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208篇 您的检索式:作者名="Heijde M"
    题名 作者 年代 出处 被引量
1A Short Amino-Terminal Part of Arabidopsis Phytochrome A Induces Constitutive Photomorphogenic Response显示文摘Phytochrome A (phyA ) 是在 Arabidopsis thaliana 察觉到的 far-red 光的主导的光敏电阻器。phyA 在发信号的变白的幼苗,和导致光的 phyA 的细胞质在高水平积累被一个复杂规章的网络调停。这包括光 -- 并且进在 vivo 的原子核的本国的 phyA 的 FHY1/FHL 蛋白质依赖者 translocation。phyA (PHYA406 ) 的短 N 终端碎片对 phenocopy 足够,这也被显示出在 vitro 的这个高度调整的细胞的过程。为了测试这 N 终端的生物活动,在 planta phyA 碎裂,我们生产了表示 PHYA406YFP 的转基因的 phyA-201 植物(黄荧光灯蛋白质) DD, PHYA406YFPDDNLS (原子本地化信号) ,和 PHYA406YFPDDNES (原子出口信号) 熔化蛋白质。这里,我们报导 PHYA406YFPDD 被进口进原子核,而 PHYA406YFPDDNLS 和 PHYA406YFPDDNES 显示期望的组成的本地化模式,这进程部分是轻依赖者的。我们的结果证明这些截断的 phyA 蛋白质是轻马厩的,当局部性时,他们在他们的原子核,和两个都不触发组成的象 photomorphogenic 一样回答导致合适的 phyA 发信号。我们证明在 vitro 并且在 vivo PHYA406, Pfr 和 Pr 绑 COP1, photomorphogenesis 的一个一般抑压者,并且在原子身体与它共同本地化。因此,我们断定在 planta,截断的 PHYA406 蛋白质以一种光无关的方式在原子核使 COP1 失去活性。Andra's Viczia'n E'va Ada'm Iris Wolf Ja'nos Bindics Stefan Kircher Marc Heijde Roman Ulm Eberhard Scha'fer Ferenc Nagy 2012Molecular Plant2012,5,3:2
2Efficacy and safety of adallmumab in patients with non-radiographic axial spondyloarthritis: results of a randomised placebo-controlled trial (ABILITY-1) 显示文摘SIEPER J VAN DER HEIJDE D DOUGADOS M 2012Ann Rheum Dis2012,,:1
3TheAssessment of SpondyloArthritis International Societyclassification criteria for peripheral spondyloarthritis and forspondyloarthritis in general显示文摘Rudwaleit M van der Heijde D LandewéR 2011Ann Rheum Dis2011,70,1:1
4Infliximab and methotrexate in the treatment of rheumatoid arthritis显示文摘Lipsky P E Van der Heijde D M St clair E W 2000N Eng J Med2000,343,:1
5How to diagnose axial spondyloarthritis early显示文摘Rudwaleit M van der Heijde D Khan MA 2004Ann Rheum Dis2004,63,5:1
6UV-B photoreeeptor-mediated sig- nalling in plants显示文摘Heijde M Ulm R 2012Trends in Plant Science2012,17,4:1
7Efficacy and safety of adalimumab in patients with ankylosing spondylitis: Results of a multicenter, randomized, double-blind, placebo-controlled trial显示文摘van der Heijde D Kivitz A Schiff M H 2006Arthritis Rheum2006,54,7:1
8Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen 1997The Lancet1997,,9074:1
9Infliximab and methotrexate in the treatment of rheumatoid arthritis显示文摘LIPSKY P E van der HEIJDE D M F M ST-CLAIR E W 2000N Engl J Med2000,343,22:1
10Baseline factors that influence ASAS20response in patients with ankylosing spon-dylitis treated with a recombinant human tumor necosis factor-Fc fusion protein显示文摘Davis JC Van der Heijde DM Dougados M 2005J Rheumatol2005,32,:1
11Reversion of the Arabidopsis UV-B photoreceptor UVR8 to the homodimeric ground state显示文摘HEIJDE M ULM R 2013Proceedings of theNahona/Acatm y o/SWences USA2013,110,3:1
12Outcome variables for oste- oarthritis clinical trims : The OMERACT - OARSI set of responder crite- ria 显示文摘Pham T Van Der Heijde D Lassere M 2003J Rheumato12003,30,7:1
13How to diag-nose axial spondyloarthritis early显示文摘 van der Heijde D Khan MA 2004Ann Rheum Dis2004,63,5:1
14Baseline fac-tors that influence ASAS 20 response in patients with ankylosing spondylitis treated with etanercept 显示文摘Davis JC Jr van der Heijde DM Dougados M 2005J Rheumatol2005,32,9:1
15Joint erosions and patients with early rheumatoid arthritis显示文摘VANDER HEIJDE D M F M 1995Br J Rheumato1995,34,:1
16Are syndesmophytes most prevalent in the lumbar or in the cer- vical spine in patients with ankylosing spondylitis and do they develop in a specific direction显示文摘van Tubergen A van der Heijde D Dougados M 2012Rheumatology(Oxford)2012,51,8:1
17Negative feedback regulation of UV-B-induced photomorphogenesis and stress acclimationin Arabidopsis显示文摘GRUBER H?HEIJDE M HELLER al 2010Proceedings of the National Academy of Sciences USA2010,107,20:1
18The shape of the aging human lens: curvature, equivalent refractive index and the lens paradox显示文摘Dubbelman M Van der Heijde G L 2001Vision Res2001,41,14:1
19Development of a multi-dimensional health assessment questionnaire (MDHAQ) for the infrastructure of stand7 ard clinical care显示文摘van der Heijde DM van 't Hof M van Riel PL 2005Clin Exp Rheumatol2005,32,10:1
20The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part Ⅱ) : validation and final selection 显示文摘RUDWALEIT M VAN DER HEIJDE D LANDEWE 2009Ann Rheum Dis2009,68,6:1
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