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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts显示文摘Glutamine is the most abundant amino acid in milk, and lactation is associated with increased glutamine utilization both for milk synthesis and as a fuel for the enlarged small intestine. A number of recent studies have indicated that lactation is accompanied by a mild catabolic state in which skeletal muscle proteins are degraded to provide amino acids that are used to synthesize additional glutamine. In this study we tested the hypothesis that supplemental L-glutamine or the commercially available glutamine supplement Aminogut (2.5% by weight mixed into daily feed) provided to gilts from 30 days prior to parturition until 21 days post-parturition would prevent a decrease in skeletal muscle glutamine while increasing the glutamine content of the milk. Muscle glutamine content decreased (P < 0.05) in control animals during lactation but this was prevented by supplementation with either L-glutamine or Aminogut. In this study, neither lactation nor supplementation had any effect on plasma glutamine or glutamate content. Free glutamine, and the total glutamine plus glutamate concentrations in milk from the control and the Aminogut group rose (P < 0.05) during the first 7 days of lactation, with milk concentrations in the L-glutamine supplemented group showing a similar trend (P = 0.053). Milk glutamate remained constant between day 7 and 21 of lactation in the control and L-glutamine supplemented groups, but by day 21 of lactation the free glutamine, glutamate, and glutamine plus glutamate concentrations in milk from Aminogut-treated gilts were higher than those of control gilts. Thus dietary glutamine supplementation can alleviate the fall in intramuscular glutamine content during lactation in gilts, and may alleviate some of the catabolic effects of lactation. Furthermore, the increased milk glutamine content in the supplemented gilts may provide optimum nutrition for piglet development. | Helena Emilia CCC Manso Helio C Manso Filho Luiz E de Carvalho Marianne Kutschenko Eduardo T Nogueira Malcolm Watford | 2012 | Journal of Animal Science and Biotechnology2012，3，1： | 3 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | The effect of dietary protein replacement by crystalline amino acid on growth and nitrogen utilization of turbot Scophthalmus mazimus juveniles 显示文摘 | Helena P Aires O T | 2005 | Aquaculture2005，250，75： | 1 |
| 5 | Confirmation of tubal patencyin hysterosalpingo -contrast sonography by transvaginalhydrolaparoscopy 显示文摘 | Katja M Heini H Helena T | 2009 | Acta Obstet Gynecol2009，88，3： | 1 |
| 6 | Vitamins B1 and B2 contents in cultivated mushrooms显示文摘 | REGINA PZF HELENA T G | 2008 | Food Chemistry2008，106，2： | 1 |
| 7 | Lysine requirement and efficiency of lysine utilization in turbot (Scophthalmus maximus) juveniles显示文摘 | HELENA P AIRES O T | 2008 | Aquaculture2008，275，： | 1 |
| 8 | The validity of air and salinehysterosalpingo-contrast sonography in tubal patency inves-tigation before insemination treatment显示文摘 | Katja AH Heini H Helena T | 2007 | Eur J Obstet GynReprad Biol2007，132，1： | 1 |
| 9 | An exploratory spatial da- ta analysis approach to understanding the relationship between deprivation and mortality in Scotland显示文摘 | Sanjeev S Helena T Richard L | 2007 | Social Science & Me- dicine2007，65，： | 1 |
| 10 | Enantioselective transport and CYP3A4-mediated metabolism of R/S-verapamil in Caco-2 cell monolayers显示文摘 | Helena E Christer T Artursson P | 2003 | Eur J Pharm Sci2003，19，： | 1 |
| 11 | EDHF, NO and a prostanoid : hyperpolarization - dependent and - independent relaxation in guinea - pig arteries 显示文摘 | Marianne T Helena CP Coleman HA | 2000 | Br J Pharmacol2000，130，3： | 1 |
| 12 | The neglec- ted role of proaetive behavior and outcomes in newcomer socialization显示文摘 | Alan M S Jamie A G Helena C T | 2011 | Journal of Vocational Behavior2011，79，1： | 1 |
| 13 | Cisplatin-induced growth arrest of head and neck cancer cells correlares with increased expression of p16 and p53显示文摘 | Yip Helena T Chopra R Chakrabarti R | 2006 | Archives of Otolaryngology Head&Neck Surgery2006，132，3： | 1 |
| 14 | The effect of dietary protein replacement by crystalline amino acid on growth and nitrogen utilization of turbot Scophthalmus maximus juveniles 显示文摘 | Helena P Aires O T | 2005 | Aquaculture2005，250，： | 1 |
| 15 | How network competence and network localitm influence innovation performance显示文摘 | YEN T HELENA C | 2009 | Journal of Business & Indus- trial Marketing2009，24，1： | 1 |
| 16 | Modification of vermiculite by poly- merization and carbonization of glycerol to produce highly efficient materials for oil removal显示文摘 | Miguel de Araujo Medeiros Maria T C Sansiviero Maria Helena Araujo | 2009 | Appl Clay Sci2009，45，4： | 1 |
| 17 | Effect of the dietary essential to non-essential amino acid ratio on growth, feed utilization and nitrogen metabolism of European sea bass (Dicentrarchus labrax) 显示文摘 | Helena P Aires O T | 2006 | Aquaculture2006，256，： | 1 |
| 18 | Hydrogen production from organic waste显示文摘 | Annika T Nielsen Helena Amandusson Robert Bjorklund He - len Dannetun Jsgen Ejlertsson Lars - Gunnar Ekedahl Ingemar LundstrSm Bo H Svensson | 2001 | Hydrogen Energy2001，26，： | 1 |
| 19 | Determination of e rythromycin in gastriejuice and blood plasma by liquid chromatography and electrochemical detection显示文摘 | HELENA T BRITTMARIC E | 1995 | J Chromatogr B1995，673，： | 1 |
| 20 | Penicillin G acylase from Achromobacter sp. CCM 4824显示文摘 | Stanislav Be?ka Václav ?těpánek Rajasekar W. Vyasarayani Michal Grulich Jaroslav Mar?álek Kamila Plhá?ková Marie Dobi?ová Helena Mare?ová Martina Pla?ková Renáta Vale?ová Andrea Palyzová Anupama Datla Trupti K. Ashar Pavel Kyslík | 2014 | Applied Microbiology and Biotechnology2014，，3： | 1 |
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