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| 1 | Paradoxical reduction of cerebral blood flow after acetazolamide loading:a hemodynamic and metabolic study with ^(15)O PET显示文摘Paradoxical reduction of cerebral blood flow(CBF)after administration of the vasodilator acetazolamide is the most severe stage of cerebrovascular reactivity failure and is often associated with an increased oxygen extraction fraction(OEF).In this study,we aimed to reveal the mechanism underlying this phenomenon by focusing on the ratio of CBF to cerebral blood volume(CBV)as a marker of regional cerebral perfusion pressure(CPP).In 37patients with unilateral internal carotid or middle cerebral arterial(MCA)steno-occlusive disease and8 normal controls,the baseline CBF(CBF_b),CBV,OEF,cerebral oxygen metabolic rate(CMRO_2),and CBF after acetazolamide loading in the anterior and posterior MCA territories were measured by^(15)O positron emission tomography.Paradoxical CBF_b reduction was found in 28 of 74 regions(18of 37 patients)in the ipsilateral hemisphere.High CBF_b(>47.6 mL/100 mL/min,n=7)was associated with normal CBF_b/CBV,increased CBV,decreased OEF,and normal CMRO_2.Low CBF_b(<31.8 mL/100mL/min,n=9)was associated with decreased CBF_b/CBV,increased CBV,increased OEF,and decreased CMRO_2.These findings demonstrated that paradoxical CBF reduction is not always associated with reduction of CPP,but partly includes highCBF_b regions with normal CPP,which has not been described in previous studies. | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Mitsuaki Tatsumi Kazuo Kitagawa Toshiyuki Fujinaka Toshiki Yoshimine Jun Hatazawa | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 2 | Oscillatory Flow in Thermoacoustic Sound Wave Generator显示文摘在一个 thermoacoustic 声波发电机的摆动的流动被描述。thermoacoustic 声波发电机在 thermoacoustic 设备起一个重要作用。在工作液体的工作液体和栈,加速和减速之间的热交换并且粘滞在栈并且在回声试管影响的磨擦损失 thermoacoustic 声波生成器的性能。特别地,摆动的流动显著地影响在工作液体和栈之间的热交换机制。在压力和速度的时间的变化是在回声试管内的正弦曲线。流动就在试管插头后面形成一口摆动的喷气,并且在回声试管外面下游地远变得断断续续。0.63R 的无限制的修正,也就是说尽管有在试管插头外面,被速度大小证实并且流动,摆动的流动特征下游地被维持的区域可视化。另外,他们几乎等于听觉的理论结果。关键词 thermoacoustic 现象 - 声波生成器 - 摆动的流动 CLC 数字 TK11. | Masayasu HATAZAWA | 2006 | Journal of Thermal Science2006，15，1： | 2 |
| 3 | CBF/CBV maps in normal volunteers studied with ^(15)O PET:a possible index of cerebral perfusion pressure显示文摘Local cerebral perfusion pressure(CPP) is a primary factor controlling cerebral circulation and previous studies have indicated that the ratio of cerebral blood flow(CBF) to cerebral blood volume(CBV) can be used as an index of the local CPP. In this study,we investigated whether the CBF/CBV ratio differs among different brain structures under physiological conditions, by means of O positron emission tomography. Nine healthy volunteers(5 men and 4women, mean age,47.0 ±1.2 years) were studied by H2 O bolus injection for CBF measurement and by C O inhalation for CBV measurement. The CBF/CBV ratio maps were created by dividing the CBF images by the CBV images after anatomical normalization.Regions of interest were placed on the CBF/CBV maps and comparing the regions. The mean CBF/CBV ratio was highest in the cerebellum(19.3 ± 5.2/min)' followed by the putamen(18.2 士 3.9), pons(16_4 土 4.6)' thalamus(14.5 土 3.3), cerebral cortices(13.2 土 2.4), and centrum semiovale(11.5 土 2.1).The cerebellum and putamen showed significantly higher CBF/CBV ratios than the cerebral cortices and centrum semiovale. We created maps of the CBF/CBV ratio in normal volunteers and demonstrated higher CBF/CBV ratios in the cerebellum and putamen than in the cerebral cortices and deep cerebral white matter. The CBF/CBV may reflect the local CPP and should be studied in hemodynamically compromised patients and in patients with risk factors for small-artery diseases of the brain. | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Jun Hatazawa | 2014 | Neuroscience Bulletin2014，30，5： | 2 |
| 4 | Cerebral blood volume in acute brain infarction: a combined study with dynamic susceptibility contrast MRI and 99mTc HMPAO SPECT显示文摘 | Hatazawa J Shimosegawa E Toyoshima H | 1999 | Stroke1999，30，2： | 1 |
| 5 | Clinical positron emission tomography for brain tumors:comparison of fludeoxyglucose F 18 and L-methyl-11C-methionine显示文摘 | Ogawa T Inugami A Hatazawa J | 1996 | AJNR Am J Neuroradiol1996，17，2： | 1 |
| 6 | An electrostatic top motor and its characters 显示文摘 | Sakata M Hatazawa Y Omodaka A | 1990 | Solid-State Sensors and Actuators1990，，2： | 1 |
| 7 | Preconditioning stress prevents cold restraint stress-induced gastric lesions in rats:roles of COX-1,COX-2,and PLA显示文摘 | Tanalm A Hatazawa R Takahira Y | 2007 | Dig Dis Sci2007，52，2： | 1 |
| 8 | Role of endogenous nitric oxide(No)and NO synthasea in healing of indomethacin-induced intestinal ulcers in rats显示文摘 | Takeuchi K Hatazawa R Tanigami M | 2007 | Life Sci2007，80，4： | 1 |
| 9 | Relationship between cerebral circulatory reserve and oxygen extraction fraction in patients with major cerebral artery occlusive disease: a positron emission tomography study显示文摘 | Yata K Suzuki A Hatazawa J | 2006 | Stroke2006，37，2： | 1 |
| 10 | Is adenomyosis an immune disease?显示文摘 | Ota H Igarashi S Hatazawa J | 1998 | Hum Reprod Update1998，4，4： | 1 |
| 11 | The performance of general-purpose colour CRT monitors in PACS environment显示文摘 | Hatazawa K Kozuka T | 2001 | Computer Methods and programs in Biomedicine2001，66，1： | 1 |
| 12 | Cerebral blood volume in acute brain infarction: a combined study with dynamic susceptibility contrast MRI and 99TCm-HMPAO-SPECT显示文摘 | Hatazawa J Shimosegawa E Toyoshima H | 1999 | Stroke1999，30，4： | 1 |
| 13 | Clinical positron emission tomography for brain tumors:comparison of fludeoxyglucose F18 and L-methyl-11C-methionine显示文摘 | Inugami A Hatazawa J | 1996 | AJNR1996，17，2： | 1 |
| 14 | Subcorticalhypoperfusion associated with asymptomatic white matterlesions on magnetic resonance imaging显示文摘 | Hatazawa J Shimosegawa E Satoh T | 1997 | Stroke1997，28，10： | 1 |
| 15 | Detection of deoxy- genation related signal change in acute ischemic stroke patients by T *-weighted magnetic resonance imaging显示文摘 | Tamura H Hatazawa J Toyoshima H | 2002 | Stroke2002，33，4： | 1 |
| 16 | Distribution of heat shock proteins in eutopic and ectopic endometrium in endometriosis and adenomyosis显示文摘 | Ota H Igarashi S Hatazawa J Tanaka T | 1997 | Fertil Steril1997，68，： | 1 |
| 17 | Subcortical hypoperfusion associated with asymptomatic white matter lesions on magnetic resonance imaging显示文摘 | Hatazawa J Shimosegawa E Satoh T | 1997 | Stroke1997，28，10： | 1 |
| 18 | Metabolic penumbra of acute brain infarction : Correlation with infarct growth 显示文摘 | Shimosegawa E Hatazawa J Ibaraki M | 2005 | Ann Neurol2005，57，4： | 1 |
| 19 | Role of positron emission tomography with 2-deoxy-2-[ 18 F]fluoro-d-glucose in evaluating the effects of arterial infusion chemotherapy and radiotherapy on pancreatic cancer显示文摘 | Masato Yoshioka Tsutomu Sato Tomoki Furuya Satoshi Shibata Hideaki Andoh Yoshihiro Asanuma Jun Hatazawa Eku Shimosegawa Kenji Koyama Yuzo Yamamoto | 2004 | Journal of Gastroenterology2004，，1： | 1 |
| 20 | Lowered cerebral glucose utilization in amyotrophic lateral sclerosis显示文摘 | Hatazawa J Brooks RA | 1987 | Ann Neurol1987，22，5： | 1 |
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