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	题名	作者	年代	出处	被引量
1	Effect of lamivudine treatment on plasma levels of transforming growth factor β_1,tissue inhibitor of metalloproteinases-1 and metalloproteinase-1 in patients with chronic hepatitis B显示文摘AIM: Transforming growth factor (TGF)-β1, metalloproteinase (MMP)-1 and its tissue inhibitor (TIMP)-I are considered predictive biomarkers of chronic hepatitis activity and fibrosis.The aim of this study was to evaluate the effect of lamivudine treatment on the plasma levels of these peptides in patients with chronic hepatitis B.METHODS: TGF-β1, MMP-1 and TIMP-1 plasma concentrations were measured with an enzyme immunoassay in 40 patients treated with lamivudine for 48 wk. Elimination of HBV-DNA and HBV antigens was evaluated 24 wk after treatment completion.RESULTS: Baseline TGF-β1(29.6±2.2 ng/mL) and TIMP-1(1 578±93 ng/mL) significantly exceeded normal values(18.3±1.6 ng/mL and 1 102±67 ng/mL respectively). Lamivudine treatment resulted in a significant decrease of TGF-β1 and TIMP-1 during treatment with an increase after 24 wk of treatment. Pretreatment MMP-1 levels (6.7±0.7 ng/mL) were significantly lower than normal values (11.9±0.9 ng/mL) and increased during treatment and follow-up. A significant correlation was noted between TGF-β1 or TIMP-1 and aminotransferases as well as fibrosis scored in liver biopsy specimens. There were no statistically significant differences of TGF-β1, TIMP-1 and MMP-1 between four groups at baseline, 24 and 48 wk of treatment. TGF-β1 and TIMP-1 levels increased significantly in non-responders and normalized in responders at wk 72. MMP-1 also normalized in responders and decreased to values significantly lower than normal in non-responders.CONCLUSION: These findings support the role of TGF-β1,TIMP-1 and MMP-1 in the pathogenesis of chronic hepatitis B.Because of their association with hepatic injury and antiviral treatment efficacy, determination of these peptides may be useful in disease management.	Robert Flisiak Haza Al-Kadasi Jerzy Jaroszewicz Danuta Prokopowicz Iwona Flisiak	2004	World Journal of Gastroenterology2004，10，18：	7
2	Spin reorientation transitions in ReF14 BHx compounds 显示文摘	Kuzmin M D Garcia L M Haza I	1995	Journal of Magnetism and Magnetic Materials1995，146，3：	1
3	Myricetin, quercetin, ( + )-eateehin and (-)-epicatechin protect against N-nitrosamines-induced DNA damage in human hepatoma cells显示文摘	Delgado M E Haza A I Garcia A	2009	Toxicol In Vitro2009，21，：	1
4	Location-aware computing comes of age显示文摘	Hazas M Scott J Krumm J	2004	IEEE Computer2004，37，2：	1
5	Protective effects of orga nosulfur compounds towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay 显示文摘	Arranz N Haza A I Garcia A	2007	Food and Chemical Toxicology2007，45，9：	1
6	Implementa- tion of a pedestrian tracker using foot -- mounted inertial sensors 显示文摘	Fischer carl Talkad Sukumar Poorna Hazas Mike	2013	Pervasive Computing IEEE2013，12，2：	1
7	Effects of (+)-catechin and (-)-epicatechin on heterocyclic amines-induced oxidative DNA damage显示文摘	Haza AI Morales P	2011	J Appl Toxicol2011，31，：	1
8	Experimental studies of the flow-front and drag forces exerted by sub-aqueous mudflow on in- clined base 显示文摘	Haza Z F Harahap I S H Dakssa L M	2013	Nat Hazards2013，3，：	1
9	Location-aware computing comes of age显示文摘	Hazas M Scott J Krumm J	2004	Computer2004，37，2：	1
10	Protective effects of organosulfur compounds towards N - nitrosamine - induced DNA damage in the single - cell gel electrophoresis (SCGE)/HepG2 assay 显示文摘	Arranz N Haza A I Garcia A	2007	Food and Chemical Toxicology2007，45，9：	1
11	Antiproliferative effect of towlactic acid bacteria strains of human origin on the growth of a my- eloma cell line显示文摘	ZABALA A MARTIN M R HAZA A I	2001	Lett Appl Microbiol2001，32，4：	1
12	Conditionassessment of concrete structures using a new analysismethod: ground-penetrating radar computer-assisted visualinterpretation显示文摘	TARUSSOV A VANDRY M HAZA A D L	2013	Construction and Building Materials2013，38，：	1
13	Location-aware computing comes of age显示文摘	Hazas M Scott J Krumm J	2004	IEEE Computer2004，37，2：	1
14	Tutorial : Implementation of a pedestrian tracker using foot-mounted inertial sensors 显示文摘	Fischer C Talkad Sukumar P Hazas M	2013	IEEE Pervasive Computing2013，12，2：	1
15	Look back beforeleaping forward: four decades of domestic energyinquiry显示文摘	HAZAS M FRIDAY A SCOTT J	2011	IEEE Pervasive Computing2011，10，1：	1
16	Broadband ultxasonic location system for improved indoor positioning显示文摘	Hazas M Hopper A	2006	IEEE Transactions on Mobile Computing2006，5，5：	1
17	Anti-pmfiferative effect oflactic acid bacteria strains of human origill on the growth of amyeloma cell line显示文摘	gabala A Martin MR Haza AI	2002	Lett Appi Micmbiol2002，32，4：	1
18	Broadband ultrasonic location systems for improved indoor positioning 显示文摘	HAZAS M HOPPER A	2006	IEEE Trans- actions on Mobile Computing2006，5，5：	1
19	Research Ap- proaches in Examining M-Government Services: An In- vestigation显示文摘	NOOR S A AZIZAH A R HAZA N A	2014	International Journal of Computer Sei-ence and Mobile Computing2014，，11：	1
20	Effects of ( + )-catechin and ( - )- epicatechin on heterocyclic amines-induced oxidative DNA damage显示文摘	Haza A I Morales P	2011	J Appl Toxicol2011，31，：	1

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