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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Mechanical thrombectomy in patients with M1 occlusion and NIHSS score≤5:a single-centre experience显示文摘Background:The recent success of several mechanical thrombectomy trials has resulted in a significant change in management for patients presenting with stroke.However,it is still unclear how to manage patients that present with stroke and low National Institutes of Health Stroke Scale(NIHSS)≤5.We sought to review our experience of mechanical thrombectomy in patients with low NIHSS and confirmed M1 occlusion.Methods:We retrospectively analysed our prospectively maintained database of all patients undergoing mechanical thrombectomy between January 2008 and August 2016.We identified 41 patients with confirmed M1 occlusion and low NIHSS(≤5)on admission to our hospital.We collected demographic,radiological,procedural and outcome data.Results:The mean age of patients was 72±14,with 20 male patients.Associated medical conditions were common with hypertension seen in∼80%.Just over 50%presented with NIHSS 4 or 5.The average ASPECTS score on admission was 8.8(range 6–10),and the average clot length 10 mm.Angiographically Thrombolysis in Cerebral Infarction(TICI)≥2b was obtained in 87.8%of patients.7 patients had haemorrhage on follow-up,2 of which were symptomatic.Of 40 patients with 90-day follow-up,75%had modified Rankin Scale(mRS)score 0–2.There were 3 deaths at 90 days.Conclusions:Mechanical thrombectomy in patients with low NIHSS and proximal large vessel occlusion is technically possible and carries a high degree of success with good safety profile.Patients with low NIHSS and confirmed occlusion should be considered for mechanical thrombectomy. | P Bhogal P Bucke O Ganslandt H Bazner H Henkes M Aguilar Perez | 2016 | Stroke & Vascular Neurology2016，1，4： | 9 |
| 3 | Increasing the electrical discharge endurance of acid anhydride cured DGEBA epoxy resin by dispersion of nanoparticle silica 显示文摘 | HENK P O KORTSEN T W KVARTS T | 1999 | High Perform Polym1999，11，： | 1 |
| 4 | Time series analysis of CO concentrations from an Eastern Kentucky coal fire显示文摘 | James C Hower Jennifer M K O’keefe Kevin R Henke | 2011 | International Journal of Coal Geology2011，88，： | 1 |
| 5 | The Tiptop coal-mine fire,Kentucky:Preliminary investigation of the measurement of mercury and other hazardous gases from coalfire gas vents显示文摘 | James C Hower Kevin Henke Jennifer M K O’keefe | 2009 | International Journal of Coal Geology2009，80，： | 1 |
| 6 | CO2,CO,and Hg emissions from Truman Shepherd and Ruth Mullins coal fires,eastern Kentucky,USA显示文摘 | Jennifer M K O’keefe Kevin R Henke James C Hower | 2010 | Science of the Total Environment2010，408，： | 1 |
| 7 | Increasing the electrical discharge endurance of acid anhydride cured DGEBA epoxy resin by dispersion of nanoparticle silica 显示文摘 | P O Henk T W Kortsen T Kvarts | 1999 | High Perform Polym1999，，11： | 1 |
| 8 | Immunomodulatory activity and effectiveness of macrolides in chronic airway disease显示文摘 | Rubin B K Henke M O | 2004 | Chest2004，125，2： | 1 |
| 9 | A comparison of functional and physical properties of self-expanding intracranial stents 显示文摘 | Krischek O Miloslavski E Fischer S Shrivastava S Henkes H | 2011 | Minim Invasive Neurosurg2011，54，： | 1 |
| 10 | Increasing the electrical discharge endurance of Acid Anhydride cured DGEBA epoxy resin by dispersion of nanoparticle silica显示文摘 | Henk P O Kortsen T W Kvarts T | 1999 | High Perform Polym1999，11，3： | 1 |
| 11 | Assessment of dural arteriovenous fistulae by transcranial colorcoded duplex sonography显示文摘 | Harrer J Popescu O Henkes H | 2005 | Stroke2005，36，： | 1 |
| 12 | Forests as a mirror of rural conditions; local views on the role of forests across Europe显示文摘 | Birgit H M Elands Tom~s N O'Leary Henk W J Boerwinkel | 2004 | Forest Policy and Economics2004，6，5： | 1 |
| 13 | Uhrasonography and clinical observation in women with suspected acute appendicitis: a prospective cohort study 显示文摘 | Pieter P Henk O Paul L | 2009 | Dig Surg2009，26，2： | 1 |
| 14 | Listeria monocytogenes lineages: genomics, evolution, ecology, and phenotypic characteristics 显示文摘 | Renato H O Henk C d B Martin W | 2011 | International Journal of Medical Microbiology2011，301，： | 1 |
| 15 | Increasing the electrical discharge endurance of acid anhydride cured DGEBA epoxy resin by dispersion of nanopartiele silica显示文摘 | Henk P O Kortsen T W Kvarts T | 1999 | High Performance Polymers1999，11，3： | 1 |
| 16 | Immunomodulatory activity and effectiveness of macrolides in chronicairway disease 显示文摘 | Bruce K Rubin Mengr MD FCCP Markus O Henke MD | 2004 | CHEST2004，125，： | 1 |
| 17 | MUC 5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerba- tion 显示文摘 | HENKE MARKUS O JOHN GERRIT GERMANN MICHELE | 2007 | American Journeal of Respiratory and Critical Care Medicine2007，175，8： | 1 |
| 18 | Using activity analysis to locate profitability drivers显示文摘 | Spoede C Henke E O Umble M | 1994 | Management Accounting1994，，5： | 1 |
| 19 | CO 2 , CO, and Hg emissions from the Truman Shepherd and Ruth Mullins coal fires, eastern Kentucky, USA显示文摘 | Jennifer M.K. O’Keefe Kevin R. Henke James C. Hower Mark A. Engle Glenn B. Stracher J.D. Stucker Jordan W. Drew Wayne D. Staggs Tiffany M. Murray Maxwell L. Hammond Kenneth D. Adkins Bailey J. Mullins Edward W. Lemley | 2009 | Science of the Total Environment2009，，7： | 1 |
| 20 | macrolide antibi- otics as immunomodulatory medications : proposed mechanisms of action显示文摘 | SH1NKAI M HENKE M O RUBIN B K | 2008 | Pharmacol Ther2008，117，3： | 1 |
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