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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Bovine trophoblast protein-1 complex alters endometrial protein and prostaglandin secretion and induces an intracellular inhibitor of prostaglandin synthesis in vitro显示文摘 | Helmer S D Gross T S Newton G R | 1989 | Joumals of Reproduction & Fertility1989，，87： | 1 |
| 3 | Supercooling of poly(dimethylsiloxanes)显示文摘 | HELMER J D POLMANTEER K E | 1969 | Journal of Applied Polymer Science1969，13，： | 1 |
| 4 | Vagus nerve stimulation in pediatric epilepsy:a review显示文摘 | Valencia I Holder D L Helmers S L | | 0，，05： | 1 |
| 5 | Ketamine-induced gastroprotection during endotoxemia: role of heme-oxygenase-1显示文摘 | HELMER K S SULIBURK J W MERCER D W | 2006 | Dig Dis Sci2006，51，： | 1 |
| 6 | Use of MS2 coli-phage as a surrogate for enteric viruses in surface waters disinfected with ozone显示文摘 | Helmer R D and Finch G R | 1993 | Ozone Sci Eng1993，15，： | 1 |
| 7 | Surgeon-performed ultrasound for pneumothorax in the trauma suite显示文摘 | Knudtson J L Dort J M Helmer S D | 2004 | J Trauma2004，56，3： | 1 |
| 8 | Evaluation of fundamental properties of a silica capillary used for capillary electrophoresis显示文摘 | Salomon K Burgi D S Helmer J C | 1991 | J Chromatogr1991，559，12： | 1 |
| 9 | Checkup for aging artwork-optical tools to monitor mechanical behaviour显示文摘 | HINSCH K D GULKER G HELMERS H | 2007 | Optics and Lasers in Engineering2007，45，5： | 1 |
| 10 | A design aid for determining width of filter strips显示文摘 | DOSSKEY M G HELMERS M J EISENHAUER D E | 2008 | Journal of Soil and Water Conservation2008，63，4： | 1 |
| 11 | Factors influencinga womeng choice to undergo to breast conserving surgery ver-sus modified radical mastectomy 显示文摘 | Nold I L Beamer R L Helmer S D | 2004 | Am J Surg2004，180，6： | 1 |
| 12 | Assessing the risk of lower extremity amputations using an administrative data-based foot risk index in elderly patients with diabetes 显示文摘 | Helmer D Tseng CL Wrobel J | 2011 | J Diabetes2011，3，3： | 1 |
| 13 | YouTube as a platform for publishing clinical skills training videos 显示文摘 | Topps D Helmer J Ellaway R | 2013 | Acad Med2013，88，2： | 1 |
| 14 | Effects of oxygen-enriched nutrient solution on greenhouse cucumber and pepper production 显示文摘 | Ehret D L Edwards D Helmer T | 2010 | Scientia horticulturae2010，125，4： | 1 |
| 15 | Changes in theExtent of Surface Mining and Reclamation in the Central Appala-chians Detected Using a 1976-2006 Landsat Time Series显示文摘 | Townsend P A Helmers D P Kingdon C C | 2009 | Remote Sensing of Environment2009，113，1： | 1 |
| 16 | The Implementation and Performance of Compressed Databases 显示文摘 | Westmann T Kossmann D Helmer S | 2000 | ACM SIGMOD Record2000，29，3： | 1 |
| 17 | Determination of ratio of surface area to pore volume from restricted diffusion in a constant field gradient显示文摘 | Helmer K Hurlimann M D Deswiet T | 1995 | J Magn Reson1995，115，2： | 1 |
| 18 | A design aid for determining width of filter strips显示文摘 | DOSSKEY M G HELMERS M J EISENHAUER D E | | 0，，04： | 1 |
| 19 | A design aid for determining width of filter strips显示文摘 | Dosskey M G Helmers M J Eisenhauer D E | 2008 | Journal of Soil and water Conservation2008，63，4： | 1 |
| 20 | Seroma formation after breast cancer surgery:incidence and predicting factors 显示文摘 | Wood worth P A McBoyle M F Helmer S D | 2000 | Am Surg2000，66，5： | 1 |
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