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| 1 | Parameters affecting different acoustic radiation force impulse applications in the diagnosis of fibrotic liver changes显示文摘AIM: To analyze the virtual touch tissue quantification(VTTQ) and virtual touch imaging quantification(VTIQ) techniques, and identify possible factors that may influence VTTQ and VTIQ measurements.METHODS: One hundred and eighty-six(104 women/82 men) of 323 subjects met the inclusion criteria(age > 18 years, no history of chronic or gastrointestinal disease, body-mass index(BMI) < 30 kg/m2, a fasting period of at least three hours, no history of hepatotoxic pharmaceuticals, alcohol consumption < 24 g/d in men and < 12 g/d in women, and normal findings upon ultrasound examination of the abdomen). Measurements were taken at depths of 50 mm with VTTQ, 15 mm and 25 mm with VTIQ in the right hepatic lobe, and at 15 mm with only VTIQ in the left hepatic lobe. The examiner acquired six measurements per position, thereby giving 24 measurements in total.RESULTS: The 95% confidence intervals of mean were1.23-1.29 m/s for VTTQ and 1.29-1.37 m/s, 1.17-1.23 m/s, and 1.48-1.57 m/s for VTIQ in a depth of 15 mm and 25 mm in the right hepatic lobe and 15 mm in the left hepatic lobe. Only superficial measurements in the right hepatic lobe with the VTIQ method exhibited an effect of age on shear wave velocity. Measurements acquired using the 6C1 probe with the VTTQ method showed no dependence on BMI. By comparison, BMI influenced measurements taken with the VTIQ method using the 9L4 probe in the superficial and deep areas of the right hepatic lobe, as well as in the left hepatic lobe(P = 0.0160, P = 0.0019, P = 0.0173, respectively). Gender influenced measurements at depths of 50 mm with VTTQ and 25 mm with VTIQ in the right hepatic lobe(P = 0.0001, P = 0.0269). Significant differences were found between measurements with the 6C1(VTTQ) and 9L4 probes(VTIQ)(P = 0.0067), between superficial and deep measurements(P < 0.0001), and between the right and left lobes of the liver(P < 0.0001). CONCLUSION: Measurements in the right lobe and deep regions are preferable. Gender differences must be considered. BMI must be considered when assessing VTIQ technology. | Sabrina Galgenmueller Heike Jaeger Wolfgang Kratzer Stefan A Schmidt Suemeyra Oeztuerk Mark M Haenle Richard A Mason Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，27： | 5 |
| 2 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 3 | 显示文摘 | TATIANA A S HEIKE M SERGIY A P | 2001 | J Chromatogr A2001，907，： | 1 |
| 4 | Chemo- therapy of colorectal cancer显示文摘 | Heike M Meyer zum Buschenfelde KH Knuth A | 1989 | Z Gastroenterol1989，27，9： | 1 |
| 5 | Stress protein/peptide complexes derived from autologous tumor tissue as tumor vaccines显示文摘 | Heike M Weinmann A Bethke K | 1999 | B iochem Phannacol1999，58，9： | 1 |
| 6 | Molecularly imprinted polymermembranes for substance-selecttive solid-phase extraction from water by sufance photo-grafting polymerization显示文摘 | SERGEYEVA TATIANA A HEIKE MATUSCHEWSKI PILETSKY SERGIY A | 2001 | J Chromato graphy A2001，907，： | 1 |
| 7 | Cytokine production and migration of in vitro-expanded NK1.1(-) invariant Valpha14 natural killer T (Valpha14i NKT) cells using alpha-galactosylceramide and IL-2.显示文摘 | lkarashi Y lizuka A Heike Y | | 0，，： | 1 |
| 8 | Segmental heterogeneity of vasa vasorum neovascularization in human coronary atherosclerosis显示文摘 | G(o)ssl M Versari D Heike A | 2010 | J Am Coll Cardiol2010，3，： | 1 |
| 9 | Effects of preoperative videotapes on self- efficacy beliefs and recovery from coronary bypass surgery显示文摘 | Heike I M Mahler James A | 1998 | Annual of Behavior Medicine1998，20，1： | 1 |
| 10 | Molecularly imprinted polymer membranes for substance-selective solid-phase extraction from water by surface photo-grafting polymerization显示文摘 | Tatiana A Sergeyeva Heike Matuschewski Sergiy A Piletsky | 2001 | J Chromatogr A2001，907，： | 1 |
| 11 | On reconciling the interactions between APETALA2, miR172 and AGAMOUS with the ABC model of flower development 显示文摘 | Heike W Erica M Marco T Jeff A L Detlef W | 2010 | Development2010，137，： | 1 |
| 12 | Stress protein/peptide complexes derived from autologous tumor tissue as tumor vaccines 显示文摘 | Heike M Weinmann A Bethke K | 1999 | Biochem Pharmacol1999，58，9： | 1 |
| 13 | Stress protein-peptide complex derived from autologous tumor tissue as tumor vaccines显示文摘 | Heike M Weinmann A Bethke K | | 0，，： | 1 |
| 14 | Stress protein/peptide complexes derived from autologous tumor vaccine显示文摘 | Heike M Weinmann A Bethke K | 1999 | Biochem Pharmacol1999，58，： | 1 |
| 15 | Stress protein-peptide complexes derived from autologous tumor tissue as tumor vaccines显示文摘 | Heike M Weinmann A Bethke K | | 0，，： | 1 |
| 16 | Craniofacial defects of blastogenesis:duplication of pituitary with cleft palate and orophgaryngeal tumors显示文摘 | Slavotinek A Parisi M Heike C | 2005 | Am J Med Genet A2005，135，1： | 1 |
| 17 | Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials 显示文摘 | Heike A Bischoff-Ferrari HA Walter C | 2005 | JAMA2005，293，： | 1 |
| 18 | Enanti- oselective crystallization exploiting the shift of eutectic compositions in solid-liquid phase diagrams 显示文摘 | Tam Le Minh Heike Lorenz Morgenstern A S | 2012 | Chem Eng TechnoI2012，35，6： | 1 |
| 19 | Mechanisms of leptin action and leptin resistance显示文摘 | Martin G Michael A Heike Munzberg | 2008 | Ann Rev Physiol2008，70，3： | 1 |
| 20 | Molecularly imprinted polymer membranes for substance-selective solid-phase extraction from water by surface photo-grafting polymerization显示文摘 | Tatiana A S Heike Matuschewski Sergiy A P etc | 2001 | J Chromat A2001，907，： | 1 |
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