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| 1 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 2 | Animal plant warfare and secondary metabolite evolution显示文摘The enduring discussion,why plants produce secondary metabolites with pharmacologically and toxicologically active towards mammals traces back to the eminent role of medicinal plants in the millennia-old history of manhood.In recent years,the concept of an animal plant warfare emerged,which focused on the co-evolution between plants and herbivores.As a reaction to herbivory,plants developed mechanical defenses such as thorns and hard shells,which paved the way for adapted animal physiques.Plants evolved further defense systems by producing chemicals that exert toxic effects on the animals that ingest them.As a result of this selective pressure,animals developed special enzymes,e.g.cytochrome P450 monooxigenases(CYP450)that metabolize xenobiotic phytochemicals.As a next step in the evolutionary competition between plants and animals,plants evolved to produce non-toxic pro-drugs,which become toxic only after ingestion by animals through metabolization by enzymes such as CYP450.Because these sequestered evolutionary developments call to mind an arms race,the term animal plant warfare has been coined.The evolutionary competition between plants and animals may help to better understand the modes of action of medicinal plants and to foster the efficient and safe use of phytotherapy nowadays. | Steffen WÖLL Sun Hee KIM Henry Johannes GRETEN Thomas EFFERTH | 2013 | Natural Products and Bioprospecting2013，3，1： | 2 |
| 3 | Integrated testing of the NOXSO process: Simultaneous removed of SO2 and NOx from flue gas 显示文摘 | Yeh James T Ma Warren T Pennline Henry W | 1992 | Chem Eng Comm1992，14，： | 2 |
| 4 | Report of the joint internatonal society ant feddration of cardiology/World health lr-ganization task force on recommendation for standardiztion of measurements from M-mode eshocatdiongrans显示文摘 | Henry W N | 1984 | Circulation1984，69，3： | 1 |
| 5 | Curing(hardening,polymerization)of the POLYMER-BIODUR S10显示文摘 | WEIGLEIN A HENRY R W | 1993 | J Int Soc Plastination1993，7，： | 1 |
| 6 | Use of biosolids in the forest: Technology, economics and regulations显示文摘 | HENRY C L COLE D W | 1997 | Biomass and Bioenergy1997，13，4： | 1 |
| 7 | Phycocyanin: laser aetiviation cytotoxic effects and uptake in human athersclerotic plague显示文摘 | MORCOS N C BERNS M HENRY W L | 1998 | Lasers Surg Med1998，8，1： | 1 |
| 8 | A model-based map of ground tem-perature for the permafrost regions of Canada显示文摘 | Henry K A Smith M W | 2001 | Permafrostand Periglacial Processes2001，12，： | 1 |
| 9 | New filtration process cuts contaminants from offshore produced water 显示文摘 | Mi S A Henry L R Darlington J W | 1998 | Oil and Gas Journal1998，96，44： | 1 |
| 10 | Scattering of electrons by C, N, O, N+ , O+ , and O++ 显示文摘 | Ronald J W Henry Lipsky L | 1967 | Phys Rev1967，178，： | 1 |
| 11 | Dikehosted ores of the Beast deposit and the importance of Eocene magmatism in gold mineralization of the Carlin trend, Nevada 显示文摘 | Ressel M W Noble D C Henry C D | 2000 | Economic Geology2000，，95： | 1 |
| 12 | Four decades of protective clothing development and standardization显示文摘 | Henry N W | 2007 | J Chem Health Safety2007，5，3： | 1 |
| 13 | Polyester plastination of biological tissue:hoffen P45 technique显示文摘 | SUI H HENRY R W | 2007 | J Int Soc Plastination2007，22，： | 1 |
| 14 | chesbrough, Why Companies Should Have Open Business Model显示文摘 | Henry W | 2007 | MIT Sloan Management Review2007，2007，48： | 1 |
| 15 | Siliciclastic sequence stratigraphy and peotroleum geology-where to form here 显示文摘 | Henry W Posamentier Paul Weimer | 1993 | AAPG Bulletin1993，77，5： | 1 |
| 16 | Fever in acute pulmonary embolism显示文摘 | Stein P Afzal A Henry W | 2000 | Chest2000，117，3： | 1 |
| 17 | Demonstretion of ion figuring process 显示文摘 | Lynn N Allen Henry W Roming | 1990 | SPIE: Advanced Optical Manufacturing and Testing1990，1333，： | 1 |
| 18 | MAUT-Based dispute resolution selection model prototype for international construction projects显示文摘 | Edwin H W Chan Henry C H Suen Charles K L Chan | 2006 | Journal of Construction Engineering and Management2006，132，5： | 1 |
| 19 | Igneous Geology of the Carlin Trend,Nevada:Development of the Eocene Plutonic Complex and Significance for Carlin-Type Gold Deposits显示文摘 | Ressel M W Henry C D | 2006 | Economic Geology2006，101，： | 1 |
| 20 | Relation between echocardiographically determined left atrial size and atrial fibrillation 显示文摘 | Henry W L Morganroh J Pearlman A | 1976 | Circulation1976，53，2： | 1 |
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