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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | X-ray interactions: photabsorption, scattering, transmission, and reflection at E-50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Tables1993，54，： | 2 |
| 3 | Mutation rate in human micro satellites显示文摘 | Henke J Henke L | 1999 | Am J Hum Genet1999，64，8： | 1 |
| 4 | Pathologic explanation for hypoechoic halo seen on sonograms of malignant liver tumors: An in vitro correlative study显示文摘 | Wernecke K Henke L Vassallo P | 1992 | AJR1992，158，11： | 1 |
| 5 | X-ray interactions: photoabsorption scattering, transmission and reflection at E=50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，： | 1 |
| 6 | X-ray interaction:photoabsorption,scattering,transmission and reflection at E=50-30000eV,Z=1-92显示文摘 | HENKE B L GULLIKSEN E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，2： | 1 |
| 7 | Pulsed plasma source spectrometry in the 80-8 000 eV X-ray region显示文摘 | Henke B L Yamada H T Tanaka T J | 1983 | Review of Scientific Instruments1983，54，10： | 1 |
| 8 | Application of Ychromosomal STR Haplotypes to Forensic Genetics 显示文摘 | Henke J Henke L Chatthopadhyay P | 2001 | Croat Med J2001，42，3： | 1 |
| 9 | X-ray interactions: photoabsorption, scattering, transmission, and reflection at E=50-30 000 eV, Z= 1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，2： | 1 |
| 10 | Characterization of Phenols and Indanol in Coal Derived Liquids-use of Curie Point Vaporization Gas Chromatography Mass Spectrometry显示文摘 | McClennen W H Henk L C | 1983 | Fuel1983，62，12： | 1 |
| 11 | Two-channel elliptical analyzer spectro- graph for absolute, time-resolving time-integrating spectrometry of pulsed x-ray sources in the 100-10000 eV region显示文摘 | Henke B L Jaanimagi P A | 1985 | Review of Scientific Instruments1985，56，8： | 1 |
| 12 | A paternity case with three genetic incompatibilities between father and child due to maternal uniparental disomy 21 and a mutation at the Y chromosome显示文摘 | Audrey ML Jurgen H Henke L | 2009 | Forensic Sci Int Genet2009，3，2： | 1 |
| 13 | Mass spectrometric identification of isoforms of PR proteins in xylem sap of fungus-infected tomato 显示文摘 | Martijn R Henk L Dekker | 2002 | Plant Physiology2002，130，2： | 1 |
| 14 | Pulsed plasma source spectroscopy in the 80-8000-eV X ray region显示文摘 | Henke B L Yamada H T Tanaka T J | 1983 | Review of Scientific Instruments1983，54，10： | 1 |
| 15 | A Comparison of Three Methods for Principal Component Analysis of Fuzzy Interval Data显示文摘 | Paolo Giordani Henk A L Kiers | 2006 | Com- putational Statistics & Data Analysis2006，，5： | 1 |
| 16 | Soft X ray induced secondary electron emission from semiconductors and insulators: Models and measurements显示文摘 | Henke B L Liesegang J Smith S D | 1979 | PhysRevB1979，19，6： | 1 |
| 17 | X ray interac tions: Photoabsorption, scattering, transmission, and re{lec tion at E=50-30 000 eV, Z--1 92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nu clear Data Table1993，54，2： | 1 |
| 18 | Optimization of 3- (1H-indazol-3-ylmethyl)-1, 5-benzodiazepines as potent, orally active CCK-A agonists 显示文摘 | Henke B R Aquino C J Birkemo L S | 1997 | J Med Chem1997，40，17： | 1 |
| 19 | X-ray interactions: photoabsorption, scattering, transmission, and reflection at E= 50-30 000 eV, Z= 1-92显示文摘 | Henke B L Gullikson E M Davis J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，2： | 1 |
| 20 | Characterization of Phenols and lndanol in Coal Derived Liquids-use of Curie Point Vaporization Gas Chromatography Mass Spectrometry显示文摘 | McClennen W H Henk L C | 1983 | Fuel1983，62，14： | 1 |
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