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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction显示文摘AIM: To characterise the effect of energy restriction (ER) on liver lipid and primary metabolite profile by using metabolomic approach. We also investigated whether the effect of energy restriction can be further enhanced by modif ication of dietary protein source and calcium. METHODS: Liver metabolomic profile of lean and obese C57Bl/6J mice (n = 10/group) were compared with two groups of weight-reduced mice. ER was performed on control diet and whey protein-based high-calcium diet (whey + Ca). The metabolomicanalyses were performed using the UPLC/MS based lipidomic platform and the HPLC/MS/MS based primary metabolite platform. RESULTS: ER on both diets significantly reduced hepatic lipid accumulation and lipid droplet size, while only whey + Ca diet significantly decreased blood glucose (P < 0.001) and serum insulin (P < 0.01). In hepatic lipid species the biggest reduction was in the level of triacylglycerols and ceramides while the level of cholesterol esters was significantly increased during ER. Interestingly, diacylglycerol to phospholipid ratio, an indicator of relative amount of diabetogenic diglyceride species, was increased in the control ER group, but decreased in the whey + Ca ER group (P < 0.001, vs obese). ER on whey + Ca diet also totally reversed the obesity induced increase in the relative level of lipotoxic ceramides (P < 0.001, vs obese; P > 0.05, vs lean). These changes were accompanied with up-regulated TCA cycle and pentose phosphate pathway metabolites. CONCLUSION: ER-induced changes on hepatic metabolomic profile can be significantly affected by dietary protein source. The therapeutic potential of whey protein and calcium should be further studied. | Taru K Pilvi Tuulikki Seppnen-Laakso Helena Simolin Piet Finckenberg Anne Huotari Karl-Heinz Herzig Riitta Korpela Matej Orei Eero M Mervaala | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 3 | Selective inhibitors of vitamin D metabolism--new concepts and perspectives显示文摘 | Schuster I Egger H Herzig G | 2006 | Anticancer Res2006，26，4： | 1 |
| 4 | Acid-suppressive medication use and the risk for hospital-acquired pneumonia显示文摘 | Herzig S J Howell M D Ngo I H | | 0，，09： | 1 |
| 5 | Physical and chemical processes of seafloor mineralization at mid-oceanridges显示文摘 | Hannington M D Jonasson I R Herzig P M | 1995 | Geophysical Monograph Series1995，91，： | 1 |
| 6 | Physical and chemical processes of seafloor mineralization at mid-ocean ridge:American Geophysical Union 显示文摘 | Hannington M D Jonasson I R Herzig P M | 1995 | C eophsieal Monograph1995，91，： | 1 |
| 7 | Occurrence of diabetes mellitus in spontaneous intracerebral hernorrhage显示文摘 | Herzig R Vlachova I Mares J | 2007 | Acta Di- abetol2007，44，4： | 1 |
| 8 | Improved spreading rates for monolayers applied as emulsions to reduce water evaporation显示文摘 | Herzig M A Barnes G T Gentle I R | 2011 | Journal of Colloid and Interface Sci- ence2011，357，1： | 1 |
| 9 | Selenium content in the blood serum and urine of ewes receiving seleniumenriched unicellular alga Chlorella显示文摘 | Trávni(c)ek J Písek L Herzig I | 2007 | Vet Med2007，52，： | 1 |
| 10 | Occurrence of diabetes mellitus in spontaneous intracerebral hemorrhage显示文摘 | Herzig R Vlachová I Mares J | 2007 | Acta Diabetol2007，44，4： | 1 |
| 11 | Carbadox in combination with furazolidone in the prevention of enteral and growth disorders in weaned piglets显示文摘 | Vorak M Herzig I | 1978 | Vet Med(Prague)1978，23，2： | 1 |
| 12 | Vet Med显示文摘 | Herzig I Hamp L J Docekalova H | 1994 | 39 : 1751994，39，： | 1 |
| 13 | CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma显示文摘 | HERZIG S HEDRICK S MORANTTE I | 2003 | Nature2003，426，6963： | 1 |
| 14 | Comparison of ul trasonography,CT angiography, and digital subtraction angiography in severe carotid stenoses显示文摘 | Herzig R Burval S Vlachova I | 2004 | European Journa 1 of Neurology2004，11，11： | 1 |
| 15 | CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma显示文摘 | HEDRICK S MORANTTE I | 2003 | Nature2003，426，6963： | 1 |
| 16 | Toxicotogical risk of melamine and cyanuric acid in food and feed显示文摘 | SUCHY P STRAKOVA E HERZIG I | 2009 | Interdisc Toxicology2009，2，2： | 1 |
| 17 | Selenium content in blood serum and urine of ewes receiving selenium enriched unicellular alga Chlorella显示文摘 | Trávníˇcek J Písek L Herzig I | 2007 | Vet Med2007，，52： | 1 |
| 18 | The effect of sodium huminate on cadmium deposition in the organs of chickens 显示文摘 | Herzig I Hampl J Docekalova H | 1994 | Vet Med1994，39，： | 1 |
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