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| 1 | Comparison of visual analogue scale (VAS) and the Nasal Obstruction Symptom Evaluation (NOSE) score in evaluation of post septoplasty patients显示文摘Objective:To compare and correlate the efficacy of the NOSE score&the VAS score in determining the symptomatic benefit in patients undergoing septoplasty.Materials and methods:Eighty patients with deviated nasal septum undergoing septoplasty were included in the study.NOSE score&VAS score(out of 100)was documented before and after surgery.Results were correlated and compared statistically.Results:In the NOSE score,the most bothersome symptom was trouble breathing through the nose(85.83);followed by Nasal obstruction or blockage(82.50).Wilcoxon test showed significant improvement with NOSE score and VAS score in all patients at 1 month and 3 months.Spearman’s coefficient showed a positive correlation between the two,though the score improvement and patient satisfaction rate was significantly high with NOSE score.Conclusions:NOSE score and the VAS score both provide effective framework for evaluating treatment responses after septoplasty.However,the NOSE score showed higher improvement and better patient satisfaction rate when used to measure of nasal obstruction as compared to the VAS score. | Radhika Hiren Shukla Sanjana Vijay Nemade Kiran Jaywant Shinde | 2020 | World Journal of Otorhinolaryngology-Head and Neck Surgery2020，6，1： | 28 |
| 2 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 3 | 营养不良:实验室指标vs营养评估显示文摘营养不良是患者并发症发生率和病死率的一项独立危险因素,并造成医疗费用的增高。然而,由于对营养不良没有一个统一的定义,也没有一个标准的营养不良筛查/诊断方法,导致全世界各地的医生对营养不良在认识上十分混乱,各地的临床实践也有着各不相同的标准。作为营养不良的危险因素,炎症的作用近期已被证实。组织学上,一些血清蛋白如白蛋白和前白蛋白被广泛用于监测患者的营养状态。然而,目前的研究热点是采用恰当的营养状态体格检查(NFPE)来诊断营养不良。目前认为,实验室指标本身不太可靠,只能作为NFPE的一个补充。今后的研究中需要筛选出一些诊断营养不良的血清生物学标志物,这些标志物必须是不受炎症状态影响且具有无创及价格相对低廉的优势。然而,一个完全的NFPE在营养不良的诊断中具有无可替代的作用。 | Shishira Bharadwaj Shaiva Ginoya Parul Tandon Tushar D.Gohel John Guirguis Hiren Vallabh Andrea Jevenn Ibrahim Hanouneh | 2016 | Gastroenterology Report2016，4，4： | 5 |
| 4 | Accuracy and Clinical Usefulness of Intracerebral Hemorrhage Grading Scores: A Direct Comparison in a UK Population显示文摘 | Adrian R. Parry-Jones Kamran A. Abid Mario Di Napoli Craig J. Smith Andy Vail Hiren C. Patel Andrew T. King Pippa J. Tyrrell | 2013 | Stroke2013，，7： | 2 |
| 5 | Hypolipidemic activity of a hydroalcoholic extract of Cyperus scariosus Linn. root in guinea pigs fed with a high cholesterol diet显示文摘Lipid-lowering and antioxidant activities of a hydroalcoholic extract of Cyperus scariosus Linn. root(HCS) were evaluated in guinea pigs fed with a high cholesterol diet. Serum lipid profile(total cholesterol, triglycerides, LDL-C, VLDL-C, and HDL-C), atherogenic indices and serum enzymes(ALT, AST, ALP, LDH, and CK-MB) were performed in each group at 0 days and at the end of 60 days. Histological study of liver and kidney was done in groups 1, 2, 5, 6 and 7. The total phenolic and flavonoid content in HCS and its antioxidant activity were evaluated by the DPPH assay. Both doses of HCS decreased serum lipid profile and atherogenic indices(P < 0.05). HCS has lipid lowering, immunosuppressive and antioxidant properties, and mays have value in atherosclerosis prevention. The higher dose of HCS also reduced serum AST, ALP, and LDH levels and rosuvastatin increased AST and ALP levels(P < 0.05). Histology of the liver showed decreased lipid accumulation and improvement in hepatocytes in HCStreated animals. The antioxidant activity of HCS may be responsible for its lipid lowering and cytoprotective action. HCS had significant lipid lowering and antioxidant activity, which; may be due to the phenolic compounds. HCS may be a safe and cost effective alternative to current statin therapy for patients with dyslipidaemia. | Hiren M.Chawda Divyesh R.Mandavia Pravin H.Parmar Seema N.Baxi Chandrabhanu R.Tripathi | 2014 | Chinese Journal of Natural Medicines2014，12，11： | 2 |
| 6 | MATLAB-Based modeling to study the effects of partial shading on PV array characteristics显示文摘 | PATEL Hiren AGARWAL Vivek | 2008 | IEEE Transactions on Energy Conversion2008，23，1： | 1 |
| 7 | Macrophytes in phyteremediation of heavy metal contaminated water and sediments in Pariyej community reserve,Gujarat,India显示文摘 | KUMAR N HIREN S RITA N K | | 0，，02： | 1 |
| 8 | Matlab-Based Modeling to Study the Effects of Partial Shading on PV Array Characteristics 显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE transactionsonenergy conversion (S0885-8969)2008，23，1： | 1 |
| 9 | Maximum Power Point Tracking Scheme for PV Systems Operating Under Partially Shaded Conditions 显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE Transactions on Industrial Electronics2008，55，4： | 1 |
| 10 | Hypolipidaemic and antioxidant effect of Enicostemma littorale Blume aqueous extract in cholesterol fed rats显示文摘 | Vihas T. Vasu Hiren Modi Jyoti V. Thaikoottathil Sarita Gupta | 2005 | Journal of Ethnopharmacology2005，，1： | 1 |
| 11 | Endoscopic ultrasonography‐guided cholecystogastrostomy in patients with unresectable pancreatic cancer using anti‐migratory metal stents: A new approach显示文摘 | Jessica Widmer Paloma Alvarez Monica Gaidhane Naveen Paddu Hiren Umrania Reem Sharaiha Michel Kahaleh | 2014 | Digestive Endoscopy2014，，4： | 1 |
| 12 | Maximum power point tracking scheme for PV systems operating under partially shaded conditions显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE Transactions on Industrial Electronics2008，55，4： | 1 |
| 13 | Maximum Power Point Tracking Scheme for PV Systems Operating Under Partially Shaded Conditions显示文摘 | Hiren P Vivek A | 2008 | 1EEE Transactions on Industrial Electronics2008，55，4： | 1 |
| 14 | Matlab-based modeling to study the effects of partial shading on PV array characteristics显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE Transactions on Energy Conversion2008，23，1： | 1 |
| 15 | Maximum power point tracking scheme for PV systems operating under partially shaded conditions显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE Transactions on Industrial Electronics2008，55，4： | 1 |
| 16 | Overview of Laborato- ry and Modeling Studies of Carbon Dioxide Sequestration in Coal beds 显示文摘 | Theodore T Hiren P Fayya Z N | 2004 | Industrial and Engineering Chemistry Research2004，43，12： | 1 |
| 17 | Polyarylene networks via bergman cyclopolymerization of bis-ortho-diynyl arenes 显示文摘 | Jr Dennis W Smith Shah Hiren V Perera Kankanige Prasanna Udena | 2007 | Advanced Functional Materials2007，17，12： | 1 |
| 18 | Application of UPLC-MS/MS for separation and quantification of 3α-Hydroxy Tibolone and comparative bioavailability of two Tibolone formulations in healthy volunteers显示文摘A novel,fast,sensitive and robust method based on ultra-performance liquid chromatography coupled to atmospheric pressure electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) has been developed to separate two Tibolone stereoisomers i.e.,3α-Hydroxy Tibolone and 3β-Hydroxy Tibolone and to quantify 3α-Hydroxy Tibolone using p-toulenesulfonyl isocyanate (PTSI) as a derivatizing reagent in human plasma.3α-Hydroxy Tibolone-13 CD3 was used as an internal standard (IS).The analyte and IS were extracted from human plasma by liquid-liquid extraction using ethyl acetate.Extracted samples were analyzed by UPLC-ESI-MS/MS.Chromatography was performed using binary gradient on UPLC analytical column.A linear calibration curve over the range of 0.100-35.000 ng/mL was obtained and lower limit of quantification (LLOQ) was 0.100 ng/mL demonstrating acceptable accuracy and precision.This method was successfully applied to a pharmacokinetic study in order to compare a test Tibolone 2.5 mg formulation vs.a reference 2.5 mg Tibolone tablet formulation in 50 post-menopausal/surgical menopause female human volunteers under fasting conditions.It is concluded that test formulation of Tibolone is bioequivalent to reference formulation of Tibolone. | Vijay P.Shinde Ashutosh Pudage Arvind Jangidi Hiren Mistri P.K.Patel | 2013 | Journal of Pharmaceutical Analysis2013，3，4： | 1 |
| 19 | MATLAB-based modeling to study the effects of partial shading on PV array characteristics 显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE Transactions on Energy Conversion2008，23，1： | 1 |
| 20 | MATLAB-Based Modeling to Study the Effects of Partial Occlusion on PV Array Characrerristics显示文摘 | Hiren Patel Vivek Agarwal | | 0，，1： | 1 |
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