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| 1 | Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer显示文摘The successes achieved by chimeric antigen receptor-modified T(CAR-T) cells in hematological malignancies raised the possibility of their use in non-small lung cancer(NSCLC). In this phase I clinical study(NCT01869166), patients with epidermal growth factor receptor(EGFR)-positive(>50% expression), relapsed/refractory NSCLC received escalating doses of EGFR-targeted CAR-T cell infusions. The EGFR-targeted CAR-T cells were generated from peripheral blood after a 10 to 13-day in vitro expansion. Serum cytokines in peripheral blood and copy numbers of CAR-EGFR transgene in peripheral blood and in tissue biopsy were monitored periodically. Clinical responses were evaluated with RECIST1.1 and immune-related response criteria, and adverse events were graded with CTCAE 4.0. The EGFR-targeted CAR-T cell infusions were well-tolerated without severe toxicity. Of 11 evaluable patients, two patients obtained partial response and five had stable disease for two to eight months. The median dose of transfused CAR+ T cells was 0.97×10~7 cells kg^(-1)(interquartile range(IQR), 0.45 to 1.09×10~7 cells kg^(-1)). Pathological eradication of EGFR positive tumor cells after EGFR-targeted CAR-T cell treatment can be observed in tumor biopsies, along with the CAR-EGFR gene detected in tumor-infiltrating T cells in all four biopsied patients. The EGFR-targeted CAR-T cell therapy is safe and feasible for EGFR-positive advanced relapsed/refractory NSCLC. | Kaichao Feng Yelei Guo Hanren Dai Yao Wang Xiang Li Hejin Jia Weidong Han | 2016 | Science China(Life Sciences)2016，59，5： | 62 |
| 2 | Removing local irregularities of triangular meshes with highlight line models显示文摘The highlight line model is a powerful tool in assessing the quality of a surface. It increases the ffexibility of an interactive design environment. In this paper, a method to generate a highlight line model on an arbitrary triangular mesh is presented. Based on the highlight line model, a technique to remove local shape irregularities of a triangular mesh is then presented. The shape modification is done by solving a minimization problem and performing an iterative procedure. The new technique improves not only the shape quality of the mesh surface, but also the shape of the highlight line model. It provides an intuitive and yet suitable method for locally optimizing the shape of a triangular mesh. | YONG JunHai DENG BaiLin CHENG FuHua WANG Bin WU Kun GU HeJin | 2009 | Science in China(Series F)2009，52，3： | 5 |
| 3 | X-ray Diffraction of Dust Particles in Spring Beijing显示文摘X 光检查 diffractometry 被利用学习在 3 月 18 日在北京城市里在二灰尘暴风雨期间取样的 inhalable 粒子(PM10 ) 和 2008 年 5 月 21 日的矿物学的特征。第一次,我们证实那稳定地在那里存在在空气的铵氯化物当温度是低的时。全部的硫酸盐粒子被相对湿度影响。硫酸盐的种类和集中首先减少了然后回来在每灰尘暴风雨底成长了。Koninckite,一种磷酸盐矿物质以前从来没作为微粒喷雾器报导,被识别。同时,我们的结果证明灰尘矿物质上的化学修正发生在长期的交通期间。在灰尘暴风雨的时期期间收集的 PM10 样品被象石英, illite/ 绿土, illite,绿泥石,长石和方解石那样的外壳的矿物质统治,并且在时间的正常时期比那在集中是尤其是更高的。在每灰尘改变的全部的硫酸盐,方解石和长石的数量下暴雨。它向后从 24 小时的 isentropic 被导出在春天 2008 的二个灰尘事件在不同来源发源的轨道。 | ZHENG Nan WANG Hejin XU Tingjing LI Ting | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 5 |
| 4 | Comprehensively-modified polymer electrolyte membranes with multifunctional PMIA for highly-stable all-solid-state lithium-ion batteries显示文摘Polyethylene oxide(PEO)-based electrolytes have obvious merits such as strong ability to dissolve salts(e.g.,LiTFSI)and high flexibility,but their applications in solid-state batteries is hindered by the low ion conductance and poor mechanical and thermal properties.Herein,poly(m-phenylene isophthalamide)(PMIA)is employed as a multifunctional additive to improve the overall properties of the PEO-based electrolytes.The hydrogen-bond interactions between PMIA and PEO/TFSI-can effectively prevent the PEO crystallization and meanwhile facilitate the LiTFSI dissociation,and thus greatly improve the ionic conductivity(two times that of the pristine electrolyte at room temperature).With the incorporation of the high-strength PMIA with tough amide-benzene backbones,the PMIA/PEO-LiTFSI composite polymer electrolyte(CPE)membranes also show much higher mechanical strength(2.96 MPa),thermostability(4190℃)and interfacial stability against Li dendrites(468 h at 0.10 mA cm-2)than the pristine electrolyte(0.32 MPa,364℃and short circuit after 246 h).Furthermore,the CPE-based LiFePO4/Li cells exhibit superior cycling stability(137 mAh g^-1 with 93%retention after 100 cycles at 0.5 C)and rate performance(123 mAh g^-1 at 1.0 C).This work provides a novel and effective CPE structure design strategy to achieve comprehensively-upgraded electrolytes for promising solid-state battery applications. | Lehao Liu Jinshan Mo Jingru Li Jinxin Liu Hejin Yan Jing Lyu Bing Jiang Lihua Chu Meicheng Li | 2020 | Journal of Energy Chemistry2020，29，9： | 3 |
| 5 | Water boosted CO_(2)/C_(2)H_(2)separation in L-arginine functionalized metal–organic framework显示文摘The separation of CO_(2)/C_(2)H_(2)mixture by CO_(2)-selective sorbents is an energy-efficient C_(2)H_(2)purification technique,but is strategically challenging due to their similar molecular size and physicochemical properties.Meanwhile,water is inevitable in CO_(2)/C_(2)H_(2)mixture and it is usually a significant barrier because of its competitive adsorption with CO_(2).To address this challenge,herein,we report the first example of metal–organic framework(MOF)that exhibits water-boosted CO_(2)adsorption and CO_(2)/C_(2)H_(2)separation by anchoring L-arginine(ARG)on the Zr6 cluster of MOF-808.The CO_(2)affinity and capacity in the resulting MOF-808-ARG are markedly facilitated by the presence of water,while the C_(2)H_(2)adsorption is significantly suppressed.Specifically,CO_(2)adsorption capacities in adsorption isotherm and breakthrough measurement are increased to 143%and 184%,respectively.In addition,the wet MOF-808-ARG exhibits the record CO_(2)/C_(2)H_(2)selectivity of 1,180 under zero coverage.Breakthrough experiments reveal that CO_(2)/C_(2)H_(2)mixture can be completely separated and the result of mass spectrometry indicates that the C_(2)H_(2)purity in the outlet is up to 99.9%.In situ infrared(IR)results and density functional theory(DFT)calculations reveal the water-promoted CO_(2)adsorption mechanism that the formation of bicarbonate products in the presence of water is thermodynamically and kinetically more favorable than that without water.Moreover,MOF-808-ARG also possesses excellent water stability and excellent regeneration of CO_(2)adsorption.This work provides a new paradigm by transforming the negative effects of water into positive ones for CO_(2)/C_(2)H_(2)separation. | Hejin Zhu Wenjuan Xue Hongliang Huang Lvyun Chen Haoyu Liu Chongli Zhong | 2023 | Nano Research2023，16，5： | 2 |
| 6 | B-spline surface fitting to mesh vertices显示文摘B CAD B B,,, | Yang LU Junhai YONG Kanle SHI Hejin GU Ping ZHENG Jean-Claude PAUL | 2017 | Science China(Information Sciences)2017，60，7： | 2 |
| 7 | A new kind of resin-based wet friction material:Non-woven fabrics with isotropic fiber networks as preforms显示文摘As an alternative to short fibers,non-woven fabrics(NWFs)were made using different types of long fibers to optimize the performance of paper-based friction materials and their technology.In this investigation,the fillers and resin were impregnated into these NWFs to prepare three kinds of wet friction material.The tribological,mechanical,and thermal properties of the new wet friction material were studied.The results indicate that the dynamic friction coefficient of the new friction material is approximately 0.12 and the static friction coefficient is approximately 0.15;the better wear rate is 0.81334×10^(-14)m^(3)·(N·m)^(-1).In addition,the temperature for 10%mass loss yielded 100°C enhancement and the tensile strength was improved by 200%,compared to previously reported values.Most importantly,the advantages include a simple preparation flow,low cost,and resource conservation.This is a promising approach for the future development of paper-based friction materials. | Yewei FU Le ZHOU Tao YIN Zhongyao LUO Hejin LI Lehua QI | 2021 | Friction2021，9，1： | 2 |
| 8 | A NOVEL SVM ENSEMBLE APPROACH USING CLUSTERING ANALYSIS显示文摘A novel Support Vector Machine(SVM) ensemble approach using clustering analysis is proposed. Firstly,the positive and negative training examples are clustered through subtractive clus-tering algorithm respectively. Then some representative examples are chosen from each of them to construct SVM components. At last,the outputs of the individual classifiers are fused through ma-jority voting method to obtain the final decision. Comparisons of performance between the proposed method and other popular ensemble approaches,such as Bagging,Adaboost and k.-fold cross valida-tion,are carried out on synthetic and UCI datasets. The experimental results show that our method has higher classification accuracy since the example distribution information is considered during en-semble through clustering analysis. It further indicates that our method needs a much smaller size of training subsets than Bagging and Adaboost to obtain satisfactory classification accuracy. | Yuan Hejin Zhang Yanning Yang Fuzeng Zhou Tao Du Zhenhua | 2008 | Journal of Electronics(China)2008，25，2： | 2 |
| 9 | Positioning analysis of oversea golf tour destination Korean golf tourist显示文摘 | Samuel Seongseop Kim Hejin Chun James | 2005 | Tourism Management2005，26，： | 1 |
| 10 | A human action recognition algo- rithm based on semi-supervised kmeans clustering显示文摘 | HEJIN YUAN CUIRU WANG | 2014 | Transactions on Edutainment2014，，6： | 1 |
| 11 | Immcenhistochemical staining forclaudin-1 can help distinguish meningiomas from histologic minics显示文摘 | Hejin P Habn MD Elizabeth A | 2006 | Am J Clin Pathol2006，125，： | 1 |
| 12 | Paradoxically Increased FOXP3+ T Cells in IBD Do Not Preferentially Express the Isoform of FOXP3 Lacking Exon 2显示文摘 | James D. Lord Karine Valliant-Saunders Hejin Hahn Richard C. Thirlby Steven F. Ziegler | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 13 | 显示文摘 | WANGYuan Yuan(王园园) ZHAOChang-Wei(赵长伟) HEJin Song(何劲松) etal | 2012 | 无机化学学报2012，28，2： | 1 |
| 14 | Impairment of Microtubule -dependent Trafficking by overExpression of α-synuclein显示文摘 | Farnaz Khoshaghideh Lee Stephen | 2006 | European Journal of Neuroscience2006，24，： | 1 |
| 15 | Ab Initio Calculation of Room Temperature Ionic Liquid 1-Ethyl-3-Methyl-Imidazolium Chlorocuprate (Ⅰ)显示文摘Hartree-Fock 被采用了调查 EMIM (+)(1-ethyl-3-methyl-imidazolium (+)) 的电子结构, CuCl (?) 2, Cu2Cl (?) 3, CuCl2 (?) , EMIM (+)-CuCl(?)2, EMIM (+)-Cu2Cl(?)3, 和 EMIM (+)-CuCl(2?)3 配对。 EMIM (+)的完整的优化和频率分析, CuCl (?) 2 , Cu2Cl (?) 3 , CuCl ( 2 ?) 3 ,八起始的 EMIM (+)-CuCl(?)2,六 EMIM (+)-Cu2Cl(?)3,和四 EMIM (+) -CuCl(2?)3 几何学用在 6-31+G 软包裹的 Gaussian-94 被执行了(氘的符号, p )为氢,碳,氮,氯原子和 Hay-Wadt 的基础集合水平为铜的有效核心潜力原子。EMIM (+)-CuCl(?)2, EMIM (+)-Cu2Cl(?)3, EMIM (+)-CuCl(2?)3, 单身者 EMIM (+) 的最低精力的电子结构, CuCl (?) 2, Cu2Cl (?) 3,并且 CuCl (2 ) 3 (?) 比较地被学习了。计算结果证明最低精力的 EMIM (+)-CuCl(?)3 对 conformer 是到 17 号元素氯的化学符号的五戒指平行 ? aCu ? 有 3.2 的 aCl 吗?距离,最低精力的 EMIM (+)-CuCl(2?)3 对 conformer 是到 CuCl (2 ) 的五戒指平行有 3.4 的 3 (?) 飞机?距离,和最低精力的优化 EMIM (+)-Cu2Cl(?)3 对 conformer 是对 17 号元素氯的化学符号垂直的五枚戒指 ? aCu ? aCl ? aCu ? 有 3.0 的 aCl 飞机吗?在终端 17 号元素氯的化学符号原子和 EMIM (+) 的 5 戒指之间的距离。在阳离子和阴离子之间的结合被 6 号元素碳的化学符号引起 ? 啊 ?- 被费用帮助增强的 17 号元素氯的化学符号氢键。频率分析建议因为没有想象的频率出现,所有静止的点是最小的。分配频率与试验性的报告一致。因为 EMIM (+) 和阳离子和阴离子的费用分散的笨重不对称现象,相互作用的低精力导致离子的液体, EMIM (+)-CuCl(?)2, EMIM (+)-Cu2Cl(?)3, 和 EMIM (+)-CuCl(2?)3 的低熔点。EMIM (+)-CuCl(?)2, EMIM (+)-Cu2Cl(?)3, 和 EMIM (+)-CuCl(2?)3 的相互作用精力分别地是 309.0 kJ/mol, 316.8 kJ/mol,和 320.2 kJ/mol。经由在阳离子和阴离子之间的距离的相互作用精力的关系被单个点精力扫描也调查。给词调音:离子的液体;Hartree-Fock;1-ethyl-3-methyl-imidazolium;chlorocuprate (I) | Renqing Lue Hejin Tangbo Zuogang Cao | 2007 | Journal of Natural Gas Chemistry2007，16，1： | 1 |
| 16 | Positioning analysis of overseas golf tour destinations by Korean golf tourists显示文摘 | Samuel Seongseop Kim Hejin Chun James F | 2005 | Tourism Management2005，26，： | 1 |
| 17 | Long dis- tance laser ultrasonic propagation imaging system for dam- age visualization显示文摘 | Lee Jungryul Shin Hejin Chen Cianghia | 2011 | Optics and Laser Technology2011，49，12： | 1 |
| 18 | Germination Characteristics and Seedling Emer-gence of Switchgrass with Different Agricultural Practices under Arid Conditions in China 显示文摘 | Fan Jing-Wei Du Yan-Lei Tumer Neil C LiFeng-Min HeJin | 2012 | Crop Science2012，52，5： | 1 |
| 19 | Application of trendrelational grade to fuzzy clustering显示文摘 | Xiong Hejin Chen Mainyun Qu Tan | 1996 | Advance of System Science and Applications1996，，6： | 1 |
| 20 | Efficiency and side effects of anti-CD38 CAR T cells in an adult patient with relapsed B-ALL after failure of bi-specific CD19/CD22 CAR T cell treatment显示文摘(CAR)T cells and immune checkpoint blockade therapies has shown remarkable outcomes in the field of cancer treatment.1,2 In particular,great success has been achieved in B cell acute lymphocytic leukemia(B-ALL)treated with anti-CD19 CAR T cells.2 However,the loss,mutation,and reduced expression of CD19 are crucial causes for the failure of CAR T cell treatment in leukemia patients.3,4 CD38,a 45-kDa type II glycoprotein,is detectable in BALL,and several studies have indicated the efficacy and safety of CD38 monoclonal antibodies in clinical applications,suggesting that CD38 represents a suitable therapeutic target for the treatment of B-ALL.5,6 In addition,we developed a CAR against CD38,and our preclinical study indicated that anti-CD38 CAR T(CAR T-38)cells could specifically lyse CD38-positive tumor cells.7 Herein,we present the anti-leukemia ability of CAR T-38 cells in an adult relapsed B-ALL patient after failure of bi-specific CD19/CD22 CAR T cell treatment,and this administration of CAR T-38 cells was accompanied by the occurrence of target-mediated toxicities and severe and uncontrollable cytokine release syndrome(CRS). | Yelei Guo Kaichao Feng Chuan Tong Hejin Jia Yang Liu Yao Wang Dongdong Ti Qingming Yang Zhiqiang Wu Weidong Han | 2020 | Cellular & Molecular Immunology2020，17，4： | 1 |
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