|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | State-of-the-Art management of knee osteoarthritis显示文摘Osteoarthritis(OA) is the most common type of arthritis found in the United States' population and is also the most common disease of joints in adults throughout the world with the knee being the most frequently affected of all joints. As the United States' population ages along with the increasing trends in obesity prevalence in other parts of the world, it is expected that the burden of OA on the population, healthcare system, and overall economy will continue to increase in the future without making major improvements in managing knee OA. Numerous therapies aim to reduce symptoms of knee OA and continued research has helped to further understand the complex pathophysiology of its disease mechanism attempting to uncover new potential targets for the treatment of OA. This review article seeks to evaluate the current practices for managing knee OA and discusses emerging therapies on the horizon. These practices include non-pharmacological treatments such as providing patient education and self-management strategies, advising weight loss, strengthening programs, and addressing biomechanical issues with bracing or foot orthoses. Oral analgesics and anti-inflammatories are pharmacologicals that are commonly used and the literature overall supports that some of these medications can be helpful for managing knee OA in the short-term but are less effective for long-term management. Additionally, more prolonged use significantly increases the risk of serious associated side effects that are not too uncommon. Diseasemodifying osteoarthritis drugs are being researched as a treatment modality to potentially halt or slow disease progression but data at this time is limited and continued studies are being conducted to further investigate their effectiveness. Intra-articular injectables are also implemented to manage knee OA ranging from corticosteroids to hyaluronans to more recently plateletrich plasma and even stem cells while several other injection therapies are presently being studied. The goal of developing new treatment strategies for knee OA is to prolong the need for total knee arthroplasty which should be utilized only if other strategies have failed. High tibial osteotomy and unicompartmental knee arthroplasty are potential alternatives if only a single compartment is involved with more data supporting unicompartmental knee arthroplasty as a good treatment option in this scenario. Arthroscopy has been commonly used for many years to treat knee OA to address degenerative articular cartilage and menisci, however, several high-quality studies have shown that it is not a very effective treatment for the majority of cases and should generally not be considered when managing knee OA. Improving the management of knee OA requires a multi-faceted treatment approach along with continuing to broaden our understanding of this complex disease so that therapeutic advancements can continue to be developed with the goal of preventing further disease progression and even potentially reversing the degenerative process. | Kenton H Fibel Howard J Hillstrom Brian C Halpern | 2015 | World Journal of Clinical Cases2015，3，2： | 19 |
| 2 | Testing Unconstrained Optimization Software显示文摘 | Jorge J. Moré Burton S. Garbow Kenneth E. Hillstrom | 1981 | ACM Transactions on Mathematical Software (TOMS)1981，，1： | 4 |
| 3 | Testing Unconstrained Optimization Software显示文摘 | More J J Garbow B S Hillstrom K E | 1981 | ACM Transactions on Mathematical Software1981，，7： | 1 |
| 4 | Testing unconstrained optimization software显示文摘 | More J J Garbow B S Hillstrome K E | 1981 | ACM Transactions on Mathematical Software1981，，7： | 1 |
| 5 | Tes- ting Unconstrained Optimization Software 显示文摘 | MORE J J GARBOW B S HILLSTROM K E | 1981 | ACM Transactions on Mathematical Software1981，7，1： | 1 |
| 6 | Social network development, language use, and language ac- quisition during study abroad: Arabic language learners' perspectives显示文摘 | Dewey D P Belnap R K Hillstrom R | 2013 | Frontiers: The interdisciplinary journal of study abroad2013，22，： | 1 |
| 7 | Testing unconstrained optimization software显示文摘 | Morè J J Garbow B S Hillstrome K E | 1981 | ACM Trans Math Software1981，7，： | 1 |
| 8 | Testing unconstrainedoptimization software显示文摘 | More J J Garbow B S Hillstrom K H | 1981 | ACM Trans on Math Software1981，7，： | 1 |
| 9 | Knee osteoarthritis:primary care u- sing noninvasive devices and biomechanical principles 显示文摘 | Gross KD Hillstrom H | 2009 | Med Clin2009，93，： | 1 |
| 10 | A review of depression and quality of life outcomes in adolescents post bariatric surgery显示文摘 | Hillstrom KA Graves JK | 2015 | J Child Adolesc Phychiatr Nurs2015，28，： | 1 |
| 11 | The distributed plantar vertical force of neutrally aligned and pes planus feet显示文摘 | Ledoux WR Hillstrom HJ | 2002 | Gait Posture2002，15，1： | 1 |
| 12 | Testing unconstrained opti- mizatian software显示文摘 | More J J Garbow B S Hillstrome K E | | 0，，07： | 1 |
| 13 | Testing uncon- strained optimization software显示文摘 | MORI J J GARBOW B S Hillstrom K E | | ACM Transactions on Mathematical Software0，7，1： | 1 |
| 14 | The effects oflimb dominance and fatigue on running biomechanics 显示文摘 | Brown A M Zifchock R A Hillstrom H J | 2014 | Gait & posture2014，39，3： | 1 |
| 15 | 1,3- Dichloropropenes-in the preparation of thiazole derivatives-2- chloro-5-chlommethyhhiazole and 5-hydroxymethylthiazole显示文摘 | Hillstrom G F Hockman M A Murugan R | 2001 | Arkivoc2001，，： | 1 |
| 16 | Testing unconstrained optimization software显示文摘 | More J J Gaxbow B S Hillstrome K E | 1981 | ACM Transactions on Mathematical Software1981，7，1： | 1 |
| 17 | Testing unconstrained optimization software显示文摘 | MORE J J GARBOW B S HILLSTROM K E | 1981 | ACM Transactions on Mathematical Soft ware1981，7，1： | 1 |
| 18 | 1,3- Dichloropropenes- in the preparation of thiazole derivatives- 2- chloro-5-chloromethylthiazole and 5-hydroxymethylthiazole 显示文摘 | Gregory F Hillstrom M A Murugan H R | 2001 | Arkivoc2001，6，： | 1 |
| 19 | Testing unconstrained optimization software 显示文摘 | Mor'e J J Garbow B S Hillstrom K E | 1981 | ACM Trans Math Soft-ware1981，7，1： | 1 |
| 20 | Testing unconstrained optimization software显示文摘 | Mor J J Garbow B S Hillstrome K E | 1981 | ACM Transactions on Mathematical Software1981，7，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员