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| 1 | Inflammation, oxidative stress and renin angiotensin system in atherosclerosis显示文摘Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome. The impairment of the endothelium associated with cardiovascular risk factors creates an imbalance between vasodilating and vasoconstricting factors, in particular, an increase in angiotensin Ⅱ(Ang Ⅱ) and a decrease in nitric oxide. The renin-angiotensin system(RAS), and its primary mediator Ang Ⅱ, also have a direct influence on the progression of the atherosclerotic process via effects on endothelial function, inflammation, fibrinolytic balance, and plaque stability. Anti-inflammatory agents [statins, secretory phospholipase A2 inhibitor, lipoprotein-associated phospholipase A2 inhibitor, 5-lipoxygenase activating protein, chemokine motif ligand-2, C-C chemokine motif receptor 2 pathway inhibitors, methotrexate, IL-1 pathway inhibitor and RAS inhibitors(angiotensin-converting enzyme inhibitors)], Ang Ⅱ receptor blockers and ranin inhibitors may slow inflammatory processes and disease progression. Several studies in human using anti-inflammatory agents and RAS inhibitors revealed vascular benefits and reduced progression of coronary atherosclerosis in patients with stable angina pectoris; decreased vascular inflammatory markers, improved common carotid intima-media thickness and plaque volume in patients with diagnosed atherosclerosis. Recent preclinical studies have demonstrated therapeutic efficacy of vitamin D analogs paricalcitol in Apo E-deficient atherosclerotic mice. | Kazim Husain Wilfredo Hernandez Rais A Ansari Leon Ferder | 2015 | World Journal of Biological Chemistry2015，6，3： | 84 |
| 2 | 7核苷酸切除修复交叉互补集团1蛋白表达预测晚期头颈癌患者对诱导化疗的客观应答及生存率显示文摘该文旨在评价核苷酸切除修复交叉互补集团1(ERCC1)的表达与基于铂类诱导化疗的晚期头颈癌患者癌症生存专率的关系。对1992—1996年间的107例行诱导化疗的晚期头颈鳞癌患者进行研究.其中96例存在活检样本。对组织切片行ERCC1蛋白免疫组化染色,双盲法评价蛋白的表达。结果,68例(71%)存在ERCC1蛋白强阳性表达,28例(29%)为低表达。Logistic回归分析显示.蛋白低表达者对化疗的敏感性较高表达者高4倍(P=0.01)。 | Handra-Luca A Hernandez J Mountzios G | 2007 | 中国口腔颌面外科杂志2007，5，5： | 13 |
| 3 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 4 | Biliary cystadenoma显示文摘The diagnosis of cystadenoma is rare, even more so when located in the extrahepatic bile duct.Unspeciflc clinical signs may lead this pathology to be misdiagnosed.The need for pathological anatomy in order to distinguish cystadenomas from simple biliary cysts is crucial.The most usual treatment nowadays is resection of the bile duct, together with cholecystectomy and Roux-en-Y reconstruction. | Miguel A Hernandez Bartolome Sagrario Fuerte Ruiz Israel Manzanedo Romero Beatriz Ramos Lojo Ignacio Rodriguez Prieto Luis Gimenez Alvira Rosario Granados Carreo Manuel Limones Esteban | 2009 | World Journal of Gastroenterology2009，15，28： | 4 |
| 5 | An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair显示文摘The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral repair.Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits.Thus,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the defects.Although both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage.In conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis. | Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 6 | Toxicity of Benzotriazole and Benzotriazole Derivatives to Three Aquatic Species显示文摘 | David A Pillard Jeffrey S Cornell Doree L DuFresne Mark T Hernandez | 2000 | Water Research2000，，2： | 2 |
| 7 | Resistance to Corrosion of galvanized steel covered with an epoxy-poly-amideprimer coating 显示文摘 | Gonzalez S Gil M A Hernandez J O | 2001 | ProgressinOrganicCoatings2001，41，： | 1 |
| 8 | Videothoracoscopic extrapleural insertion of Walter Lorenz Surgical bar for pectus excavatum 显示文摘 | Hernandez H Varela A Cordoba M | 2003 | J Thorac Cardiovasc Surg2003，126，6： | 1 |
| 9 | Echocardiographic evaluation of the Jarvik 2000 axial-flow LVAD显示文摘 | Croitoru M Hernandez A | 2005 | Tex Heart Inst J2005，32，3： | 1 |
| 10 | Risk of uncomplicated peptic ulcer among users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs 显示文摘 | Garcia Rodriguez L A Hernandez Diaz S | 2004 | Am J Epidemiol2004，159，1： | 1 |
| 11 | Adaptive Sampling for Network Management显示文摘 | Edwin A Hernandez Mathew C Chidester Alan D George | 2001 | JNSM2001，9，4： | 1 |
| 12 | CK20 and CK7 protein expression in colorectal cancer: demonstration of the utility of a population-based tissue microarray显示文摘 | HERNANDEZ B Y FRIERSON H F MOSKALUK C A | 2005 | Hum Pathol2005，36，3： | 1 |
| 13 | Ultrasound-assisted Method for the Determination of Chemical Oxygen Demand显示文摘 | CANALS A HERNANDEZ M D R | 2002 | Analytical and Bioanalytical Chemistry2002，374，6： | 1 |
| 14 | Altera- tions of fibfinolysis in stroke显示文摘 | Hernandez Nunez A Romero Barbero JL Caceres Sansaloni A | 1996 | An Med Intena1996，13，3： | 1 |
| 15 | Effect of plant cover decline on chemical and microbiological parameters under Mediterranean climate 显示文摘 | Garcia C Hernandez T Roldan A | 2000 | Soil Biology and Biochemistry2000，34，： | 1 |
| 16 | Studies on the biofiltration capacity of Gracilariopsis longissima : From microscale to macroscale显示文摘 | Hernandez I Perez-Pastor A Vergara J J | 2006 | Aquaculture2006，252，： | 1 |
| 17 | Diagnosis and treatment of submucous cleft palate: A review of 108 cases显示文摘 | Garcia-Velasco M Ysunza A Hernandez X | 1988 | Cleft Palate J1988，25，： | 1 |
| 18 | A review on PEM voltage degradation associated with water management: Impacts, influent factors and characterization 显示文摘 | YOUSFI-STEINER N MOCOTEGUY P CANDUSSO D HISSEL D HERNANDEZ A ASLANIDES A | 2008 | Journal of Power Sources2008，183，1： | 1 |
| 19 | Differential response ofantioxidatlve enzymes of chloroplast and mitochondria to long-term NaClstress of pea plants显示文摘 | Gomez J M Hernandez J A Jimenez A | 1999 | Free Radical Res1999，31，： | 1 |
| 20 | The effect of sample size and species characteristics on performance of different species distribution modeling methods 显示文摘 | Hernandez P A Graham C H Master L L | 2006 | Ecography2006，29，5： | 1 |
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