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| 1 | Prognosis following transcatheter arterial embolization for 121 patients with unresectable hepatocellular carcinoma with or without a history of treatment显示文摘瞄准:回顾地为 HCC 后面的 transcatheter 与肝细胞癌(HCC ) 评估病人的预后与或没有治疗的历史动脉的 embolization (TAE ) 。方法:有在我们的医院里从 1992 ~ 2004 与 TAE 对待的 HCC 的 121 个病人在这研究被注册。84 个病人为 HCC 有治疗的历史,当时 37。在入口,有额外肝的转移的病人,门静脉肿瘤血栓,或孩子呸班的时候, C 被排除。当 HCC 的复发被提高的肿瘤标记,或 ultrasonography 或动态计算断层摄影术调查结果诊断时, TAE 被重复。结果:肿瘤尺寸更大,没有过去的治疗(P<0.01 ) ,肿瘤的数字是在病人的少数。然而,在节点转移(TNM ) 舞台或幸存在 2 个组之间评估的肿瘤没有差别。一个双性人 alpha-fetoprotein (法新社)(>100 ng/mL ) 的小叶片的肿瘤和高水平是与在有 HCC 的历史的病人的差的预后有关的因素。结论:预后追随者 TAE 在有或没有过去的治疗的 HCC 病人之间是类似的。在到一堂重复 TAE 功课的入口能改进预后以前, HCC 或周期性的 HCC 和获得的好本地人的早诊断对 HCC 控制。 | Atsushi Hiraoka Teru Kumagi Masashi Hirooka Takahide Uehara Kiyotaka Kurose Hidehito luchi Yoichi Hiasa Bunzo Matsuura Kojiro Michitaka Seishi Kumano Hiroaki Tanaka Yoshimasa Yamashita Norio Horiike Teruhito Mochizuki Morikazu Onji | 2006 | World Journal of Gastroenterology2006，12，13： | 9 |
| 2 | Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development显示文摘AIM: To investigate risk factors for development of hepatocellular carcinoma(HCC) in patients with hepatitis C virus-related liver cirrhosis(LC-C).METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon(IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance imaging.RESULTS: HCC was diagnosis in 50(21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older(P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein(AFP)(P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P < 0.001, odds ratio(OR) = 15.27, 95%CI: 4.98-59.51], AFP levels of ≥ 10 ng/m L(P = 0.009, OR = 3.89, 95%CI: 1.38-11.94), and des-γ-carboxy prothrombin(DCP) levels of ≥ 40 m AU/mL at 24 wk after the completion of IFN and ribavirin therapy(P < 0.001, OR = 24.43, 95%CI: 4.11-238.67).CONCLUSION: We suggested that the elevation of AFP and DCP levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients. | Satoshi Shakado Shotaro Sakisaka Kazuaki Chayama Takeshi Okanoue Joji Toyoda Namiki Izumi Akihiro Matsumoto Tetsuo Takehara Akio Ido Yoichi Hiasa Kentaro Yoshioka Hideyuki Nomura Yoshiyuki Ueno Masataka Seike Hiromitsu Kumada | 2015 | World Journal of Hepatology2015，7，27： | 3 |
| 3 | Recurrence of autoimmune hepatitis after liver transplantation without elevation of alanine aminotransferase显示文摘It is controversial whether steroid therapy should be continued to prevent the recurrence of autoimmune hepatitis(AIH)in patients who have undergone liver transplantation(LTx)due to AIH.We report a case of recurrent autoimmune hepatitis after LTx despite a persistently normal range of alanine aminotransferase(ALT).A 50-year-old woman was admitted to our hospital because of jaundice and severe liver dysfunction,where she was diagnosed with liver failure due to AIH.Steroid therapy was not effective enough and the patient received living-donor LTx in 1999.Following the operation,the level of ALT was maintained within a normal range and anti-nuclear antibody(ANA)became negative,however,the serum level of IgG gradually elevated and ANA became positive,while platelets decreased.A liver biopsy performed 6 years after LTx showed histological findings of AIH and she was diagnosed with recurrent AIH.A recurrence of AIH may occur after LTx even if the level of ALT remains within a normal range.We consider that a protocol liver biopsy should be performed in patients who undergo LTx due to AIH to decide the indication for steroid therapy. | Huaiqi Yao Kojiro Michitaka Yoshio Tokumoto Yosuke Murata Toshie Mashiba Masanori Abe Yoichi Hiasa Norio Horiike Morikazu Onji | 2007 | World Journal of Gastroenterology2007，13，10： | 3 |
| 4 | Phase I/II study of immunotherapy using tumor antigen-pulsed dendriticcells in patients with hepatocellular carcinoma显示文摘 | Fujimasa Tada Masanori Abe Masashi Hirooka Yoshiou Ikeda Yoichi Hiasa Yoon Lee Nam-Chul Jung Woo-Bok Lee Hyun-Soo Lee Yong-Soo Bae Morikazu Onji | 2012 | International Journal of Oncology2012，，： | 2 |
| 5 | The effects of atorvastatin on coronary endothelial function in patients with recent myocardial infarction 显示文摘 | Hosokawa S Hiasa Y Tomokane T el al | 2006 | Clin Cardiol2006，29，8： | 1 |
| 6 | hnpact of hydroxymethylglutaryl coenzyme A reductase inhibition on left ventricular remodeling in patients with acute anterior myocardial infarction after primary coronary angioplasty显示文摘 | Ohara Y Hiasa Y Hosokawa S | 2005 | Int Heart J2005，46，6： | 1 |
| 7 | Direct solid liquid seperation using hollowfiber membrane in an activated sludge aeration tank显示文摘 | Yamarnoto K Hiasa M Mahmood T | 1989 | Wat Sei Tech1989，，21： | 1 |
| 8 | Gene transfer of stromal cell-derived factor-1:enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway显示文摘 | Hiasa K Ishibashi M Ohtani K | 2004 | Circulation2004，109，20： | 1 |
| 9 | Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin 显示文摘 | Tanaka Y Abe M Hiasa M | 2007 | Clin Cancer Res2007，13，3： | 1 |
| 10 | Essential Role of Vascular Endothelial Growth Factor in Angiotensin Ⅱ-Induced Vascular Inflammation and Remodeling显示文摘 | Ishibashi M Hiasa K | 2004 | Hypertension2004，44，： | 1 |
| 11 | Direct solid-liquid separation using hollow fiber membrane in an activated sludge aeration tank显示文摘 | Yamamoto K Hiasa M Mahmood T | 1989 | Water Science and Technology1989，21，45： | 1 |
| 12 | Aerobic exercise im- proves insulin resistance and decreases body fat and serum lev els of leptin in patients with hepatitis C virus显示文摘 | Konishi I Hiasa Y Tokumoto Y | 2011 | Hepatol Res2011，41，92： | 1 |
| 13 | Effects of smoking cessation on coronary endothelial function in patients with recent myocardial infarction显示文摘 | Hosokawa S Hiasa Y Miyazaki S | 2008 | Int J Cardiol2008，128，1： | 1 |
| 14 | Direct sol- id-liquid separation using hollow fiber membrane in an activated sludge aeration tank 显示文摘 | Yamamoto K Hiasa M Mahmood T | 1989 | Water Sci and Teeh- nol1989，21，： | 1 |
| 15 | Bone marrow mononuclear cell therapy limits myocardial infarct size through vascular endothelial growth factor显示文摘 | HIASA K EGASHIRA K KITAMOTO S | 2004 | Basic Res Cardiol2004，99，： | 1 |
| 16 | Gene transfer of stromal cell-derived factor-1alpha enhances is chemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway:next-generation chemokine therapy for therapeutic neovascularization显示文摘 | Hiasa K Ishibashi M Ohtani K Inoue S Zhao Q Kitamoto S Sata M Ichiki T Takeshita A EgashiraK | 2004 | Circulation2004，109，： | 1 |
| 17 | Monocyte chemoattractant protein-1 is an essential inflammatory mediator in angiotensin Ⅱ-inducd progression of established atherosclerosis in hypercholesterolemic mice显示文摘 | Ni W Kitamoto S Ishibashi M Usui M Inoue S Hiasa K | 2004 | Arterioscler Thromb Vasc Biol2004，24，3： | 1 |
| 18 | Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth显示文摘 | Takeuchi K Abe M Hiasa M | 2010 | PLoS One2010，5，3： | 1 |
| 19 | Myeloma cell-osteo-clast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin显示文摘 | Tanaka Y Abe M Hiasa M | 2007 | Clin Cancer Res2007，13，3： | 1 |
| 20 | Pereutaneous hot saline injection therapy for hepatic tumors: an alternative to pereutaeous ethanol injection therapy显示文摘 | Honda N Guo Q Uehida H Hiasa Y | 1994 | Radiology1994，190，： | 1 |
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