3篇
您的检索式：作者名="Heliang SHEN"
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| 1 | ESTIMATING OF ORDER-RESTRICTED LOCATION PARAMETERS OF TWO-EXPONENTIAL DISTRIBUTIONS UNDER MULTIPLE TYPE-Ⅱ CENSORING显示文摘§1IntroductionSupposethatXhasatwo-parameterexponentialdistributionexp(μ1,σ1)withdensityfunctionf1(x;μ1,σ1)=1σ1exp-x-μ1σ1{},x≥... | Shen Yike\ Fei Heliang | 1999 | Applied Mathematics(A Journal of Chinese Universities)1999，14，1： | 2 |
| 2 | Low-Drift Closed-Loop Fiber Optic Gyroscope of High Scale Factor Stability Driven by Laser With External Phase Modulation显示文摘In view of the poor scale factor stability of the interferometric fiber optic gyroscope(IFOG),it is a creative method to use laser to drive the IFOG for its better frequency stabilization characteristics instead of the broadband light source.As the linewidth of laser is narrow,the errors of coherent backscattering,polarization coupling,and Kerr effect are reintroduced which cause more noise and drift.This paper studies laser spectrum broadening based on external phase modulation of Gaussian white noise(GWN).The theoretical analysis and test results indicate that this method has a good effect on spectrum broadening and can be used to improve the performance of the laser-driven IFOG.In the established closed-loop IFOG,a four-state modulation(FSM)is adopted to avoid temperature instability of the multifunction integrated-optic chip(MIOC)and drift caused by the electronic circuit in demodulation.The experimental results show that the IFOG driven by broadened laser has the angular random walk noise of 0.0038°/√h and the drift of 0.017°/h,which are 62%and 66%better than those without modulation respectively,of which the drift has reached the level of the broadband light source.Although the noise still needs further reduction,its scale factor stability is 0.38 ppm,which has an overwhelming advantage compared with the traditional IFOG. | Jingtao YAN Lijun MIAO Heliang SHEN Xiaowu SHU Tengchao HUANG Shuangliang CHE | 2022 | Photonic Sensors2022，12，3： | 1 |
| 3 | Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy显示文摘The low immunogenicity of tumors remains one of the major limitations of cancer immunotherapy.Herein,we report a bacterial metabolisminitiated and photothermal-enhanced nanocatalytic therapy strategy to completely eradicate primary tumor by triggering highly effective antitumor immune responses.Briefly,a microbiotic nanomedicine,designated as Cu_(2)O@ΔSt,has been constructed by conjugating PEGylated Cu_(2)O nanoparticles on the surface of an engineered Salmonella typhimurium strain(ΔSt).Owing to the natural hypoxia tropism ofΔSt,Cu_(2)O@ΔSt could selectively colonize hypoxic solid tumors,thus minimizing the adverse effects of the bacteria on normal tis-sues.Upon bacterial metabolism within the tumor,Cu_(2)O@ΔSt generates H_(2)S gas and other acidic substances in the tumor microenvironment(TME),which will in situ trigger the sulfidation of Cu_(2)O to form CuS facilitating tumor-specific photothermal therapy(PTT)under local NIR laser irradiation on the one hand.Meanwhile,the dissolved Cu+ions from Cu_(2)O into the acidified TME enables the nanocatalytic tumor therapy by catalyzing the Fenton-like reaction of decom-posing endogenous H_(2)O_(2) into cytotoxic hydroxyl radicals(·OH)on the other hand.Such a bacterial metabolism-triggered PTT-enhanced nanocatalytic treatment could effectively destroy tumor cells and induce a massive release of tumor antigens and damage-associated molecular patterns,thereby sensitizing tumors to checkpoint blockade(ICB)therapy.The combined nanocatalytic and ICB therapy results in the much-inhibited growth of distant and metastatic tumors,and more importantly,induces a powerful immunological memory effect after the primary tumor ablation. | Wencheng Wu Yinying Pu Shuang Gao Yucui Shen Min Zhou Heliang Yao Jianlin Shi | 2022 | Nano-Micro Letters2022，14，12： | 1 |
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