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| 1 | Serum bicarbonate may independently predict acute kidney injury in critically ill patients:An observational study显示文摘AIM: To explore whether serum bicarbonate at admission to intensive care unit(ICU) predicted development of acute kidney injury(AKI).METHODS:We studied all patients admitted to our ICU over a 2 year period(February 2010 to 2012).The ICU has a case mix of medical and surgical patients excluding cardiac surgical,trauma and neurosurgical patients.We analysed 2035 consecutive patients admitted to ICU during the study period.Data were collected by two investigators independently and in duplicate using a standardised spread sheet to ensure accuracy.Ambiguous data were checked for accuracy where indicated.AKI was defined using the Kidney Disease Improving Global Outcomes criteria.Patients were divided into two groups;patients who developed AKI or those who did not,in order to compare the baseline characteristics,and laboratory and physiologic data of the two cohorts.Regression analysis was used to identify if serum bicarbonate on admission predicted the development of AKI.RESULTS:Of 2036 patients 152(7.5%)were excluded due to missing data.AKI developed in 43.1%of the patients.The AKI group,compared to the nonAKI group,was sicker based on their lower systolic,diastolic and mean arterial pressures and a higher acutephysiology and chronic health evaluation(APACHE)Ⅲand SAPSⅡscores.Moreover,patients who developed AKI had more co-morbidities and a higher proportion of patients who developed AKI required mechanical ventilation.The multi-regression analysis of independent variables showed that serum bicarbonate on admission(OR=0.821;95%CI:0.796-0.846;P<0.0001),APACHEⅢ(OR=1.011;95%CI:1.007-1.015;P<0.0001),age(OR=1.016;95%CI:1.008-1.024;P<0.0001)and presence of sepsis at ICU admission(OR=2.819;95%CI:2.122-23.744;P=0.004)were each significant independent predictors of AKI.The area under the ROC curve was 0.8(95%CI:0.78-0.83),thereby demonstrating that the predictive model has relatively good discriminating power for predicting AKI.CONCLUSION:Serum bicarbonate on admission may independently be used to make a diagnosis of AKI. | Anuksha Gujadhur Ravindranath Tiruvoipati Elizabeth Cole Saada Malouf Erum Sahid Ansari Kim Wong | 2015 | World Journal of Critical Care Medicine2015，4，1： | 3 |
| 2 | Reoperation for prosthetic aortic valve obstruction in the era of echocardiography: trends in diagnostic testing and comparison with surgical findings显示文摘 | Steven E Girard Fletcher A Miller Thomas A Orszulak Charles J Mullany Samantha Montgomery William D Edwards Henry D Tazelaar Joseph F Malouf A.Jamil Tajik | 2001 | Journal of the American College of Cardiology2001，，2： | 2 |
| 3 | Prospective assessment of accuracy of endoanal MR imaging and endosonography in patients with fecal incontinence显示文摘 | Williams AB Halligan S | 2000 | AJR Am J Roentgenol2000，175，3： | 1 |
| 4 | Noninvasive assessment of pulmonary vascular resistance using Doppler tissue imaging of the tricuspid annulus显示文摘 | Malouf PJ Kahn AM | 2007 | J Am Soc Echocardiogr2007，20，10： | 1 |
| 5 | An investigatordriven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis显示文摘 | Malouf MA Hopkins P Snell G | 2011 | Respirology2011，16，3： | 1 |
| 6 | Adult-derived stem cells from the liver become myocytes in the heart in vivo显示文摘 | Malouf NN Coleman WB Grisham JW | 2001 | Am J Pathol2001，158，6： | 1 |
| 7 | Comprehensive analysis of long non- coding RNAs in human breast cancer clinical subtypes 显示文摘 | Su X Malouf GG Chen Y | 2014 | Oncotarget2014，5，20： | 1 |
| 8 | Utility of right ventricular Tei index in the noninvasive evaluation of chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy 显示文摘 | Blanchard DG Malouf PJ Gurudevan SV | 2009 | J ACCCardiovasc Imaging2009，12，2： | 1 |
| 9 | Injectable silicone biomaterial for fecal incontinence duo to internal anal sphincter dysfunction 显示文摘 | KENEFICK N J WAIZEY C J MALOUF A J | 2002 | Gut2002，51，： | 1 |
| 10 | Adult-derived stem cells from the liver become myocytes in the heart in vivo 显示文摘 | Malouf NN Coleman WB Grisham JW | 2001 | Am J Pathol2001，158，6： | 1 |
| 11 | Aortic valve stenosis in community medical practice: determinants of outcome and implica- tions for aortic valve replacement 显示文摘 | Malouf J Le Tourneau T Pellikka P et at | 2012 | J Thorac Cardiovasc Surg2012，144，6： | 1 |
| 12 | BRAF inhibitor rechallenge in patients with advmwed BRAF V600-mutant melanoma显示文摘 | Roux J Pages C Malouf D | 2015 | Mela- noma Res2015，29，5： | 1 |
| 13 | Adult-drived stem cells from the liver become myocytes in the heart显示文摘 | COLEMAN W B GRISHAM J W | 2001 | American Journal of Pathology2001，158，6： | 1 |
| 14 | Primary fibroblast cellcultures from Transbronchial biopsies of lung transplant re-cipients显示文摘 | Tamm M Roth M Malouf M | 2001 | Transplantation2001，71，2： | 1 |
| 15 | Game-Theoretic models and the role of information in bargaining显示文摘 | Roth A.E Malouf M.W.K | | 0，，： | 1 |
| 16 | Association of Atrial Fibrillation and Obstructive Sleep Apnea显示文摘 | Apoor S. Gami Gregg Pressman Sean M. Caples Ravi Kanagala Joseph J. Gard Diane E. Davison Joseph F. Malouf Naser M. Ammash Paul A. Friedman Virend K. Somers | 2004 | Circulation2004，，4： | 1 |
| 17 | Impact of adjuvant treatment modalities on the management of patients with stages I-II endometrial stromal sarcoma显示文摘 | Malouf GG Duclos J Rey A | 2010 | Ann Oncol2010，21，： | 1 |
| 18 | The peptidomim- eric CXCR4 antagonist TC14012 recruits beta - arrestin to CX- CR7: roles of receptor domains 显示文摘 | GRAVEL S MALOUF C BOULAIS P E | 2010 | J Biol Chem2010，285，37： | 1 |
| 19 | Inhaled beclomethasone versus placebo for chronic asthma显示文摘 | Adams NP Bestall JB Malouf R | 2005 | Cochrane Database Syst Rev2005，25，1： | 1 |
| 20 | Histone deacetylase inhibitors as antineoplastic agents 显示文摘 | Batty N Malouf G G Issa J P | 2009 | Cancer Lett2009，280，1： | 1 |
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