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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | A prospective study of the effect of haemorrhoideetomy on sphincter function and faecal continence显示文摘 | Read N W Haynes W G | 1982 | Br J Surg1982，69，7： | 1 |
| 3 | Continuous-mixtures vapor-liquid equilibria computations based on true boiling point distillations 显示文摘 | HAYNES H W MATHEWS M A | 1991 | Ind Eng Chem Res1991，30，： | 1 |
| 4 | Total domination subdivision numbers of trees显示文摘 | Haynes T W Henning M A Hopkins L | 2004 | Discrete Mathematics2004，286，： | 1 |
| 5 | Failure of femoral head fixation:a cadaveric analysis of lag screw cut-out with the gamma locking nail and AO dynamic hip screw显示文摘 | Haynes R C Poll R G Miles A W | | 0，，5： | 1 |
| 6 | Plasma endothelin following cardiac arrest : differences between aurvivors and nonsuvivors 显示文摘 | Haynes W Hamer DW Robertson CE | 1994 | Resuscitation1994，27，： | 1 |
| 7 | Leptin and the central neural mech-anisms of obesity hypertension显示文摘 | Rahmouni K G Haynes W | 2002 | Drugs Today(Barc)2002，38，12： | 1 |
| 8 | Thermal cycling behavior of plasma-sprayed thermal barrier coatings with various MCrAIX bond coats显示文摘 | Haynes J A Ferber M K Porter W D | | 0，，01： | 1 |
| 9 | A surgical safety checklist to reduce morbidity and mortality in a global population显示文摘 | Haynes A B Weiser T G Berry W R | 2009 | N Engl J Med2009，360，5： | 1 |
| 10 | Acquisition of Additional Equity Capital bySmall Firms - Findings fro in the National Survey of Small BusinessFinances 显示文摘 | OU C HAYNES G W | 2006 | Small Business Economics2006，27，： | 1 |
| 11 | Thermal cycling behavior of plasma-sprayed thermal barrier coatings with various McrAlX bond coats显示文摘 | HAYNES J A FERBER M K PORTER W D | 2000 | Journal of Thermal Spray Technology2000，9，： | 1 |
| 12 | Total Domination Critical and Stable Graphs upon Edge Removal 显示文摘 | DESORMEAUX W J HAYNES T W HENNING M A | 2010 | Discrete Applied Mathematics2010，158，： | 1 |
| 13 | Periodontal disease and a- therosclerosis: from dental to arterial plaque 显示文摘 | HAYNES W G STANFORD C | 2003 | Arterioscler Thromb Vasc Biol2003，23，8： | 1 |
| 14 | Estimating ecological integrity in the interior Columbic River basin显示文摘 | Quigley T M Haynes R W Hann W J | | 0，，1： | 1 |
| 15 | Leptin and the central neural mechanisms of obesity hypertension 显示文摘 | Rahmouni K G Haynes W | 2002 | Drugs Today2002，38，12： | 1 |
| 16 | Leptin, obesity and cardiovascular disease显示文摘 | Correia M L Haynes W G | 2004 | Curr Opin Nephrol Hypertens2004，13，2： | 1 |
| 17 | First Observation of Elliptical Sheet Beam Formation with an Non-Symmetric Solenoid Lens显示文摘 | Russell S J Wang Z-F Haynes W B | 2005 | Physical Review Special Topics-Accelerators and Beams2005，0804，： | 1 |
| 18 | A 500 MW, 1 μs pulse length high current relative klystron显示文摘 | Fazio M V Haynes W B Carlsten B E | 1994 | IEEE1994，22，5： | 1 |
| 19 | Enzymatic hydrolysis of wheat straw after steam pretreatment: experimental date and kinetic model显示文摘 | B Nidetzky W Steiner M Hayn | 1993 | Bioresource Technology1993，44，： | 1 |
| 20 | Receptor-mediated regional sympathetic nerve activation by leptin显示文摘 | Haynes W G Morgan D A Walsh S A | 1997 | J Clin Invest1997，100，2： | 1 |
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