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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Stentingversus surgery in patients with carotid stenosis afterprevious cervical radiation therapy : systematic reviewand meta-analysis显示文摘 | Fokkema M den Hartog AG Bots ML | 2012 | Stroke2012，43，3： | 1 |
| 3 | Effect of wheat cultivar and enzyme addition to broiler chicken diets on nutrient digestibility,performance,and apparent metabolizable energy content显示文摘 | Gutierrez del Alamo A Verstegen M W Den Hartog L A | 2008 | Poult Sci2008，87，4： | 1 |
| 4 | Application of the HACCP concept to improve the safety of street foods显示文摘 | Hartog B J Stoots J A M | 1992 | Food Lab News1992，8，2： | 1 |
| 5 | If You Are So Smart, Why Aren't You An Entrepreneur Returns to Cognitive and Social Ability: Entrepreneurs Versus Employees显示文摘 | Hartog J Van Praag M Van Der Sluis J | 2010 | Journal of Economics & Management Strategy2010，19，4： | 1 |
| 6 | Gestational diabetes-practical approach in the clinic显示文摘 | Lapaire O Huhn E Hartog M | 2008 | Ther Umsch2008，65，11： | 1 |
| 7 | Molecular identification of the api- cal Ca2+channel in 1,25-dihydroxyvitamin Dz-respon- sive epithelia 显示文摘 | HOENDEROP J G VAN DER KEMP A W C M HARTOG A | 1999 | The Journal of Biological Chemis- try1999，274，13： | 1 |
| 8 | Distributed temperature sensing in solid-core fibres 显示文摘 | Hartog A Leach A Gold M | 1985 | Electronics Letters1985，21，23： | 1 |
| 9 | Gestational diabetes practical ap- proach in the clinic 显示文摘 | Lapaire O Huhn E Hartog M | 2008 | Ther Umsch2008，65，11： | 1 |
| 10 | Rela-tionship between allergic rhinitis,disturbed cognitive functions and psychological well being显示文摘 | KREMER B DEN HARTOG H M JOLLES J | 2002 | Clin Exp Allergy2002，32，： | 1 |
| 11 | The Arabidopsis somatic embryogenesis receptor kinase 1 gene is expressed in developing ovules and embryos and enhances embryogenic competence in culture显示文摘 | Hecht V Vielle-Calzada J P Hartog M V | 2001 | Plant Physiol2001，127，： | 1 |
| 12 | Distributed temperature sensor in solid-core fibers显示文摘 | Hartog A H Leach A P Gold M P | 1985 | Electron Lett1985，21，23： | 1 |
| 13 | Air pollution from traffic in city districts near major motorways显示文摘 | ROORDA-KNAPE M C JANSSEN N A H HARTOG J J D | 1998 | Atmos Environ1998，32，11： | 1 |
| 14 | Cognitive functioning in young and middle-aged unmediated out-patients with major depression: testing the effort and cognitive speed hypotheses 显示文摘 | DEN HARTOG H M DERIX M M VAN BENMMEL A L | 2003 | Psychol Med2003，33，： | 1 |
| 15 | The efficacy and safety of colloid resuscitation in the critically ill显示文摘 | Hartog CS Bauer M Reinhart K | | 0，，： | 1 |
| 16 | The Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1 gene is expressed in developing ovules and embryos and enhances embryogenic competence in cuhure显示文摘 | Hecht V Vielle-Calzada J P Hartog M V et ol | 2001 | Plant Physiology2001，127，3： | 1 |
| 17 | Distributed temperature sensors in solid-core fiber 显示文摘 | Hartog A H Leach A P Gold M P | 2000 | Electron Lett2000，21，12： | 1 |
| 18 | Distributed Temperature Sensor in Solid-Core Fiber显示文摘 | Hartog A Leach A Gold M | 2000 | Electron Lett2000，21，12： | 1 |
| 19 | Nod factorinduced phosphatidic acid and diacylglycerol pyrophosphate formation : a role for phospholipase C and D in root hair deformation显示文摘 | den Hartog M Musgrave A Munnik T | 2001 | Plant J2001，25，： | 1 |
| 20 | Losartan reduces aortic dilatation rate in adults with Marfan syndrome:a randomized controlled trial 显示文摘 | GROENINK M DEN HARTOG A W FRANKEN R | 2013 | Eur Heart J2013，34，45： | 1 |
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