical and Theoretical Research显示文摘 | Hart SG Staveland LE | | 0，，1： | 1 |
| 17 | Toxic epidermal necrolysis and Stevens- Johnson syndrome显示文摘 | Hart T French LE | 2010 | Orphanet J Rare Dis2010，539，： | 1 |
| 18 | C-reactive protein and bacterial meningitis 显示文摘 | Cuevas LE Hart CA Molyneux M | 1988 | Ann Trop Pediatric1988，8，4： | 1 |
| 19 | Toxic epidermal necrolysis and Stevens- Johnson syndrome显示文摘 | Hart T French LE | 2010 | Orphanet J Rare Dis2010，16，5： | 1 |
| 20 | Meninqococcal disease in Africa显示文摘 | Hart CA Cuevas LE | 1997 | Ann Trop Med Parasitol1997，91，7： | 1 |
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