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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors显示文摘AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 immunohistochemistry.In addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial cells.CD31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs. | Patricia Kuiper Lukas JAC Hawinkels Eveline SM de Jonge-Muller Izk Biemond Cornelis BHW Lamers Hein W Verspaget | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 3 | Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer显示文摘Matrix metalloproteinases(MMPs) are implicated in cancer development and progression and are associated with prognosis.Single-nucleotide polymorphisms(SNPs) of MMPs,most frequently located in the promoter region of the genes,have been shown to influence cancer susceptibility and/or progression.SNPs of MMP-1,-2,-3,-7,-8,-9,-12,-13 and-21 and of the tissue inhibitor of metalloproteinases(TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors.The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper. | Alexandra MJ Langers Hein W Verspaget Daniel W Hommes Cornelis FM Sier | 2011 | World Journal of Gastrointestinal Oncology2011，3，6： | 4 |
| 4 | An abattoir survey of tuberculosis in feral buffaloe 显示文摘 | Hein W R Tomasovic A A | 1981 | Australian Veterinary Journal1981，57，12： | 1 |
| 5 | Relationship of casting defects to solidification of malleable base white cast iron 显示文摘 | Leon C Ekpoon U Heine R W | 1981 | AFS Transitions1981，89，： | 1 |
| 6 | Cue reactivity and effects of exposure in abstinent posttreatment drug users显示文摘 | Ingmar HA Hein A Chris W | 1999 | J Subst Abuse Treat1999，16，： | 1 |
| 7 | Methanogenic calcite,13C-depleted bivalve shells,and gas hydrate from a mud volcano offshore southern California显示文摘 | Hein J R Normark W R McIntyre B R | 2006 | Geology2006，34，： | 1 |
| 8 | Optimization of stabilization and carbonization treatment of PAN fibres and structural characterization of the resulting carbon fibres显示文摘 | FITER E FROBS W HEINE M | 1986 | Carbon1986，24，4： | 1 |
| 9 | A stable non- classical metallofullerene family显示文摘 | Stevenson S Fowler P W Heine T | 2000 | Nature2000，408，6811： | 1 |
| 10 | Optimization of stabilization and carbonization treatment of PAN fibers and structural characterization of the resulting carbon fibers显示文摘 | Fitzer E Frohs W Heins M | 1987 | Carbon1987，24，4： | 1 |
| 11 | Prevention of deep-vein thrombosis after total hip and knee replacement:low-molecular-weight heparin in combination with intermittent pneumatic compression显示文摘 | Silbersack Y Taute BM Hein W | 2004 | J Bone Joint Surg(Br)2004，86，： | 1 |
| 12 | Synthesis of some dialkylsubstituted vinylene carbonates and their photosensitized cycloaddition to ethylene 显示文摘 | Fischler H M Heine H G Hartmann W | 1972 | Tetrahedron Lett1972，17，： | 1 |
| 13 | Sampling and quantifying invertebrates form drinking water distribution mains显示文摘 | Hein M van Lieverloo Dick W B Geo L B | 2004 | Water Research2004，38，3： | 1 |
| 14 | The MBOC modulation: the final touch to the Galileo frequency and signal plan显示文摘 | AVILA-RODRIGUEZ J A HEIN G W WALLNER S | 2007 | Inside GNSS2007，，9： | 1 |
| 15 | Precipitation of graphite during the solidification of cast iron显示文摘 | R W Heine | 1966 | Trans A F S1966，74，： | 1 |
| 16 | Soft palate implants:a new option for treating habitual snoring显示文摘 | Kuhnel TS Hein G Hohenhorst W | 2005 | Eur Arch Otorhinolaryngol2005，262，： | 1 |
| 17 | Hafnium isotope stratigraphy of ferromanganese crusts 显示文摘 | Lee D-C Halliday A N Hein J R Burton K W Christensen J N Günther D | 1999 | Science1999，285，5429： | 1 |
| 18 | Cd, Zn, Ni and Cu in the India Ocean 显示文摘 | qPaul M S Hein J W Robin H | 1992 | Deep -Sea Research1992，39，1： | 1 |
| 19 | Fate of 14C-bisphenol A in soils 显示文摘 | Fent G Hein J W Moendel J M | 2003 | Chemosphere2003，51，8： | 1 |
| 20 | Variation in the fine-scale composition of a central Pacific ferromanganese crust: Paleocenographic implications显示文摘 | HEIN J R BOHRSON W A SCHULZ M S | 1992 | Paleoceanography1992，7，： | 1 |
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