| 1 | Early detection of gastric cancer in China:progress andopportunities显示文摘In the past decade, the Chinese government has committed to promoting gastric cancer (GC) prevention and control1,2. GC is a major malignancy globally, and nearly half of GC cases and specific deaths worldwide occur in China;moreover, GC is frequently diagnosed in local advanced or advanced stages with poor prognosis3-5. GC progression is known to involve a multi-stage evolutionary cascade from precancerous gastric lesions, thus theoretically enabling the identification of high-risk populations and early detection of GC6. | Hengmin Xu Wenqing Li | 2022 | Cancer Biology & Medicine2022，19，12： | 2 |
| 2 | Effects of Chinese Herbal Compound on the Blood Physiological Indices and Cytokines of Myelosuppressive Mice显示文摘[Objective] The research aimed to study the effects of Chinese herbal compound on the blood physiological indices and cytokines of myelosuppressive mice. [Method] Myelosuppressive mice model was established by intraperitoneal injection of 80 mg / kg cyclophosphamide. Chinese herbal compound was composed of Houttuynia cordata,Taraxacum mongolicum,Citrus reticulata peel,Atractylodes chinensis,Paeonia sterniana,Atractylodes macrocephala and Angelica sinensis. The effects of Chinese herbal compound and Astragalus polysaccharide at different doses on the blood physiological indices and hematopoietic growth factors of myelosuppressive mice were discussed. [Result] Myelosuppressive mice model was successfully established. The total white blood cell count,total neutrophile granulocyte count,total lymphocyte count,total platelet count and the contents of serum interleukin-6 and erythropoietin in myelosuppressive mice were significantly decreased. The total erythrocyte count,the contents of hemoglobin and interleukin-3 were decreased,without significant difference. The blood physiological indices and the contents of interleukin-3 and erythropoietin in myelosuppressive mice could be improved by intragastric administration of Astragalus polysaccharide and Chinese herbal compound at different doses for 3 days or 7 days. The effect of 20 g / kg Chinese herbal compound was the best after administration for 3 days,and the effect of 10 g / kg Chinese herbal compound was the best after administration for 7 days. The total white blood cell count,total neutrophile granulocyte count,percentage of neutrophile granulocyte,total lymphocyte count,total count of middle cells,percentage of middle cells,total platelet count,contents of interleukin-3 and erythropoietin in myelosuppressive mice could be extremely significantly improved by intragastric administration of 10 g / kg Chinese herbal compound for 7 days( P <0. 01),and the reduction of red blood cell count,hematocrit,the contents of hemoglobin and interleukin-6 induced by cyclophosphamide could be inhibited( P <0. 01). [Conclusion] Chinese herbal compound could improve the hematopoietic function of myelosuppressive mice induced by cyclophosphamide and its effect was better than Astragalus polysaccharide. 20 g / kg Chinese herbal compound reacted fast and the reaction of 10 g / kg Chinese herbal compound was slow,but its efficacy was lasting. | Mu Xiaodong Zuo Zhicai Gan Meng Cui Hengmin Peng Xi Wang Ya Deng Junliang Xu Zhiwen | 2014 | Animal Husbandry and Feed Science2014，6，3： | 0 |
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