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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Evidence for de novo synthesis of cytokines and chemokines in platelet concentrates显示文摘 | HARTWIG D HARTEL C HENNIG H | 2002 | Vox Sang2002，82，： | 1 |
| 3 | A chimeric humanized single - chain antibody against the type 1 insulin - like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenie effects of IGF - 1 显示文摘 | SACHDEV D LI S L HARTELL J S | 2003 | Cancer Res2003，63，： | 1 |
| 4 | MEK/MAPK as a signaling element in ATP control of endothelial myosin light chain显示文摘 | Klingenberg D Gunduz D Hartel F | 2004 | Am J Physiol2004，286，4： | 1 |
| 5 | Evidence for de novo synthesis of cytokines and chemokines in platelet concentrates 显示文摘 | Hartwig D Hartel C Hennig H | 2002 | Vox Sang2002，82，4： | 1 |
| 6 | Mixtures of palm kernel oil with cocoa butter and milk fat in compound coatings显示文摘 | WILLIAMS S D RANSOM - PAINTER K L HARTEL R W | 1997 | J Am Oil Chem Soc1997，74，4： | 1 |
| 7 | A chimeric Homanized SingleChain Antibody against the Type Ⅰ Insulin-like Growth Factor (IGF) Receptor Renders Breast Cancer Cells Refractory to the Mitogenic Effects of IGF-1 显示文摘 | Li SL Hartell JS | 2003 | Cancer Res2003，63，3： | 1 |
| 8 | A chimeric humanized single chain antibody against the type Ⅰ insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of 1GF-Ⅰ显示文摘 | Sachdev D Li SL Hartell JS etal | 2003 | Cancer Res2003，63，3： | 1 |
| 9 | Clinical manifestations and predictors of disease progression in drug users with human immunodeficiency virus infection 显示文摘 | Selwyn PA Alcabes P Hartel D | 1992 | N Engl J Med1992，327，24： | 1 |
| 10 | Risk factors forhuman inununodeficieney virus io-feetion in intravenous drug users 显示文摘 | Schoenbaum EE Hartel D Selwyn PA | 1989 | NEnglJMed1989，321，13： | 1 |
| 11 | A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I显示文摘 | Sachdev D Li S L Hartell J S | 2003 | Cancer Research2003，63，： | 1 |
| 12 | The Trithorax group protein Ash21 and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation显示文摘 | Pullirsch D Hartel R Kishimoto H | 2010 | Development2010，137，6： | 1 |
| 13 | Accumulation of extra- cellular ATP protects against acute reperfusion injury in rat heart endothelial cells 显示文摘 | Gunduz D Kasseckert SA Hartel FV | 2006 | Cardiovasc Res2006，71，4： | 1 |
| 14 | HIV infection,drug use,and onset of natural menopause 显示文摘 | Schoenbaum EE Hartel D Lo Y | 2005 | Clin InfectDis2005，41，10： | 1 |
| 15 | A prospective study of therisk of tuberculosis among intravenous drug users with human im-munodeficiency virus infection显示文摘 | Selwyn PA Hartel D Lewis VA | 1989 | N Engl J Med1989，320，9： | 1 |
| 16 | Methadone treatment protects a- gainst HIV infection: two decades of experience in the Bronx, New York City 显示文摘 | Hartel D M Schoenbaum E E | 1998 | Public Health Rep1998，1131，： | 1 |
| 17 | Evolution of oestrogen functions in vertebrates显示文摘 | Lange I G Hartel A Meyer H H D | 2003 | J Steroid Biochem2003，83，： | 1 |
| 18 | Digalactosyldiacylg- lycerol synthesis in chloroplasts of the Arabidopsis dgdl mu- tant显示文摘 | Klaus D Hartel H Fitzpatrick L M | 2002 | Plant Physiology2002，128，3： | 1 |
| 19 | Risk factors forhuman immunodeficiency virus infection in intravenous drug users显示文摘 | Schoenbaum EE Hartel D Selwyn PA | 1989 | N Engl J Med1989，321，13： | 1 |
| 20 | A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells 显示文摘 | Sachdev D Hartell JS Lee AV | 2004 | J Biol Chem2004，279，6： | 1 |
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