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| 1 | Chronic stress sensitizes rats to pancreatitis induced by cerulein:Role of TNF-α显示文摘AIM:To investigate chronic stress as a susceptibility factor for developing pancreatitis,as well as tumor necrosis factor-α (TNF-α) as a putative sensitizer.METHODS:Rat pancreatic acini were used to analyze the influence of TNF-α on submaximal (50 pmol/L) cholecystokinin (CCK) stimulation.Chronic restraint (4 h every day for 21 d) was used to evaluate the effects of submaximal (0.2 μg/kg per hour) cerulein stimulation on chronically stressed rats.RESULTS:In vitro exposure of pancreatic acini toTNF-α disorganized the actin cytoskeleton.This was further increased by TNF-α/CCK treatment,which additionally reduced amylase secretion,and increased trypsin and nuclear factor-κB activities in a protein-kinase-C δ and ε-dependent manner.TNF-α/CCK also enhanced caspases' activity and lactate dehydrogenase release,induced ATP loss,and augmented the ADP/ATP ratio.In vivo,rats under chronic restraint exhibited elevated serum and pancreatic TNF-α levels.Serum,pancreatic,and lung inflammatory parameters,as well as caspases' activity in pancreatic and lung tissue,were substantially enhanced in stressed/cerulein-treated rats,which also experienced tissues' ATP loss and greater ADP/ATP ratios.Histological examination revealed that stressed/cerulein-treated animals developed abundant pancreatic and lung edema,hemorrhage and leukocyte infiltrate,and pancreatic necrosis.Pancreatitis severity was greatly decreased by treating animals with an anti-TNF-αantibody,which diminished all inflammatory parameters,histopathological scores,and apoptotic/necrotic markers in stressed/cerulein-treated rats.CONCLUSION:In rats,chronic stress increases susceptibility for developing pancreatitis,which involves TNF-α sensitization of pancreatic acinar cells to undergo injury by physiological cerulein stimulation. | Marcelo G Binker Andres A Binker-Cosen Daniel Richards Herbert Y Gaisano Rodica H de Cosen Laura I Cosen-Binker | 2010 | World Journal of Gastroenterology2010，16，44： | 7 |
| 2 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 3 | 澳大利亚初级保健诊所新发腰背痛患者的预后:起始队列研究显示文摘目的估计初级保健诊所内新发腰背痛患者的1年预后,并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者(平均年龄43.3岁,男性54.8%)。该起始队列患者腰背痛时间不足两周,征集自170名全科医生、理疗师或按摩师诊所。主要评估指标参试者完成基线调查问卷后,分别于初次就诊后6周、3个月和21个月时复查评估。评估内容包括:工作恢复情况、功能恢复情况和疼痛消失情况。潜在预后因素与恢复所需时间的关联性用Cox回归建模分析。结果12个月随访率〉97%。基线时工作能力下降的患者半数在14天内恢复了以前的工作状态(95%可信区间11-17天),83%在3个月内恢复。残疾(中位恢复时间31天,25-37天)和疼痛(中位58天,52-63天)则需要较长的时间才能恢复。只有72%的受试者于基线访问后12个月获得完全康复。高龄、赔偿诉讼、疼痛较重、就诊前腰背痛时间较长、就诊前因疼痛活动减少天数较多、抑郁情绪以及预期危险持续与所需恢复时问较长相关。结论在这个急性腰背痛初级保健患者队列,患者的预后并不像临床指南声称的那样乐观。多数患者的恢复缓慢。近三分之一的患者在腰背痛发作后1年尚未恢复。 | Nicholas Henschke Christopher G Maher Kathryn M Refshauge Robert D Herbert Robert G Cumming Jane Bleasel John York Anurina Das James H McAuley 蓝恭涛(译) | 2008 | 英国医学杂志中文版2008，11，6： | 2 |
| 4 | Current management of intraventricular hemorrhage显示文摘 | Herbert H Engelhard Carlota O Andrews Konstantin V Slavin Fady T Charbel | 2003 | Surgical Neurology2003，，1： | 2 |
| 5 | Adaptive changes of the rat liver cells induced by repeated intraperitoneal injections of d-galactosamine显示文摘 | Hideaki Enzan Brigitte H?berle Karin Meinhardt Christian Schuchhardt Herbert K. Koch Rainer Lesch | 1978 | Virchows Archiv B Cell Pathology1978，，1： | 2 |
| 6 | 基于神经网络和光流场的嵌入式高速目标识别与跟踪(英文)显示文摘研究了面向嵌入式硬件平台的高速视频图像处理与高速目标跟踪算法。基于神经网络的光流场算法能有效减少程序对硬件系统的内存要求和运算要求,该算法能够比传统算法更加容易的应用于以DSP(数字信号处理)芯片为核心的嵌入式硬件平台中。首先设计了一个基于Hopfield神经网络控制器的自适应滤波器,以图像信噪比为控制指标,对需进行目标识别的视频图像进行图像预处理;然后,利用补偿模糊神经网络控制器对光流场计算方法进行优化,这是一种通过参数控制平滑度实现的平均速度的角度误差和标准角误差的CFNN(补偿模糊神经网络)控制器识别跟踪算法。微机仿真及嵌入式系统试验结果均表明:该算法能够在同等条件下显著提高目标辨别与跟踪能力,显示其具有较高的有效性和实用性。 | 苏金泷 HERBERT H C IU FERNANDO T | 2015 | 中国公路学报2015，28，11： | 2 |
| 7 | Periprosthetic femoral fractures classification and demographics of 1049 periprosthetic femoral fractures from the Swedish National Hip Arthroplasty Register显示文摘 | Lindahl H Malchau H Herberts P | 2005 | J Arthroplasty2005，20，7： | 1 |
| 8 | Characterization of Microbial Community in Granular Sludge Treating Brewery Wastewater 显示文摘 | Liu W T Chanc O C Herbert H P | 2002 | Water Res2002，，36： | 1 |
| 9 | Emergence and properties of spice and bath salts:A medicinal chemistry perspective显示文摘 | Anita H L Herbert H S Carroll F I | 2014 | Life Sci2014，97，1： | 1 |
| 10 | The Swedish Total Hip Replacement Register显示文摘 | Malchau H Herberts P Eisler T | | 0，，2： | 1 |
| 11 | The isolation from wheat germ oil of an alcohol,alpha-tocopherol,having the properties of vitamin E nutrition显示文摘 | Herbert M E Oliver H E Gladys A E | 1936 | The Journal of Biological Chemistry1936，113，： | 1 |
| 12 | Secondary instability of plane channel flow to subharmonic three-dimensional disturbances显示文摘 | Herbert T h | 1983 | Physics of Fluids1983，26，4： | 1 |
| 13 | Loss of interferon regulatory factor 3 in cells infected with classical swine fever virus involves the N-terminal prote- ase, Nvr' 显示文摘 | LA ROCCA S A HERBERT R J CROOKE H | 2005 | Journal of Virology2005，79，11： | 1 |
| 14 | Scaphoid fractures: diagnosis, classification and therapy 显示文摘 | Krimmer H Schmitt R Herbert T | 2000 | Unfallchirurg2000，103，： | 1 |
| 15 | Differential response of soybean yield components to the timing of light enrichment 显示文摘 | Mathew J P Herbert S J Zhang S H | 2000 | Agronomy Journal2000，92，： | 1 |
| 16 | The geochemistry of brines and minerals from the Asse Salt Mine, Germany显示文摘 | NISHRI A HERBERT H J JOCKWER N | 1988 | Applied Geochemistry1988，3，3： | 1 |
| 17 | Acute low back pain: systematic review of its prognosis 显示文摘 | Pengel L H Herbert R D Maher C G | 2003 | BMJ2003，327，7410： | 1 |
| 18 | Fermentation of hexose and pentose sugars using a novel ethanologenic Escherichia coli strain显示文摘 | Robert B H Herbert A W Rodney J B | 1998 | Enzyme and Microbial Technology1998，23，： | 1 |
| 19 | Disparate effects of telomere attrition on gene expression during replicative of human mammary epithelial cells cultured under different conditions 显示文摘 | Zhang H Herbert B S Pan K H | 2004 | Oncogene2004，23，37： | 1 |
| 20 | Differential response of soybean yield components to the timingof light enrichment显示文摘 | Mathew J P Herbert S J Zhang S H | 2000 | Agrono- my Journal2000，92，： | 1 |
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