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1篇 您的检索式：作者名="Helen Goodluck"

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		题名	作者	年代	出处	被引量
	1	Role and mechanism of action of leucine-rich repeat kinase 1 in bone显示文摘Leucine-rich repeat kinase 1 (LRRK1) plays a critical role in regulating cytoskeletal organization, osteoclast activity, and bone resorption with little effect on bone formation parameters. Deficiency of Lrrk1 in mice causes a severe osteopetrosis in the metaphysis of the long bones and vertebrae bones, which makes LRRK1 an attractive alternative drug target for the treatment of osteoporosis and other high-turnover bone diseases.This review summarizes recent advances on the functions of the Lrrk1-related family members, Lrrk1deficiency-induced skeletal phenotypes, LRRK1 structure–function, potential biological substrates and interacting proteins, and the mechanisms of LRRK1 action in osteoclasts.	Weirong Xing Helen Goodluck Canjun Zeng Subburaman Mohan	2017	Bone Research2017，5，1：	2

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