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| 1 | Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage显示文摘Brain-derived neurotrophic factor(BDNF) regulates many neurological functions and plays a vital role during the recovery from central nervous system injuries. However, the changes in BDNF expression and associated factors following hypoxia-ischemia induced neonatal brain damage, and the significance of these changes are not fully understood. In the present study, a rat model of hypoxic-ischemic brain damage was established through the occlusion of the right common carotid artery, followed by 2 hours in a hypoxic-ischemic environment. Rats with hypoxic-ischemic brain damage presented deficits in both sensory and motor functions, and obvious pathological changes could be detected in brain tissues. The m RNA expression levels of BDNF and its processing enzymes and receptors(Furin, matrix metallopeptidase 9, tissuetype plasminogen activator, tyrosine Kinase receptor B, plasminogen activator inhibitor-1, and Sortilin) were upregulated in the ipsilateral hippocampus and cerebral cortex 6 hours after injury;however, the expression levels of these m RNAs were found to be downregulated in the contralateral hippocampus and cerebral cortex. These findings suggest that BDNF and its processing enzymes and receptors may play important roles in the pathogenesis and recovery from neonatal hypoxic-ischemic brain damage. This study was approved by the Animal Ethics Committee of the University of South Australia(approval No. U12-18) on July 30, 2018. | Liu-Lin Xiong Jie Chen Ruo-Lan Du Jia Liu Yan-Jun Chen Mohammed Al Hawwas Xin-Fu Zhou Ting-Hua Wang Si-Jin Yang Xue Bai | 2021 | Neural Regeneration Research2021，16，8： | 12 |
| 2 | Structural basis for thermost-ability revealed through the identification and characterization of a highly thermostable phosphotriesterase-like lactonase from Geobac-illus stearothermophilus显示文摘 | Hawwa R Aikens J Turner RJ | 2009 | Arch Biochem Biophys2009，488，2： | 1 |
| 3 | Ranolazine:clinical applications and therapeutic basis显示文摘 | Hawwa N Menon V | 2013 | Am J Cardiovasc Drugs2013，13，1： | 1 |
| 4 | A perfusion technique for the determination of pro - inflammatory mediators induced by intradental application of irritants 显示文摘 | Chidiac JJ Hawwa N Baliki M | 2001 | J Pharmacol Toxicol Methods2001，46，3： | 1 |
| 5 | Methotrexate polyglutamates as a potential marker of adherence to long - term therapy in children with juvenile idiopathic arthritis and juvenile dermatomyositis: an observational, cross - sectional study 显示文摘 | HAWWA A F ALBAWAB A ROONEY M | 2015 | Arthritis Res Ther2015，17，1： | 1 |
| 6 | Potential risk factors for medication non-adherence in patients with chronic obstructive pulmonary disease (COPD) 显示文摘 | Khdour M R Hawwa A F Kidney J C | 2012 | Eur J Clin Pharmacol2012，68，10： | 1 |
| 7 | Influence of ABCBI polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant显示文摘 | Hawwa AF McKiernan PJ Shields M | 2009 | Br J Clin Pharmacol2009，68，3： | 1 |
| 8 | Potential risk factors for medication non-adherence in patients with chronic obstructive pulmonary disease (COPD)显示文摘 | Khdour MR Hawwa AF Kidney JC | 2012 | Eur J Clin Pharmacol2012，68，10： | 1 |
| 9 | Ranolazine: clinical applications and thcrapeutic basis显示文摘 | Hawwa N Menon V | 2013 | Am J Cardiovasc Drugs2013，13，1： | 1 |
| 10 | Audio Mixing for Centralized Conference in a SIP Environment显示文摘 | Samer Hawwa | 2002 | IEEE2002，，： | 1 |
| 11 | The localization of buckling modes in nearly periodic trusses显示文摘 | Brasil R M Hawwa M A | 1995 | Computers & Structures1995，56，6： | 1 |
| 12 | Development and validation of an HPLC method for the rapid and simultaneous determination of 6-mercaptopurine and four of its metabolites in plasma and red blood cells显示文摘 | Hawwa A F Millership J S Collier P S | | 0，，： | 1 |
| 13 | IL-10 inhibits inflammatory cytokines released by fetal mouse lung fibre- blasts exposed to mechanical stretch 显示文摘 | Hawwa RL Hokenson MA Wang Y | 2011 | Pediatr Pul- monol2011，46，7： | 1 |
| 14 | Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxieity and dosage requirements in children with liver transplant显示文摘 | Hawwa AF McKieman PJ Shields M | 2009 | Br J Clin Pharmacol2009，68，3： | 1 |
| 15 | Pharmacogenomic studies of the anticancer and immtmosuppressive thiopurines mercaptopurine and azathioprine显示文摘 | HAWWA A F MILLERSHIP J S COLLIER P S | 2008 | Br J Clin Pharmacol2008，66，4： | 1 |
| 16 | A Nonlinear PID Control Scheme for Hard Disk Drive Servosystems显示文摘 | BASEL M ISAYED MUHAMMAD A HAWWA | 2007 | Control and Automation2007，，07： | 1 |
| 17 | The localization of buckling modes in nearly periodic trusses显示文摘 | Hawwa M A | 1995 | Computers & Structures1995，56，6： | 1 |
| 18 | IL-10 inhibits in- flammatory cytokines released by fetal mouse lung fibroblasts exposed to mechanical stretch 显示文摘 | Hawwa RL Hokenson MA Wang Y | 2011 | Pediatr Pulmonol2011，46，7： | 1 |
| 19 | Chaotic behavior of a curved carbon nanotube under harmonic excitation显示文摘 | Mayoof F N Hawwa M A | | 0，，： | 1 |
| 20 | Phar- macogenomie studies of the anticancer and immuno- suppressive thiopurines mereaptopurine and azathio- prine显示文摘 | Hawwa AF Millership JS Collier PS | 2008 | Br J Clin Pharmacol2008，66，4： | 1 |
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