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| 1 | Inhibitory effect of voglibose and gymnemic acid on maltose absorption in vivo显示文摘AIM To determine whether diabetic care can be improved by combination of voglibose and gymnemic acid ( GA ), we compared the combinative and individual effects of voglibose and GA on maltose absorption in small intestine.METHODS The small intestine 30 cm long from 2 cm caudal ward Treitz's ligament of Wistar rat was used as an in situ loop, which was randomly perfused in recircular mode with maltose (10 mmol/L) with or without different dosages of voglibose and/or GA for an hour. To compare the time course, perfusion of 10 mmol/L maltose was repeated four times.Each time continued for 1 hour and separated by 30 minutes rinse. In the first time, lower dosages of GA (0.5g/ L) and/ or voglibose (2μmol/L) were contained except control.RESULTS Absorptive rate of maltose was the lowest in combinative group (P< 0.05, ANOVA),for example, the inhibition rate was about 37%during the first hour when 0.5g/L GA and 2μmol/L voglibose with 10mmol/L maltose were perfused in the loop. The onset time was shortened to 30 minutes and the effective duration was prolonged to 4 hours with the combination; therefore the total amount of maltose absorption during the effective duration was inhibited more significantly than that in the individual administration (P<0.05, U test of Mann-Whitney). The effect of GA on absorptive barriers of the intestine played an important role in the combinative effects.CONCLUSION There are augmented effects of voglibose and GA. The management of diabetes mellitus can be improved by employing the combination. | Toshiaki Imoto Yasutake Hiji | 2001 | World Journal of Gastroenterology2001，7，2： | 3 |
| 2 | Inhibitory effect and mechanism of acarbose combined with gymnemic acid on maltose absorption in rat intestine显示文摘AIM To compare the combinative andindividual effect of acarbose and gymnemic acid(GA) on maltose absorption and hydrolysis insmall intestine to determine whether nutrientcontrol in diabetic care can be improved bycombination of them.METHODS The absorption and hydrolysis ofmaltose were studied by cyclic perfusion ofintestinal loops in situ and motility of theintestine was recorded with the intestinal ring invitro using Wistar rats.RESULTS The total inhibitory rate of maltoseabsorption was improved by the combination ofGA (0.1 g/L 1.0 g/L) and acarbose(0.1 mmol/L 2.0 mmol/L) throughout theireffective duration (P<0.05, U test of Mann-Whitney), although the improvement only couldbe seen at a Iow dosage during the first hour.With the combination, inhibitory duration of acarbose on maltose absorption was prolonged to 3 h and the inhibitory effect onset of GA was fastened to 15min. GA suppressed the intestinal mobility with a good correlation (r-0.98) to the inhibitory effect of GA on maltose absorption and the inhibitory effect of 2mmol/L (high dose) acarbose on maltose hydrolysis was dual modulated by 1 g/L GA in vivo indicating that the combined effects involved the functional alteration of intestinal barriers.CONCLUSION There are augmented effects of acarbose and GA, which involve pre-cellular and paracellular barriers. Diabetic care can be improved by employing the combination. | Toshiaki Imoto Yasutake Hiji | 2001 | World Journal of Gastroenterology2001，7，1： | 2 |
| 3 | Cultual practices for managing Bemisia tabaci and associated viral diseases显示文摘 | LUKO HIJI HEATHER S COSTA H S | 2001 | Crop Protection2001，20，： | 1 |
| 4 | Effects of acarbose combined with Gymnemic acid on maltose digestion and absorption显示文摘 | Imoto Toshiaki Hiji Yasutake | 1998 | Shoka to Kyushu1998，21，2： | 1 |
| 5 | Modeling Manufacturing Resources Based on Agent Model显示文摘 | Masahiro Hiji Masaru Tezuka | | IEEE0，，： | 1 |
| 6 | Effects of a carbose combined with Gymnemic acid on maltose digestion and absorption 显示文摘 | Luo Hong Imoto Toshiaki Hiji Yasutake | 1998 | Shoka to Kyushu1998，21，2： | 1 |
| 7 | White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease:TDP-43-immunopositive inclusions co-localize with p62,but not ubiquitin显示文摘 | Hiji M Takahashi T Fukuba H Yamashita H Kohriyama T Matsumoto M | | 0，，02： | 1 |
| 8 | Relationship between neuronal loss and tangle formation in neurons and oligodendroglia in progressive supranuclear palsy显示文摘 | Jin C Katayama S Hiji M | 2006 | Neuropathology2006，26，： | 1 |
| 9 | Relationship between neuronal loss and tangle formation in neurons and oligo- dendroglia in progressive supra-nuclear palsy显示文摘 | Jin C Katayama S Hiji M et aI | 2006 | Neuropathology2006，26，1： | 1 |
| 10 | Immunopositivity for ES-CRT-Ⅲsubunit CHMP2B in granulovacuolar degeneration ofneurons in the Alzheimer's disease hippocampus显示文摘 | Yamazaki Y Takahashi T Hiji M | 2010 | NeurosciLett2010，477，2： | 1 |
| 11 | The Impact of Resorcinol Bis ( diphenyl phosphate) and Poly ( phenylene ether) on Flame Retardancy of PC/PBT bIends显示文摘 | Shumei Liu Lei Jiang Z hijie Jiang | | Poly- mer Advanced Technology0，22，： | 1 |
| 12 | 2,3-二氯苯基哌嗪合成方法的改进(英文)显示文摘2,3-二氯苯胺硫酸盐经重氮化,再与KI置换生成相应的芳基碘化物,产率81%。芳基碘化物与哌嗪在二甲基亚砜中反应,CuI和脯氨酸为催化剂,收率20%。该方法操作简单,对湿不敏感,产物易于分离,具有一定的实用价值。 | HIJI Morris Frank 郑国钧 袁其朋 | 2007 | 北京化工大学学报(自然科学版)2007，34，4： | 0 |
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