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| 1 | 抗生素使用的时间长短和使用时的生命阶段与全因/特定原因死亡风险的关系:一项前瞻性队列研究显示文摘过度使用抗生素一直是一个重要的临床问题,抗生素使用与肠道微生物菌群的改变有关,肠道菌群的改变与各种慢性疾病如心血管病和癌症的风险有关。此外,抗生素使用的时间可能是过早死亡的一个危险因素。研究者调查了成年期间使用抗生素的生命阶段和使用持续时间与全因和特定原因死亡风险的关系。该项前瞻性队列研究包括来自护士健康研究、均未患有心血管病或癌症的37516名年龄≥60岁的女性,收集其中年(40~59岁)和老年(≥60岁)使用抗生素的时间(无,<15d,15d至<2个月,或≥2个月)。研究者根据抗生素的使用时间估计10年内全因死亡率和心血管病或癌症的死亡风险比(HR)。在355918人年的随访中,研究者记录了所有原因导致的4536例死亡(包括728例心血管病死亡和1206例癌症死亡) | 刘青(译) 叶鹏(摘 审校) Heianza Y Ma W Li X Cao Y Chan A Rimm EB Hu FB Rexrode K Manson JE Qi L | 2020 | 中华高血压杂志2020，28，2： | 2 |
| 2 | Low serum potassium levels and risk of type 2 diabetes: the Toranoraon Hospital Health Management Center Study 1 ( TOPICS 1 ) 显示文摘 | Heianza Y Hara S Arase Y | 2011 | Diabetologia2011，54，4： | 1 |
| 3 | Screening for pre-diabetes to predict future diabetes using various cut-off points for HbA(1 c) and impaired fasting glueose: the Toranomon Hospital Health Management Center Study 4 (TOPICS 4)显示文摘 | Heianza Y Arase Y Fujihara K | 2012 | Diabet Med2012，29，9： | 1 |
| 4 | Skipping breakfast and prevalence of overweight and obesity in Asian and Pacific regions: A meta-analysis显示文摘 | Chika Horikawa Satoru Kodama Yoko Yachi Yoriko Heianza Reiko Hirasawa Yoko Ibe Kazumi Saito Hitoshi Shimano Nobuhiro Yamada Hirohito Sone | 2011 | Preventive Medicine2011，，4： | 1 |
| 5 | Role of sleep duration as a risk factor for type 2 diabetes among adults of different ages in Japan: the Niigata wellness study 显示文摘 | HEIANZA Y KATO K FUJIHARA K | 2014 | Diabet Med2014，31，11： | 1 |
| 6 | Development of a screening score for undiagnosed diabetes and its application in estimating absolute risk of future type 2 diabetes in Japan:Toranomon Hospital Health Management Center Study 10显示文摘 | Heianza Y Arase Y Saito K | 2013 | J Clin Endocrinol Metab2013，98，： | 1 |
| 7 | Role of alcohol drinking pat- tern in type 2 diabetes in Japanese men:the Toranomon HospitalHealth Management Center Study 1 l显示文摘 | Heianza Y Arase Y Saito K | 2013 | Am J Clin Nutr2013，97，3： | 1 |
| 8 | Association be- tween physical activity and risk of all-cause mortality and cardi- ovascular disease in patients with diabetes:a meta-analysis显示文摘 | KODAMA S TANAKA S HEIANZA Y etal | 2013 | Diabetes Care2013，36，2： | 1 |
| 9 | Low serum potassium levels and risk of type 2 diabetes:the Toranomon Hospital Health Management Center Study 1 (TOPICS 1)显示文摘 | Heianza Y Hara S Arase Y | | 0，，： | 1 |
| 10 | Assessment of kid- ney dysfunction with cystatin C and creatinine - based esti- mated glomerular filtration rate and predicting type 2 diabe- tes: Toranomon Hospital Health Management Center Study 21显示文摘 | HEIANZA Y HARA S SAITO K | 2016 | Diabetes ResClin Pract2016，113，： | 1 |
| 11 | Role of alcohol drinking pattern in type 2 diabetes in Japanese men:the toranomon hospital health management center study 11显示文摘 | Heianza Y Arase Y Saito K | 2013 | Am J Clin Nutr2013，97，3： | 1 |
| 12 | Screening for pre-diabetes to predict future diabetes using various cut-off points for HbA(1c) and impaired fasting glucose:the Toranomon Hospital Health Management Center Study 4(TOPICS 4)显示文摘 | Heianza Y Arase Y Fujihara K | | 0，，09： | 1 |
| 13 | Low lung function and risk of type 2 diabetes in Japanese men:the Toranomon Hospital Health Management Center Study 9(TOPICS 9)显示文摘 | Heianza Y Arase Y Tsuji H | 2012 | Mayo Clin Proc2012，87，9： | 1 |
| 14 | Association between physical activity and risk of all-cause mortality and cardiovascular disease in patients with diabe- tes: a rneta-analysis显示文摘 | Kodama S Tanaka S Heianza Y | 2013 | Diabetes Care2013，36，： | 1 |
| 15 | HbA 1c 5·7–6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study显示文摘 | Yoriko Heianza Shigeko Hara Yasuji Arase Kazumi Saito Kazuya Fujiwara Hiroshi Tsuji Satoru Kodama Shiun Dong Hsieh Yasumichi Mori Hitoshi Shimano Nobuhiro Yamada Kinori Kosaka Hirohito Sone | 2011 | The Lancet2011，，9786： | 1 |
| 16 | Association between physical activity and risk of all-cause mortality and cardiovascular disease in patients with diabetes : a meta-analysis 显示文摘 | Kodama S Tanaka S Heianza Y | 2013 | Diabetes Care2013，36，2： | 1 |
| 17 | Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized Controlled Trials Worldwide显示文摘Objective.The strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).Methods.From October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 RCTs.These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults.Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies.Results.In the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting glucose.Compared with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,p<0:05;z=2:20,p=0:028)per one copy of the TCF7L2 T risk allele.Furthermore,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist circumference.However,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk allele.Conclusions.Our findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults. | Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup Dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner Joan Sabaté Dolores Corella J.Alfredo Martinez Lu Qi | 2021 | Health Data Science2021，，1： | 0 |
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