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| 1 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 2 | High-resolution multimodal flexible coherent Raman endoscope显示文摘Coherent Raman scattering microscopy is a fast,label-free,and chemically specific imaging technique that shows high potential for future in vivo optical histology.However,the imaging depth in tissues is limited to the sub-millimeter range because of absorption and scattering.Realization of coherent Raman imaging using a fiber endoscope system is a crucial step towards imaging deep inside living tissues and providing information that is inaccessible with current microscopy tools.Until now,the development of coherent Raman endoscopy has been hampered by several issues,mainly related to the fiber delivery of the excitation pulses and signal collection.Here,we present a flexible,compact,coherent Raman,and multimodal nonlinear endoscope(4.2mm outer diameter,71mm rigid length)based on a resonantly scanned hollow-core Kagomé-lattice double-clad fiber.The fiber design enables distortion-less,background-free delivery of femtosecond excitation pulses and back-collection of nonlinear signals through the same fiber.Sub-micrometer spatial resolution over a large field of view is obtained by combination of a miniature objective lens with a silica microsphere lens inserted into the fiber core.We demonstrate high-resolution,high-contrast coherent anti-Stokes Raman scattering,and second harmonic generation endoscopic imaging of biological tissues over a field of view of 320μm at a rate of 0.8 frames per second.These results pave the way for intraoperative label-free imaging applied to real-time histopathology diagnosis and surgery guidance. | Alberto Lombardini Vasyl Mytskaniuk Siddharth Sivankutty Esben Ravn Andresen Xueqin Chen Jérôme Wenger Marc Fabert Nicolas Joly Frédéric Louradour Alexandre Kudlinski Hervé Rigneault | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 3 | Performance of PIVKA-II for early hepatocellular carcinoma diagnosis and prediction of microvascular invasion显示文摘 | Nicolas Poté Fran?ois Cauchy Miguel Albuquerque Hélène Voitot Jacques Belghiti Laurent Castera Hervé Puy Pierre Bedossa Valérie Paradis | 2014 | Journal of Hepatology2014，，： | 2 |
| 4 | DRB4-Dependent TAS3 trans -Acting siRNAs Control Leaf Morphology through AGO7显示文摘 | Xavier Adenot Taline Elmayan Dominique Lauressergues Stéphanie Boutet Nicolas Bouché Virginie Gasciolli Hervé Vaucheret | 2006 | Current Biology2006，，9： | 1 |
| 5 | Isolation and characterization of highly polymorphic microsatellite loci in the bladder campion,Silene vulgaris (Caryophyllaceae)显示文摘 | Nicolas Juillet HerV Freymond Loic Degen | 2003 | Molecular Ecology Notes2003，3，： | 1 |
| 6 | Characterization of an Antigen That Is Recognized on a Melanoma Showing Partial HLA Loss by CTL Expressing an NK Inhibitory Receptor显示文摘 | Hideyuki Ikeda Bernard Lethé Frédéric Lehmann Nicolas Van Baren Jean-Fran?ois Baurain Charles De Smet Hervé Chambost Massimo Vitale Alessandro Moretta Thierry Boon Pierre G Coulie | 1997 | Immunity1997，，2： | 1 |
| 7 | Characterisation of activated sludge by automated image analysis显示文摘 | Mauricio da Motta Marie-Noёlle Pons Nicolas Roch Hervé Vivier | 2001 | Biochemical Engineering Journal2001，9，3： | 1 |
| 8 | Relation between shear banding and penetration characteristics of conventional tungsten alloys 显示文摘 | COUQUE Herve NICOLAS Guy ALTMAYER Claude | 2007 | International Journal of Impact Engineering2007，34，3： | 1 |
| 9 | Expression ofGFRal receptor splicing variants with differen tbiochemicalpropertiesis modulated during kidney development显示文摘 | Nicolas C B Herve L H Mariaiosaria I | 2004 | Cellu-lar Signalling2004，16，12： | 1 |
| 10 | Neoadjuvant targeted molecular therapies in patients undergoing nephrectomy and inferior vena cava thrombectomy: is it useful?显示文摘 | Pierre Bigot Tarek Fardoun Jean Christophe Bernhard Evanguelos Xylinas Julien Berger Morgan Rouprêt Jean-Baptiste Beauval Samuel Lagabrielle Souhil Lebdai Myriam Ammi Hervé Baumert Bernard Escudier Nicolas Grenier Jean-Fran?ois Hétet Jean-Alexandre Long P | 2014 | World Journal of Urology2014，，： | 1 |
| 11 | Local and interactive post-buckling of RHS thin-walled members-Comparing a new special beam finite element with shell FE models 显示文摘 | Degee Herve Boissonnade Nicolas Rossi Barbara | 2007 | International Journal of Structural Stability and Dynamics2007，7，2： | 1 |
| 12 | N--3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE,ECE): in vitro and in vivo activities显示文摘 | Nicolas I Hervé P Franck T | 2002 | Bioorg Med Chem Lett2002，12，15： | 1 |
| 13 | Dose-dense rituximab-CHOP compared with standard rituximab-CHOP in elderly patients with diffuse large B-cell lymphoma (the LNH03-6B study): a randomised phase 3 trial显示文摘 | Richard Delarue Hervé Tilly Nicolas Mounier Tony Petrella Gilles Salles Catherine Thieblemont Serge Bologna Hervé Ghesquières Maya Hacini Christophe Fruchart Lo?c Ysebaert Christophe Fermé Olivier Casasnovas Achiel Van Hoof Antoine Thyss Alain Delmer Oliv | 2013 | Lancet Oncology2013，，： | 1 |
| 14 | Detecting salinity hazards within a semiarid context by means of combining soil and remote-sensing data显示文摘 | Abd E1 Kader Douaoui Herve Nicolas Christian Waiter | 2006 | Geoderma2006，134，： | 1 |
| 15 | Detecting salinity hazards within a semiarid context by means of combining soil and remote-sensing data显示文摘 | Abd E1 Kader Douaoui Herve Nicolas Christian Waiter | 2006 | Geoderma2006，134，12： | 1 |
| 16 | N-amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE,ECE):In vitro and in vivo activities 显示文摘 | Nicolas I Herve P Franck T | 2002 | Bioorg Med Chem Lett2002，12，： | 1 |
| 17 | Extension of the super-elements method to the analysis of oblique collision between two ships显示文摘 | Loic Buldgen HervéLe Sourne Nicolas Besnard | 2012 | Marine Structures2012，29，： | 1 |
| 18 | Erratum to: Early postoperative prophylactic noninvasive ventilation after major lung resection in COPD patients: a randomized controlled trial显示文摘 | Christine Lorut Aurélie Lefebvre Benjamin Planquette Laurent Quinquis Hervé Clavier Nicola Santelmo Halim Abou Hanna Fran?ois Bellenot Jean-Fran?ois Regnard Marc Riquet Pierre Magdeleinat Guy Meyer Nicolas Roche Marie-Pierre Revel Gérard Huchon Joel Coste | 2014 | Intensive Care Medicine2014，，3： | 1 |
| 19 | An antagonistic function for Arabidopsis DCL2 in development and a new function for DCL4 in generating viral siRNAs显示文摘 | Nicolas Bouche' Dominique Lauressergues Virginie Gasciolli Herve' Vaucheret | | 0，，： | 1 |
| 20 | Impact of nanocrystallinity segregation on the growth and morphology of nanocrystal superlattices显示文摘5 nm Au tetradecanethiol 涂的 nanoparticles 的一个胶体的答案被综合。在一落下的快蒸发以后,订了两个都由单个领域组成的单层,多晶的 nanocrystals 被获得。在增加材料和蒸发时间的数量以后,有不规则的轮廓的 nanocrystal 电影和展出截断有四面的形状的拥挤不堪的 3D 超点阵被生产。用散布光谱学和电子显微镜学的低频率的 micro-Raman,积木 nanocrystallinity 被描绘。自发的 nanocrystallinity 分离被揭示:当 supracrystalline 电影由单个领域和多晶的 nanocrystals 的混合物组成时,截断有四面的 supracrystals 被显示主要包含单个领域积木。这观察指出在涉及 nanocrystal 超点阵和他们的形态学的生长的 nanocrystallinity 分离之间的关联。 | Yanfen Wan Herve Portals Nicolas Goubet Alain Mermet Marie-Paule Pileni | 2013 | Nano Research2013，6，8： | 0 |
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