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| 1 | 不同程度慢性牙周炎患者病情的二年自然进展显示文摘目的 观察不同程度慢性牙周炎的自然进展规律。方法 纵向观察 16 9例轻、中、重度慢性牙周炎患者在 2年中的疾病自然进展 ,检查除第三磨牙外的全口牙 ,每颗牙 6个位点 ,以探诊深度、附着丧失为指标 ,两次检查之间附着丧失加重≥ 3mm的牙位定为活动性进展。结果 活动性发生率依基线时疾病的轻、中、重程度而逐渐增高 ,按位点活动性的发生率分别为 0 14 %、0 39%及0 73% ,按个体活动性的发生率分别为 15 5 6 %、2 9 89%及 4 3 2 4 % ,差异有统计学意义。结论 重度牙周炎患者是牙周破坏活动性进展的高危人群。 | 欧阳翔英 曹采方 Henry Liu 胡文杰 J Leslie Winston | 2004 | 中华口腔医学杂志2004，39，3： | 24 |
| 2 | 极端干旱区花花柴(Karelinia caspia)、骆驼刺(Alhagi sparsifolia)和胡杨(Populus euphratica)叶片凋落物分解特征显示文摘为探究极端干旱区凋落物分解特征,利用凋落物分解袋法,以塔克拉玛干南缘策勒绿洲边缘荒漠地区优势植物花花柴(Karelinia caspia)、骆驼刺(Alhagi sparsifolia)和胡杨(Populus euphratica)的叶片凋落物为对象进行分解试验,探究极端干旱区凋落物分解特征及主要影响因素。结果表明:(1)极端干旱区凋落物分解主要在凋落次年的5—9月,有机物的损失是质量损失的重要原因;(2)对于水溶性盐含量较高的凋落物,水溶性盐损失在质量损失中占较高比例;(3)降雨是影响极端干旱区凋落物分解的重要因素,降雨与凋落物分解的Pearson相关性显著高于温度和太阳辐射。 | 李成道 李向义 Henry J Sun 李磊 林丽莎 | 2019 | 中国沙漠2019，39，2： | 10 |
| 3 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 4 | Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials显示文摘 | Guglielmo Ronco Joakim Dillner K Miriam Elfstr?m Sara Tunesi Peter J F Snijders Marc Arbyn Henry Kitchener Nereo Segnan Clare Gilham Paolo Giorgi-Rossi Johannes Berkhof Julian Peto Chris J L M Meijer | 2013 | The Lancet2013，，： | 3 |
| 5 | 外用辣椒素治疗慢性疼痛:系统性综述显示文摘评价局部应用辣椒素治疗神经及肌肉骨骼功能失调引起的慢性疼痛的疗效和安全性。 | Lorna Mason R Andrew Moore Sheena Derry Jayne E Edwards Henry J Mcquay 孙静 | 2004 | 英国医学杂志中文版2004，7，5： | 3 |
| 6 | Near stoichiometric silicon carbide from an economical polysilane precursor显示文摘 | SEYFERTH D TIMOTHY G HENRY J | 1992 | J Am Ceram Soc1992，75，5： | 2 |
| 7 | Determination of basal ileal endogenous losses and standardized ileal digestibility of amino acids in barley fed to growing pigs显示文摘Background: Basal ileal endogenous amino acid(AA) losses(IAA_(end)) and standardized ileal digestibility(SID) values of cereal grains, such as barley, are apparently underestimated when determined according to the nitrogen(N)-free method. Regression analysis between the dietary apparent ileal digestible content(c AID) and total crude protein(CP) and AA can be considered as alternative approach to obtain more accurate values for IAA_(end)and SID of AA in cereal grains.Methods: Eight hulled barley genotypes were used, with barley being the only source of CP and AA in the assay diets. The diets contained 95 % as-fed of these eight barley genotypes each, ranging in CP content between 109.1 and 123.8 g/kg dry matter(DM). Nine ileally T-cannulated barrows, average body weight(BW) 30 ± 2 kg, were allotted to a row-column design comprising eight periods with 6 d each and nine pigs. On d 5 and the night of d 6 of every period, ileal digesta were collected for a total of 12 h. The IAA_(end) and the SID were determined by linear regression analysis between c AID and total dietary CP and AA.Results: There exist linear relationships between cA ID and total CP and AA(P < 0.001). The IAA_(end) of CP, Lys, Met, Thr and Trp amounted to 35.34, 1.08, 0.25, 1.02 and 0.38 g/kg DM intake(DMI), respectively, which are greater compared to average IAA_(end) determined previously under N-free feeding conditions. The SID of CP, Lys, Met, Thr and Trp was 90,79, 85, 79 and 86 %, respectively, and was greater when compared to tabulated values. Moreover, these SID values were greater than those reported in literature, based on correction of apparent ileal digestibility(AID) of CP and AA for their IAA_(end)values. Summarized, the results of the present regression analysis indicate greater IAA_(end)in barley-based diets compared to those obtained by N-free feeding.Conclusions: For low-protein feed ingredients like barley the regression method may be preferred over correction of AID values for their IAA_(end)determined under N-free feeding conditions, as intercepts and slopes of the linear regression equations between cA ID and total dietary CP and AA provide direct estimates of IAA_(end)and SID of CP and AA in the presence of the assay feed ingredient. | Hanna Katharina Spindler Rainer Mosenthin Pia Rosenfelder Henry J?rgensen Knud Erik Bach Knudsen Meike Eklund | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 2 |
| 8 | Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome显示文摘 | Mark Pimentel Evelyn J Chow Henry C Lin | 2003 | The American Journal of Gastroenterology2003，，2： | 2 |
| 9 | Reoperation for prosthetic aortic valve obstruction in the era of echocardiography: trends in diagnostic testing and comparison with surgical findings显示文摘 | Steven E Girard Fletcher A Miller Thomas A Orszulak Charles J Mullany Samantha Montgomery William D Edwards Henry D Tazelaar Joseph F Malouf A.Jamil Tajik | 2001 | Journal of the American College of Cardiology2001，，2： | 2 |
| 10 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 11 | Emergence in Asia of foot-and-mouth disease viruses with altered host range:characterization of alteration in the 3A protein显示文摘 | Knowles N J Davies P R Henry T | 2001 | J Virol2001，75，3： | 2 |
| 12 | Burkholderia cepacia genomovar Ⅵ, a new member of the Burkholderia cepacia complex isolated from cystic fibrosis patients显示文摘 | Coenye T Lipuma J J Henry D | 2001 | International Journal of Systematic and Evolutionary Microbiology2001，51，： | 1 |
| 13 | The analysis of observed chaotic data in physical systems 显示文摘 | Abarbanel Henry D I Brown R Sidorowich J J | 1993 | Rev Mod Phy (S0034-6861)1993，65，4： | 1 |
| 14 | Effect of protein and lysine levels in the diet on body gain composition and energy utilization in growing pigs 显示文摘 | Noblet J Henry Y Dubois S | 1987 | Journal of Animal Science1987，65，3： | 1 |
| 15 | Evidence for tonic activation of NK-1 receptors during the second phase of the tormalin test in the rat显示文摘 | Henry J L Yashpal K Pitcher G M | 1999 | J Neurosci1999，19，15： | 1 |
| 16 | Presurgical evaluation for partial epilepsy: relative contributions of chronic depth-electrode recordings versus FDG-PET and scalp-sphenoidal ictal EEG显示文摘 | Henry TR Risinger MW | 1990 | Neurology1990，40，： | 1 |
| 17 | A perfect marker for fragrance genotyping in rice显示文摘 | Bradbury L M T Henry R J Jin Q S | 2005 | Molecular Breeding2005，16，： | 1 |
| 18 | Neutron powder dif- fraction of carbon-coated FeCo alloy nanoparticles显示文摘 | HENRY JOHN SCOTTA J KRISHNA | 1999 | J Appl phys1999，85，8： | 1 |
| 19 | Long-term follow-up of pseud-oexfoliation and the development of elevated intraocular pres-sure显示文摘 | Henry J C Krupin T Schmitt M | 1987 | Ophthalmology1987，94，： | 1 |
| 20 | Pairwise sequence alignment using a PROSITE pattern-derived similarity score 显示文摘 | Comet J P Henry J | 2002 | Computers & Chemistry2002，26，： | 1 |
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