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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Progress in the utilization of urea as a protein replacer for ruminants: A review显示文摘 | Helmer L G Bartley E E | 1971 | Journal of Dairy Science1971，54，1： | 1 |
| 3 | Supercooling of poly(dimethylsiloxanes)显示文摘 | HELMER J D POLMANTEER K E | 1969 | Journal of Applied Polymer Science1969，13，： | 1 |
| 4 | Mapping the climate of Puerto Rico, Vieques and Culebra显示文摘 | Christopher Daly E H Helmer Maya Quinones | 2003 | International Journal of Climatology2003，23，： | 1 |
| 5 | Ketamine attenuates liver injury attributed to endotoxemia:role of cyclooxygenase-2显示文摘 | SULIBURK J W HELMER K S GONZALEZ E A | 2005 | Surgery2005，138，2： | 1 |
| 6 | Root biomass allocation in the world' s upland forests 显示文摘 | Cairns M A Brown S Helmer E H | 1997 | Oecologia1997，111，： | 1 |
| 7 | Root biomass allocation in the world's upland forests显示文摘 | Cairns M A Brown S Helmer E H | 1997 | Oecologia1997，111，1： | 1 |
| 8 | CT of the intraeranial cryptocoeosis 显示文摘 | Popovich M J Arthur RH Helmer E | 1990 | AR11990，154，： | 1 |
| 9 | Root biomass allocation in the world's upland forests显示文摘 | Cairns M A Brown S Helmer E H | 1997 | Oecologia1997，11，： | 1 |
| 10 | Hospital effluents as a source for platinum and ifosfamide excretions emited into surface water via hospital effluents显示文摘 | KMMERER K HELMERS E | 1997 | Science of Total Environment1997，193，： | 1 |
| 11 | Root biomass allocation in the world's upland forests显示文摘 | Cairns M A Brown S Helmer E H | 1997 | Oecologia1997，111，： | 1 |
| 12 | Hospital effluents as a source for gadolinium in the aquatic environment显示文摘 | KMMERER K HELMERS E | 2000 | Environment Science&Technology2000，34，： | 1 |
| 13 | The natural history of stroke in diabetic patients显示文摘 | Asplund K Hagg E Helmers C | 1980 | Acta Med Scand1980，207，3： | 1 |
| 14 | Root biomass allocation in the world 's upland forests 显示文摘 | Cairns M A S Brown E H Helmer G A Baumgardner | 1997 | Oecologia1997，，111： | 1 |
| 15 | A design aid for determining width of filter strips显示文摘 | DOSSKEY M G HELMERS M J EISENHAUER D E | 2008 | Journal of Soil and Water Conservation2008，63，4： | 1 |
| 16 | Mapping the climate of Puerto Rico, Vieques and Cusehra显示文摘 | DALY C HELMER E H QUINONES M | 2003 | International Journal of Climatology2003，23，11： | 1 |
| 17 | Refractory sprue, celiac disease,and enteropathy-associated T-cell lymphoma 显示文摘 | Cellier C Delabesse E Helmer C | 2000 | Lancet2000，356，9225： | 1 |
| 18 | Root biomass allo catim in the world's upland forests显示文摘 | Cairns M A Brown S Helmer E H | 1997 | Oecologia1997，111，1： | 1 |
| 19 | Safety and efficacy of vglsartan versus enalapfil in heart failure patients显示文摘 | Willenheimer R Helmers C Pantev E | 2002 | Int J Cardiol2002，85，2： | 1 |
| 20 | Mapping the climate of Puerto Rico,Vieques and Culebra显示文摘 | Daly C Helmer E H Quinones M | 2003 | International Journal of Climatology2003，23，11： | 1 |
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