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| 1 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 2 | Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology显示文摘Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible individuals.Exogenous glucocorticoids(GCs)are widely used as anti-inflammatory therapy in IBDs.In the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of remission.However,this treatment often results in detrimental side effects.This downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery methods.Recent clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse effects.The remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to treatment.In this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with IBDs.This thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study. | Karen Dubois-Camacho Payton A Ottum Daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-Jiménez Mauricio Olivares-Morales Gonzalo Astudillo Rodrigo Quera Marcela A Hermoso | 2017 | World Journal of Gastroenterology2017，23，36： | 6 |
| 3 | Taking aim on bacterial pathogens: from phage therapy to enzybioties 显示文摘 | Hermoso J A Garm'a J L Garm'a P | 2007 | Curr Opin Microbiol2007，10，： | 1 |
| 4 | Gas and aqueous phase formic and acetic acids at a tropical cloud forest site 显示文摘 | Sanhueza E Santana M Hermoso M | 1992 | Atmospheric Environment1992，26，： | 1 |
| 5 | ClC-3 is a fundamental molecular component of volume-sensitive outwardly rectifying Cl^- channels and volume regulation in HeLa cells and Xenopus laevis oocytes显示文摘 | Hermoso M Satterwhite CM Andrade YN | 2002 | J Biol Chem2002，277，40： | 1 |
| 6 | ArchDB:automated protein loop classification as a tool for structural genomics 显示文摘 | JORDI ESPADALER NARCIS FERNANDEZ-FUNENTES ANTONIO HERMOSO | 2004 | Nucleic Acids Research2004，32，： | 1 |
| 7 | ClC-3 is a fundamental molecular component of volume-sensitive outwardly rectifying Cl-channel and volume regulation in HeLa ceils and Xenopus laevis oocytes显示文摘 | Hermoso M Satterwhite CM Andrade Y | 2002 | J Biol Chem2002，205，： | 1 |
| 8 | Electric field measurements at ground level as a basis for lightning hazard warning显示文摘 | MONTANYA J BERGAS J and HERMOSO B | 2004 | Journal of Electrostatics2004，60，： | 1 |
| 9 | Crystal structures of methionine adenosyhransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism显示文摘 | Gonz(alez B Pajares MA Hermoso JA | 2003 | J Mol Biol2003，331，2： | 1 |
| 10 | Penicillin‐binding protein 2a of methicillin‐resistant Staphylococcus aureus显示文摘 | Jennifer Fishovitz Juan A. Hermoso Mayland Chang Shahriar Mobashery | 2014 | IUBMB Life2014，，： | 1 |
| 11 | Electric Field Measurements at Ground Level as a Basis for Lightning Hazard Warning显示文摘 | Montanya J Bergas J Hermoso B | 2004 | Journal of Electristatics2004，60，： | 1 |
| 12 | How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function显示文摘 | Lisandro H. Otero Alzoray Rojas-Altuve Leticia I. Llarrull Cesar Carrasco-López Malika Kumarasiri Elena Lastochkin Jennifer Fishovitz Matthew Dawley Dusan Hesek Mijoon Lee Jarrod W. Johnson Jed F. Fisher Mayland Chang Shahriar Mobashery Juan A. Hermoso | 2013 | Proceedings of the National Academy of Sciences2013，，： | 1 |
| 13 | Lipid nanosystems enhance the bioavailability and the therapeutic efficacy of FTY720 in acute myeloid leukemia 显示文摘 | EstellaHermoso de Mendoza A CastelloCros R Imbuluzqueta E | 2015 | J Biomed Nanotechnol2015，11，4： | 1 |
| 14 | Antileishmanial Activities of Dihydrochalcones from Piper elongatum and Synthetic Related Compounds,Structural Requirements for Activity显示文摘 | HERMOSO A JIMENEZ I A MAMANI Z A | 2003 | Bioorganic & Medicinal Chemistry2003，，11： | 1 |
| 15 | Electric field measurements at ground level as a basis for light- ning hazard warning显示文摘 | MONTANYA J BERGAS J HERMOSO B | 2004 | Journal of Electrostatics2004，60，2： | 1 |
| 16 | A novel nucleopmtein com- plex at a replication origin 显示文摘 | Serrano M Salas M Hermoso JM | 1990 | Science1990，248，4958： | 1 |
| 17 | Rapid and easy method to extract and preserve DNA from Cryptococcus neoformans and other pathogenic yeasts显示文摘 | Sansinforiano ME Padilla JA Hermoso M J | 1998 | Mycoses1998，41，56： | 1 |
| 18 | Congenital lobar hyperinflation:conservative management as an alternative therapy显示文摘 | Hermoso Torreqrosa C Moreno Medinilla E Pérez Ruiz E | | 0，，： | 1 |
| 19 | Functional inhibition of native volume-sensitive outwardly rectifying anion channels in muscle cells and Xenopus oocytes by anti-CIC-3 antibody 显示文摘 | Duan D Zhong J Hermoso M | 2001 | J Physiol2001，531，2： | 1 |
| 20 | Changes in calcium -dependent membrane permeability properties in mitochondria of livers from arthritic rats显示文摘 | Silva PM Tanabe E Hermoso AP | 2008 | Cell Biochem Funct2008，26，4： | 1 |
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