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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Quantitative susceptibility of Streptococcus suis strains isolated from diseased pigs in seven European countries to antimicrobial agents licenced in veterinary medicine显示文摘 | Henk J W Kees T V Chris V E | 2006 | Veterinary Microbiology2006，113，： | 1 |
| 3 | Cell density of human lens epithelium in women higher than in men 显示文摘 | Guggenmoos-Hoizmann I Engel B Henke V | 1989 | Invest Ophthalmol Vis Sci1989，30，： | 1 |
| 4 | Amplification in service supply chains: an exploratory case study from the telecom industry 显示文摘 | Henk Akkermans Bart V | 2003 | Production And Operations Management2003，12，2： | 1 |
| 5 | A validation study of a retro- spective venous thromboembolism risk scoring method显示文摘 | Bahl V Hu HM Henke PK | 2010 | Ann Surg2010，251，2： | 1 |
| 6 | A validation study of aretrospective venous thromboembolism risk scoring method显示文摘 | Bahl V Hu H M Henke P K | 2010 | Ann Surg2010，251，2： | 1 |
| 7 | Reciprocal Altruism Under Conditions of Partner Selection显示文摘 | Henk D V Smaniotto R Elsas D A | 2001 | Rationality and Society2001，13，2： | 1 |
| 8 | Neuro-fuzzy methods for nonlinear system identification显示文摘 | ROBERT B HENK V | 2003 | Ann Rev in Control2003，27，： | 1 |
| 9 | Exploring root developmental plasticity to nitrogen with a three-dimensional architectural model 显示文摘 | Henke M Sarlikioti V Kurth W | 2014 | Plant and Soil2014，385，： | 1 |
| 10 | Progress in Mastery of Counseling Communication Skills显示文摘 | Jeroen K Molen V Henk T | | 0，，24： | 1 |
| 11 | Exposure-response relation- ships for transportation noise 显示文摘 | Henk M E M Henk V | 1998 | Acoustical Society of America1998，104，6： | 1 |
| 12 | A Practical Protocol for AdvantageDistillation and Information Reconciliation显示文摘 | Liu S Henk C A Tilborg V | 2003 | Designs Codes andCryptography2003，30，： | 1 |
| 13 | Construct support vector machine ensemble to detect traffic incident显示文摘 | CHEN S Y WANG W HENK V Z | 2009 | Expert Systems with Applications2009，36，10： | 1 |
| 14 | Iterative solution of linear systems in the 20th century显示文摘 | Saad Y Henk A Vorst V D | 2000 | Journal of Computational and Applied Mathematics2000，123，2000： | 1 |
| 15 | Quantification of crack-healing in novel bacteria-based self-healing concrete 显示文摘 | Wiktor V Henk M Jonkers H M | 2011 | Cement Concrete Composites2011，33，7： | 1 |
| 16 | Construct support vector machine ensemble to detect traffic incident 显示文摘 | Chen S Y Wang W Henk V Z | 2009 | Expert Systems with Applications2009，36，10： | 1 |
| 17 | A validation study of a retrospective venous thromboembolism risk scoring me- thod显示文摘 | Bahl V Hu HM Henke PK | 2010 | Ann Surg2010，251，2： | 1 |
| 18 | A validation study of a retrospective venous thromboembolism risk scoring method 显示文摘 | Bahl V Hu HM Henke PK | 2010 | Ann Surg2010，251，2： | 1 |
| 19 | A validation study of a retrospective venous thromboembolism risk scoring method 显示文摘 | Bahl V Hu HM Henke PK | 2009 | Ann Surg2009，251，2： | 1 |
| 20 | Avian defensins 显示文摘 | Albert van D Edwin J A V Henk P H | 2008 | Veterinary Im- munology and lrmnunopathology2008，124，12： | 1 |
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