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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Dynamic Stability Analysis of Linear Time-varying Systems via an Extended Modal Identification Approach显示文摘The problem of linear time-varying(LTV) system modal analysis is considered based on time-dependent state space representations, as classical modal analysis of linear time-invariant systems and current LTV system modal analysis under the ‘‘frozen-time'' assumption are not able to determine the dynamic stability of LTV systems.Time-dependent state space representations of LTV systems are first introduced, and the corresponding modal analysis theories are subsequently presented via a stabilitypreserving state transformation. The time-varying modes of LTV systems are extended in terms of uniqueness, and are further interpreted to determine the system's stability. An extended modal identification is proposed to estimate the time-varying modes, consisting of the estimation of the state transition matrix via a subspace-based method and the extraction of the time-varying modes by the QR decomposition. The proposed approach is numerically validated by three numerical cases, and is experimentally validated by a coupled moving-mass simply supported beam experimental case. The proposed approach is capable of accurately estimating the time-varying modes, and provides a new way to determine the dynamic stability of LTV systems by using the estimated time-varying modes. | Zhisai MA Li LIU Sida ZHOU Frank NAETS Ward HEYLEN Wim DESMET | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 2 |
| 3 | A new approach for fuel injection into a solar receiver/ reactor:Numerical and experimental investigation显示文摘An innovative and efficient design of solar receivers/reactors can enhance the production of clean fuels via concentrated solar energy.This study presents a new jet-type burner nozzle for gaseous feedstock injection into a cavity solar receiver inspired from the combustion technology.The nozzle design was adapted from a combustion burner and successfully implemented into a solar receiver and studied the influence of the nozzle design on the fluid mixing and temperature distribution inside the solar receiver using a 7 kW solar simulator and nitrogen as working fluid.Finally,a thorough computational fluid dynamics (CFD) analysis was performed and validated against the experimental results.The CFD results showed a variation of the gas flow pattern and gas mixing after the burner nozzle adaptation,which resulted an intense effect on the heat transfer inside the solar receiver. | M Helal Uddin Nesrin Ozalp Jens Heylen Cedric Ophoff | 2018 | Frontiers of Chemical Science and Engineering2018，12，4： | 2 |
| 4 | L’alimentation entérale précoce du traumatisé cranien显示文摘 | C De Deyne R De Jongh L Merckx J Deghislage R Heylen | 1998 | Annales francaises d’anesthesie et de reanimation1998，，2： | 2 |
| 5 | Parametric modal identification of time-varying structures and the validation approach of modal parameters显示文摘 | Zhou S D Heylen W Sas P | 2014 | Mechanical Systems and Signal Processing2014，47，1： | 1 |
| 6 | Modal Analysis Theory and Testing显示文摘 | Ward Heylen Stefan Lammens Paul Sas | 1997 | Katholieke universiteit Leaven1997，，2： | 1 |
| 7 | Worm proteins of schistosoma mansoni reduce the severity of experimental chro- nic colitis in mice by suppressing colonic proinflammatory im- mune responses显示文摘 | Heylen M Ruyssers NE De Man JG | 2014 | PLoS One2014，9，10： | 1 |
| 8 | Maximum likelihood estimator of operational modal analysis for linear time-varying structures in time-frequency domain显示文摘 | Zhou S D Heylen W Sas P | 2014 | Journal of Sound and Vibration2014，333，11： | 1 |
| 9 | Evaluation of function- al and mental state and quality of life in chronic hemodialysis pa- tients显示文摘 | Janssen van DK Heylen M Mets T etal | 2004 | Int Urol Nephrol2004，36，： | 1 |
| 10 | Characterization of human rotaviruses circulating in Iraq in 2008: Atypical G8 and high prevalence of P[6] strains显示文摘 | Salwa Ahmed John Klena Antun Albana Faisal Alhamdani John Oskoff Mireille Soliman Elisabeth Heylen Nadia Teleb Tupur Husain Jelle Matthijnssens | 2013 | Infection, Genetics and Evolution2013，，： | 1 |
| 11 | Pilot clinical investigation of risperidone in the treatment of psychotic patients显示文摘 | Heylen SL Vanden Bussche | 1990 | Pharmacopsychiary1990，23，5： | 1 |
| 12 | Comparison ofinduction machine stator vibration spectra induced byreluctance forces and magnetostriction显示文摘 | Delaere K Heylen W Belmans R | 2002 | IEEE Trans onMagnetics2002，38，3： | 1 |
| 13 | The indicies of nirS andnirK and their genetic heterogeneity in cultivated denitrifiers显示文摘 | Heylen K Gevers D Vanparys B | 2006 | Environmental Microbiology2006，8，： | 1 |
| 14 | Non-linear spectral unmix- ing by geodesic simplex volume maximization显示文摘 | Heylen R Burazerovic D Scheunders P | 2011 | IEEE Journal of Selected Topics in Signal Processing2011，5，3： | 1 |
| 15 | Nitric oxide reductase(norB) gene sequence analysis reveals discrepancies with nitritereductase (nir) gene phylogeny in cultivated denitrifiers显示文摘 | Heylen K Vanparys B Gevers D | 2007 | Environmental Microbiology2007，9，： | 1 |
| 16 | Comparison of induction machine stator vibration spectra induced by reluctance forces and magnetostriction 显示文摘 | Delaere K Heylen W Belmans R Hameyer K | 2002 | IEEE Transactions on Magnetics2002，38，3： | 1 |
| 17 | Comparison of induction machine stator vibration spectra induced by reluctance forces and magnetostriction显示文摘 | Delaere K Heylen W Belmans R | 2002 | IEEE Transactions on Magnetics2002，38，2： | 1 |
| 18 | Rotavirus surveillance in kisangani, the democratic republic of the congo, reveals a high number of unusual genotypes and gene segments of animal origin in non-vaccinated symptomatic children显示文摘 | Heylen E Batoko Likele B Zeller M | 2014 | PLoS One2014，9，10： | 1 |
| 19 | Fully constrained least squares spectral unmixing by simplex projection显示文摘 | Heylen R Burazerovic D and Scheunders P | 2011 | IEEE Transactions on Geoscience and Remote Sensing2011，49，11： | 1 |
| 20 | Public capital and productivity growth : evidence for Belgium, 1953 - 1996 显示文摘 | EVERAERT G HEYLEN F | 2001 | Economic Modeling2001，18，1： | 1 |
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