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| 1 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 2 | Identifying patients, on the first day of life, at high-risk of developing parcntcral nutri- tion-associated liver disease 显示文摘 | Christcnscn RD Henry E Wiedmeier SE | 2007 | J Perinatol2007，27，5： | 1 |
| 3 | Linking maternal platelet counts with neonatal platdet counts and outcomes using the data repositories of a multihospital health care system显示文摘 | Jensen JD Wiedmeier SE Henry E | 2011 | Am J Perinatol2011，28，8： | 1 |
| 4 | Intramedullary supracondylar nailing of femoral fractures: a preliminary report of the GSH supracondylar nail显示文摘 | Seligson D Henry S | 1993 | Clin Orthop1993，296，： | 1 |
| 5 | Identifyingpatients, on the first day of life, at high-risk of developing parenteral nutrition-associated liver disease显示文摘 | Christensen RD Henry E Wiedmeier SE | 2007 | J Perinatol2007，27，5： | 1 |
| 6 | Thrombocytopenia among extremely low birth weight neonates : Data from a muhihospital heahhcare system 显示文摘 | Christensen RD Henry E Wiedmeier SE | 2006 | J Perinatol2006，26，6： | 1 |
| 7 | Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system显示文摘 | Wiedmeier SE Henry E Sola-Visner MC | 2009 | J Perinatol2009，29，2： | 1 |
| 8 | Role of glycogen synthase kinase- 3 in skeletal muscle insulin resistance in Type 2 diabetes显示文摘 | Ciaraldi TP Nikoulina SE Henry RR | 2002 | Journal of Diabetes and its Complications2002，16，： | 1 |
| 9 | ldenfifying patients, on the first day of life, at high-risk of developing parenteral nutrition-associated liver disease 显示文摘 | Christensen RD Henry E Wiedmeier SE | 2007 | J Perinatol2007，27，5： | 1 |
| 10 | Intramedullary supracondylar nailing of femoral fractures显示文摘 | Lucas SE Seligson D Henry SL | 1993 | Clin Orthop1993，296，11： | 1 |
| 11 | Outcomes following radial head arthroplasty显示文摘 | Fowler JR Henry SE Xu P | 2016 | Orthopedics2016，39，3： | 1 |
| 12 | Retrograde ejaculation after anterior lumbar spine surgery显示文摘 | Lindley EM McBeth ZL Henry SE | 2012 | Spine (Phila Pa 1976)2012，37，20： | 1 |
| 13 | Linking maternal platelet counts with neonatal piatelet counts and outcomes using the data repositories of a multihospital health care system显示文摘 | Jensen JD Wiedmeier SE Henry E | 2011 | Am J Perinatol2011，28，8： | 1 |
| 14 | Low blood neutrophil concentrations among extremely low birth weight neonates:data from a multihospital health-care system显示文摘 | Christensen RD Henry E Wiedmeier SE | 2006 | J PerinatoI2006，26，11： | 1 |
| 15 | Uncomplicated stereotactic and open neurosurgical procedures in patients with factor Ⅶ deficiency显示文摘 | Doran SE Henry TR Bockenstedt PL | | 0，，01： | 1 |
| 16 | Retrograde ejaculation after anterior lumbar spine surgery 显示文摘 | Lindley EM McBeth ZL Henry SE | 2012 | Spine ( Phila Pa 1976 )2012，20，： | 1 |
| 17 | Sex and habitat specific responses of a high arctic willow, Salix arctica, to experimental climate change 显示文摘 | Jones MH Macdonald SE Henry GHR | 1999 | Oikos1999，87，： | 1 |
| 18 | Growth performance and brain neurotransmitters in pigs as affected by tryptophan,protein,and sex显示文摘 | Henry Y Se、ve B Mounier A | 1996 | J Anum Sci1996，74，： | 1 |
| 19 | Additional Evidence Equity Ownership and Corporate Value 显示文摘 | Mcconnell Joth Henri SE | 1990 | Journal of Financial Economics1990，，27： | 1 |
| 20 | Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type Ⅱ diabetes:role of chronic hyperinsulinemia and hyperglycemia显示文摘 | Nikoulina SE Ciaraldi TP Abrams-Carter L Mudaliar S Park KS Henry RR | 1997 | Diabetes1997，46，： | 1 |
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