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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 3 | New mechanism of antiarrhythmic drug action显示文摘 | Candido C Heiko S Andrew Lw | 2000 | Circ2000，102，19： | 1 |
| 4 | Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis显示文摘 | Heiko Mahrholdt Anja Wagner Claudia C. Deluigi Eva Kispert Stefan Hager Gabriel Meinhardt Holger Vogelsberg Peter Fritz Juergen Dippon C Thomas Bock Karin Klingel Reinhard Kandolf Udo Sechtem | 2006 | Circulation2006，，15： | 1 |
| 5 | Conservation,diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome显示文摘 | CLAUDIA C E HEIKO S SIEGFRIED B | 2004 | BMC Genomic2004，5，： | 1 |
| 6 | Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis显示文摘 | Heiko Mahrholdt Anja Wagner Claudia C. Deluigi Eva Kispert Stefan Hager Gabriel Meinhardt Holger Vogelsberg Peter Fritz Juergen Dippon C Thomas Bock Karin Klingel Reinhard Kandolf Udo Sechtem | 2006 | Circulation2006，，： | 1 |
| 7 | Improved colloidal stability of bacterial cellulose nanocrystal suspensions for the elaboration of spin-coated cellulose-based model surfaces显示文摘 | Heiko T W Carole C Nicolas D | 2010 | Biomacromolecules2010，11，11： | 1 |
| 8 | Variation and inheritance of erucic acid content in Brassica carinata germplasm collections from Ethiopia显示文摘 | Alemayehu N Becker H C Heiko C | 2001 | Plant Breeding2001，120，： | 1 |
| 9 | Propofol and remifentanil phar macodynamic interaction during orthopedic surgical procedures as measured by effects on bispectral index显示文摘 | Heiko R Michael KB Monju C | 2001 | J Clin Anesth2001，13，： | 1 |
| 10 | A comprehensive characterization of the caspase gene family in insectsfrom the order Lepidoptera显示文摘 | Juliette C Yannick P Heiko V | 2011 | BMC Genomics2011，，： | 1 |
| 11 | The surface tension of aqueous solutions of some atmospheric water-soluble organic compounds 显示文摘 | RUDOLF T HEIKO K C | 2004 | Atmospherie Environment2004，38，36： | 1 |
| 12 | Variability for seed glucosinolates in a germplasm collection of the genus Brassica显示文摘 | Leonardo V Heiko C B | 2000 | Phytochemistry2000，47，： | 1 |
| 13 | Effects of endotoxin on human myocardial contractility involvement of nitric oxide and peroxynitrite 显示文摘 | Markus F Heiko K Bodo C | 1999 | J Am Coll Cardio1999，33，： | 1 |
| 14 | Factors that contribute to genetic varietion for nutrient efficiency of crop plants显示文摘 | Sattelamacher B Walter J Horst Heiko C Becker | 1994 | Z pflanzenernahr Bodenk1994，157，： | 1 |
| 15 | Non-destructive analysis of rapeseed quality by NIRS of small seed samples and single seeds显示文摘 | Nang Hseng Hom Heiko C Becker | 2007 | Euphytica2007，153，： | 1 |
| 16 | Non-destructive analysis of rapeseed quality by NIRS of small seed samples and single seeds 显示文摘 | Nang H H Heiko C B Christiam M | 2007 | Euphtiea2007，153，： | 1 |
| 17 | Oil content in a European × Chinese rapeseed population:QTL with additive and epistatic effects and their genotype - environment interactions 显示文摘 | Zhao J Y Heiko C Becker | 2005 | Crop Science2005，45，： | 1 |
| 18 | Genetic Analysis of Heterosis for Yield and Yield Components in Rapeseed (Brassica napus L.) by Quantitative Trait Locus Mapping显示文摘 | Radoev Mladen Becker Heiko C Ecke Wolfgang | 2008 | Genetics2008，，3： | 1 |
| 19 | Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2) 显示文摘 | Heiko A Janice L B Nadia C D P | 1997 | J Exp Med1997，185，9： | 1 |
| 20 | Synthesis and properties a no- vel electron aeeeptor derived from p-benzoquinone显示文摘 | Heiko B Nathalie L C Jean P G | 1999 | Tetrahed- ron Letters1999，40，26： | 1 |
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