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| 1 | Effects of binder strength and aggregate size on the compressive strength and void ratio of porous concrete显示文摘To test the influence of binder strength, porous concretes with 4 binder strengths between 30.0-135.0 MPa and 5 void ratios between 15%-35% were tested. The results indicated that for the same aggregate, the rates of strength reduction due to the increases in void ratio were the same for binders with different strengths. To study the influence of aggregate size, 3 single size aggregates with nominal sizes of 5.0, 13.0 and 20.0 mm (Nos. 7, 6 and 5 according to JIS A 5001) were used to make porous concrete. The strengths of porous concrete are found to be dependent on aggregate size. The rate of strength reduction of porous concrete with small aggregate size is found to be higher than that with larger aggregate size. At the same void ratio, the strength of porous concrete with large aggregate is larger than that with small aggregate. The general equations for porous concrete are related to compressive strength and void ratio for different binder strengths and aggregate sizes. | P. Chindaprasirt S. Hatanaka N. Mishima Y. Yuasa T. Chareerat | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，6： | 22 |
| 2 | Balloon-occluded transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘Transcatheter arterial chemoembolization(TACE) is widely accepted as a treatment for patients with hepatocellular carcinoma(HCC) in the intermediate stage according to the Barcelona Clinic Liver Cancer(BCLC) guidelines. Recently, balloon-occluded TACE(B-TACE) was developed in Japan. Despite the lack of a clear definition, B-TACE is generally defined as the infusion of emulsion of chemotherapeutic agents with lipiodol followed by gelatin particles under the occlusion of feeding arteries by a microballoon catheter, which leads to the dense lipiodol emulsion(LE) accumulation in HCC nodules. This phenomenon cannot be explained only by the prevention of proximal migration and leakage of embolization materials; it further involves causing local changes in the hemodynamics of the surrounding occlusion artery and targeted HCC nodules. Balloon-occluded arterial stump pressure plays an important role in the dense LE accumulation in targeted HCC nodules. Although randomized controlled trials comparing the therapeutic effect and the prognosis of B-TACE to those of the other TACE procedures, such as conventional-TACE and drug-eluting beads TACE, are still lacking, B-TACE is thought to be a promising treatment. The purpose of this review is to summarize the mechanism, therapeutic effect, indication, prognosis and complications of BTACE. | Takeshi Hatanaka Hirotaka Arai Satoru Kakizaki | 2018 | World Journal of Hepatology2018，10，7： | 22 |
| 3 | 高灵敏度的涂层破损探测系统──MS迈克尔显示文摘开发了地下管线涂层破损探测系统。通过采用随机信号模拟探测信号,明显地减少了来自外部的杂音影响,探测灵敏度得以提高。挖开、检查地下管线涂层破损处也证实,该系统的探测灵敏度是相当高的。 | Shozo Hatanaka 张守本 | 2001 | 国外油田工程2001，17，6： | 2 |
| 4 | Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction显示文摘In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases.However,it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state.Here,we describe a versatile in vivo gene knock-in methodology that enables the targeting of a broad range of mutations and cell types through the insertion of a minigene at an intron of the target gene locus using an intracellularly linearized single homology arm donor.As a proof-of-concept,we focused on a mouse model of prematureaging caused by a dominant point mutation,which is difficult to repair using existing in vivo genome-editing tools.Systemic treatment using our new method ameliorated aging-associated phenotypes and extended animal lifespan,thus highlighting the potential of this methodology for a broad range of in vivo genome-editing applications. | Keiichiro Suzuki Mako Yamamoto Reyna Hernandez-Benitez Zhe Li Christopher Wei Rupa Devi Soligalla Emi Aizawa Fumiyuki Hatanaka Masakazu Kurita Pradeep Reddy Alejandro Ocampo Tomoaki Hishida Masahiro Sakurai Amy NNemeth Estrella Nunez Delicado Josep MCampistol Pierre Magistretti Pedro Guillen Concepcion Rodriguez Esteban Jianhui Gong Yilin Yuan Ying Gu Guang-Hui Liu Carlos Lopez-Otin Jun Wu Kun Zhang Juan Carlos Izpisua Belmonte | 2019 | Cell Research2019，29，10： | 2 |
| 5 | αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model显示文摘Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular organisms.Their regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with age.During aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016). | Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2020 | Protein & Cell2020，11，3： | 2 |
| 6 | Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction显示文摘Pancreatic ductal adenocarcinoma(PDAC) has the poorest prognosis of all malignancies and is largely resistant to standard therapy. Novel treatments against PDAC are desperately needed. Anti-Gal is the most abundant natural antibody in humans,comprising about 1% of immunoglobulins and is also naturally produced in apes and Old World monkeys. The anti-Gal ligand is a carbohydrate antigen called 'α-gal epitopes' with the structure Galα1-3Galβ1-4Glc NAc-R. These epitopes are expressed as major carbohydrate antigens in non-primate mammals,prosimians,and New World monkeys. Anti-Gal is exploited in cancer vaccines to increase the immunogenicity of antigen-presenting cells(APCs). Cancer cells or PDAC tumor lysates are processed to express α-gal epitopes. Vaccination with these components results in in vivo opsonization by anti-Gal Ig G in PDAC patients. The Fc portion of the vaccine-bound anti-Gal interacts with Fcγ receptors of APCs,inducing uptake of the vaccine components,transport of the vaccine tumor membranes to draining lymph nodes,and processing and presentation of tumor-associated antigens(TAAs). Cancer vaccines expressing α-gal epitopes elicit strong antibody production against multiple TAAs contained in PDAC cells and induce activation of multiple tumor-specific T cells. Here,we review new areas of clinical importance related to the α-gal epitope/anti-Gal antibody reaction and the advantages in immunotherapy against PDAC. | Masahiro Tanemura Eiji Miyoshi Hiroaki Nagano Hidetoshi Eguchi Katsuyoshi Matsunami Kiyomi Taniyama Nobutaka Hatanaka Hiroki Akamatsu Masaki Mori Yuichiro Doki | 2015 | World Journal of Gastroenterology2015，21，40： | 2 |
| 7 | Clinical implication of interleukin(IL)-10 induced by non-small cell lung cancer显示文摘 | Hatanaka H Abe Y Kamiya T | 2000 | Ann Qncol2000，11，： | 1 |
| 8 | Cement paste characteristics and porous concrete properties显示文摘 | CHINDAPRASIRT P HATANAKA S CHAREERAT T | 2008 | Construction and Building Materials2008，，22： | 1 |
| 9 | Postmortem changes in cytochrome c oxidase activity in various organs of the rat and in human heart显示文摘 | Ikegaya H Iwase H Hatanaka K | 2000 | Forensic Sci Int2000，108，3： | 1 |
| 10 | Reversal of cisplatin and multidrug resistance by ribozyme-mediated glutathione suppression 显示文摘 | Nagata J Kijima H Hatanaka H | 2001 | Biochem Biophys Res Commun2001，286，2： | 1 |
| 11 | One-pot synthesis of optically active cyanohydrin acetates from aldehydes via quinidine-catalyzed transhydrocyanation coupled with lipase-catalyzed kinetic resolution in organic solvent 显示文摘 | Inagaki M Hatanaka A Mimura M Hiratake J Nishioka T Oda J | 1992 | Bull Chem Soc Jpn1992，65，1： | 1 |
| 12 | Apolipoproteins A Ⅰand A Ⅱ downregulate neutrophil functions 显示文摘 | Furlaneto C J Ribeiro FP Hatanaka E | 2002 | Lipids2002，37，9： | 1 |
| 13 | Passivity-based pose synchronization in three dimensions显示文摘 | Hatanaka T Igarashi Y Fujita M | 2012 | IEEE Trans on Automatic Control2012，7，2： | 1 |
| 14 | Serum amyloid A induces CCL20 secretion in mononuclear cells through MAPK(p38 and ERK1/2)signaling pathways显示文摘 | Sandri S Hatanaka E Franco AG | 2008 | Immunology Letters2008，121，1： | 1 |
| 15 | Study of thermo- oxidative degradation of molten state polypropylenes with a variety of tacticities 显示文摘 | HATANAKA T MORI H TERANO M | 1999 | Polym Degrad Stab1999，64，2： | 1 |
| 16 | Expansion of GSI' s Nationwide GPS Array 显示文摘 | Miyazaki S Saito T Sasaki M Hatanaka Y Iimura Y | 1997 | Bulletin of Geographical Survey Institute1997，43，： | 1 |
| 17 | Effects of embossing and restoration process on the deep drawability of aluminum alloy sheets 显示文摘 | NAMOCO C S IIZUKA T HATANAKA N TAKAKURA N YAMAGUCHI K | 2007 | Journal of Materials Processing Technology2007，，： | 1 |
| 18 | Clinical implications of interleukin-10 induced by non-small cell lung cancer 显示文摘 | Hatanaka H Abe Y Kamiya T | 2000 | Ann Oncol2000，11，7： | 1 |
| 19 | Extraction and purification of pectic polysaccharide from soybean okara and enzymatic analysis of their structures显示文摘 | Yamaguchi F Ota Y Hatanaka C | 1996 | Carbohydrate Poly-mers1996，30，4： | 1 |
| 20 | Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere显示文摘 | Enokido Y Hatanaka H | 1993 | Neuriscience1993，57，4： | 1 |
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