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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Effects of an endoscope on peristaltic flow of a micropolar fluid显示文摘 | Hayat T Ali N | 2008 | Mathe- matical and Computer ModeUing2008，48，55： | 1 |
| 3 | Statistical algorithm for nonuniformity correction in focal-plane arrays显示文摘 | Hayat M M Torres S N Armstrong E E | 1999 | Applied Optics1999，38，： | 1 |
| 4 | Statistical algorithm for nonuniformity correction in focal plane arrays显示文摘 | Hayat M M Tortes S N Armstrong E | 1999 | Applied Optics1999，38，： | 1 |
| 5 | Unsteady flow of a second grade fluid between two side walls perpendicular to a plate 显示文摘 | Fetecau C Hayat T Ali N | 2008 | Nonlinear Analysis : Real World Applications2008，9，3： | 1 |
| 6 | MHD flow and mass transfer of an upper-convected Maxwell fluid past a porous shrirddng sheet with chemical reaction species显示文摘 | Hayat T Abbas Z Ali N | 2008 | Phy Lett A2008，372，26： | 1 |
| 7 | Cancer statistics, trends, and multiple primary cancer analyses from the surveillance, epidemiology, and end results (seer) program 显示文摘 | Hayat M J Howlader N Reichman ME | 2007 | Oncologist2007，12，： | 1 |
| 8 | Cancer statistics, trends, and multiple primary cancer analysis from the surveillance, epidemiology, and end results (SEER) program 显示文摘 | Hayat MJ Howlader N Reichman ME | 2007 | Oncologist2007，12，1： | 1 |
| 9 | Cancer statistic, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program 显示文摘 | Hayat M J Howlader N Reichman ME | 2007 | Oncologist2007，12，1： | 1 |
| 10 | Kalman filtering for adaptive nonuniformity correction in infrared focal-plane arrays显示文摘 | Tortes S N Hayat M M | 2003 | The Optical SocieO of America A2003，20，： | 1 |
| 11 | Effect of feeding flax and two types of antioxidants on egg pro- duction, egg quality, and lipid composition of eggs 显示文摘 | HAYAT Z CHERIAN G PASHA T N | 2009 | The Journal of Applied Poultry Research2009，18，3： | 1 |
| 12 | Cancer statistics,trends,and multiple primary cancer analyses from the Surveillance,Epidemiology,and End Results (SEER) Program显示文摘 | Hayat MJ Howlader N Reichman ME | | 0，，： | 1 |
| 13 | A mathematical description of peristaltic hydromagnetic flow in a tube显示文摘 | Hayat T Ali N | 2007 | Applied Mathematics and Computation2007，18，2： | 1 |
| 14 | Cancer statistics, trends, and multiple primary cancer analyses from the Surveil- lance, Epidemiology, and End Results (SEER) Program显示文摘 | Hayat MJ Howlader N Reichman ME | 2007 | On- cologist2007，12，1： | 1 |
| 15 | Peristaltic flow of a micropolar fluid in an asymmetric channel显示文摘 | Ali N Hayat T | 2008 | Comput-ers&Mathem atics With Applications2008，55，4： | 1 |
| 16 | Statistical algorithm for nonuniformity correction ip focalplane arrays 显示文摘 | Hayat Majeed M Torres Sergio N Armstrong Ernest | 1999 | Applied Optics1999，38，8： | 1 |
| 17 | Statistical Al-gorithm for Non-uniformity Correction in Focal-Plane Arrays 显示文摘 | M M Hayat S N Torres E E Armstrong | 1999 | OSA Applied Optics1999，538，： | 1 |
| 18 | Tool and lubrication for negative incremental forming of a Commercially pure titanium sheet 显示文摘 | Hussain G Gao L Hayat N | 2008 | Journal of Materials Processing Technology2008，203，123： | 1 |
| 19 | Exact peristaltic flow in tubes with an endoscope 显示文摘 | Hayat T Ali N Asghar S Siddiqui A M | 2006 | Applied Mathematics and Computation2006，182，1： | 1 |
| 20 | An analysis of peristaltic transport for flow of a Jeffrey fluid 显示文摘 | Hayat T Ali N Asghar S | 2007 | Acta Mechanica2007，193，12： | 1 |
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