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| 1 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 2 | Diagnostic and therapeutic role of endoscopic retrograde cholangiopancreatography in biliary rhabdomyosarcoma显示文摘Biliary rhabdomyosarcoma (BRMS) is an uncommon childhood malignancy which has been managed surgically. We present a case of a 3-year-old boy with BRMS, in whom endoscopic retrograde cholangiopancreatography (ERCP) was successfully used both diagnostically and therapeutically, thus obviating the need for surgery and its attendant risks of morbidity and mortality. We conclude that ERCP is an effective alternative to surgery for BRMS in some patients. | Ryan W Himes Isaac Raijman Milton J Finegold Heidi V Russell Douglas S Fishman | 2008 | World Journal of Gastroenterology2008，14，30： | 2 |
| 3 | Guidlines for overweight in adolesent preventative services:recommendations from an expert committee显示文摘 | Himes J Dietz W | 1994 | Am J Nutr1994，59，： | 1 |
| 4 | Guidelines for overweight in adolescent preventive services:recommendations from an expert committee显示文摘 | Himes J Dietz W | 2004 | Am J Clin Nutr2004，59，： | 1 |
| 5 | A Method for the Determination of the Cement Content of Plastic Concrete 显示文摘 | HIME W C WILLIS R A | 1955 | ASTM Intl Bull1955，209，： | 1 |
| 6 | Sulfate attack,' or is it显示文摘 | Hime W G Mather B | | 0，，05： | 1 |
| 7 | Concentration of hydrophobic organic compounds and extraction of protein using alkylammoniosulfate zwitterionic surfactant mediated phase separations (Cloud Point Extractions)显示文摘 | Saitoh T Hime W L 1991 | 1991 | Anal Chem1991，63，： | 1 |
| 8 | Salt hydration distress显示文摘 | W G Hime R A Martinek L A Backus | 2001 | Concr Int2001，23，10： | 1 |
| 9 | Sulfate attack or is it显示文摘 | W G Hime B Mater | 1999 | Cem Concr Res1999，29，： | 1 |
| 10 | Accelerated protocol for measurement of carbonation through a crack surfaee显示文摘 | SULLIVAN-GREEN L HIME W DOWDING C | 2007 | Cement and Concrete Research2007，，37： | 1 |
| 11 | Chloride-Induced Corrosion显示文摘 | Erlin B Hime W | 1985 | Concrete International1985，15，9： | 1 |
| 12 | Stereochemistry of the human macular carotenoids显示文摘 | Bone R A Landrum J T Hime G W | 1993 | Invest Ophthalmol Vis Sci1993，34，： | 1 |
| 13 | 'Sulfate attack',or is it显示文摘 | HIME W G MATI~ER B | 1999 | Cement and Con- crete Research1999，29，5： | 1 |
| 14 | Investigation of prestressed concrete railway tie distress显示文摘 | MIELENZ R C MARUSIN S L HIME W G | 1995 | Concr Int1995，17，12： | 1 |
| 15 | Modifying conven- tional high-performance liquid chromatography systems to achieve fast separations with Fused-Core columns: A case study 显示文摘 | Alexander A J Waeghe T J Himes K W | 2011 | Journal of Chromatography A2011，1218，32： | 1 |
| 16 | Cocaethylene :A unique cocaine metabolite displays high affinity for the dopamine transporter显示文摘 | Hearn W L Flynn D D Hime G W | 1991 | J Neurochem1991，56，： | 1 |
| 17 | Chloride profiles in salty concrete 显示文摘 | West R E Hime W G | 1985 | Material Performance1985，24，7： | 1 |
| 18 | 'Sulfate Attack,' Or Is It? 显示文摘 | Hime W G Mather B | 1999 | Cement and Concrete Research1999，29，： | 1 |
| 19 | Structure/ function analysis of the Bacillus subtilis sporulation- specific transcription factor SpolID 显示文摘 | Himes F R Wedemever W J Kroos L | 2004 | Abstracts of the General Meeting of the American Society for Microbiology2004，104，： | 1 |
| 20 | Micro - RNA mediated regulation of proliferation, self - renewal and differentiation of mammalian stem cells显示文摘 | HIME G R W GREGORY S | 2009 | Cell Adhesion & Migration2009，3，4： | 1 |
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