|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes. | Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust | 2008 | World Journal of Gastroenterology2008，14，7： | 29 |
| 2 | 海绵动物的演化意义及其生物硅的仿生应用显示文摘海绵动物是地球上最古老、最简单的动物,但对它在生物进化中的定位却经历了一个漫长而复杂的认识过程.作为“活化石”,海绵动物为生物演化研究提供了最好的证据;而对海绵动物研究更令人入胜的是近年来人们发现硅质海绵动物骨针的独特结构和良好光纤特性,从而开辟了利用纳米生物技术进行仿生合成的广泛研究领域.综述了海绵动物的发现及新的分子生物学进化证据,骨针硅蛋白催化合成生物硅的研究进展及仿生合成在纳米生物技术和医学领域的潜在应用. | Werner E G Müller 王晓红 曾令森 Heinz C Schrder | 2007 | 科学通报2007，52，12： | 4 |
| 3 | Phylogenetic position of sponges in early metazoan evolution and bionic applications of siliceous sponge spicules显示文摘Sponges are the oldest and the simplest but not primitive multicellular animals. They represent the earliest evolutionary metazoan phylum still extant. It was a long and painful scientific process to posi-tion the most enigmatic and mysterious metazoan,the Porifera,into their correct phylogenetic place among the eukaryotes in general and multicellular animals in particular. As living fossils,sponges provide the best evidence for the early evolution of Metazoa. More recently,interest has been focused on the bionic applications of sponges' siliceous spicules,after the discovery of their unique structure and high fiber performance. In this review,the emergence of sponges,evolutionary novelties found in sponges,and the phylogenetic position of sponges in early metazoan evolution are highlighted. In ad-dition,the present state of knowledge on silicatein-mediated 'biosilica' formation in marine sponges,including the involvement of other molecules in silica metabolism and their potential application in nanobiotechnology and medicine,is given. | Werner E G MULLER WANG XiaoHong ZENG LingSen Heinz C SCHRODER | 2007 | Chinese Science Bulletin2007，52，22： | 3 |
| 4 | Evaluation of putative seed-specific promoters for Linum usitatissimum显示文摘 | Drexler H H S Scheffler J A Heinz E | 2003 | Molecular Breed- ing2003，11，： | 1 |
| 5 | Fungal bio-transformation of benzo quinoline,benzo quino-line ,and phenanthridine显示文摘 | Sutherland J B Cross E L Heinze T M | 2005 | Appl Microbiol Biotechn-ol2005，67，： | 1 |
| 6 | Brassiea napus cDNAs encoding fatty acyl - CoA synthetase 显示文摘 | Fulda M Heinz E Wolter F P | 1997 | Plant Mol Biol1997，33，： | 1 |
| 7 | Purification of a membrane-boundUDP-glucose: sterol jff-D-glucosyltransferase based on its solubility indiethyl ether显示文摘 | WARNECKE D C HEINZ E | 1994 | Plant Physiology1994，105，4： | 1 |
| 8 | Analytical methods for detection and determination of genetically modified organisms in agricultural crops and plant-derived food products显示文摘 | Gadani F Heinze P | 2002 | Eur Food Res Technol2002，214，： | 1 |
| 9 | Analytical methods for detection and determination of genetically modified organisms in agricultural crops and plant-derived food products显示文摘 | Anldanl E Gadani F Heinze P | 2002 | European Food Research and Technology2002，214，1： | 1 |
| 10 | Analytical methods for detection and determination of genetically modified organisms in agricultural crops and plantderived food products显示文摘 | ANKLAM E GADANI F HEINZE P | 2002 | European Food Research and Technology2002，214，： | 1 |
| 11 | Analytical methods for detection and determination of genetically modified organisms in agricultural crops ang plants- derived food products 显示文摘 | Antdam E Gadani F Heinze P | 2002 | Eur Fctxt Res Technol2002，214，： | 1 |
| 12 | Assessment of high pressure in-duced damage on Lactobacillus rharnnosus GC by flow cytometry显示文摘 | ANANTA E HEINZ V KNORR D | 2004 | Food Microbiology2004，21，5： | 1 |
| 13 | Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques 显示文摘 | Kempe S Heinz P Kokai E | 2009 | Am J Pathol2009，175，1： | 1 |
| 14 | The role of growth hormone/insulin-like growth factors in adipocyte differentiation 显示文摘 | Wabitsch M Hauner H Heinze E | 1995 | Metabolism1995，44，104： | 1 |
| 15 | Dilated Virchow-Robin spaces in eryptococcal meningitis associated with AIDS: CT and MR findings显示文摘 | Wehn S M Heinz E R Burger P C | 1989 | J Comput Assist Tomogr1989，13，5： | 1 |
| 16 | Thermal Phenomenology of Hadrons from 200-A/GeV S+S Collisions显示文摘 | Schnedermann E Sollfrank J Heinz U | 1993 | Phys Rev C1993，48，5： | 1 |
| 17 | On Evolution of Particle Size Distribution Functions of Incipient Soot in Premixed Ethylene-Oxygen-Argon Flames显示文摘 | Abid A D Heinz N Tolmachoff E | | 0，，4： | 1 |
| 18 | Thermal Phenomenology of Hadrons from 200-A/GeV S+S Collisions显示文摘 | Schnedermann E Sollfrank J Ulrich Heinz | 1993 | Phys Rev C48:2462-24751993，48，： | 1 |
| 19 | Specifici- ties and selectivities of glycerol-3-phosphate acyl- transferase and monoacylglycerol-3-phosphate acyl- transIerase from pea and spinach chloroplasts 显示文摘 | Frentzen M Heinz E Mckeon TA | 2003 | European Journal of Biochemistry2003，129，： | 1 |
| 20 | Epstein-Barr Virus-Induced gene-3 is expressed in human atheroma plaques显示文摘 | KEMPE S HEINZ P KOKAI E | 2009 | American Journal of Pathology2009，175，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员