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| 1 | Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma显示文摘Although liver resection is considered the most effective treatment for hepatocellular carcinoma(HCC), treatment outcomes are unsatisfactory because of the high rate of HCC recurrence. Since we reported hepatitis B e-antigen positivity and high serum hepatitis B virus(HBV) DNA concentrations are strong risk factors for HCC recurrence after curative resection of HBV-related HCC in the early 2000 s, many investigators have demonstrated the effects of viral status on HCC recurrence and post-treatment outcomes. These findings suggest controlling viral status is important to prevent HCC recurrence and improve survival after curative treatment for HBV-related HCC. Antiviral therapy after curative treatment aims to improve prognosis by preventing HCC recurrence and maintaining liver function. Therapy with interferon and nucleos(t)ide analogs may be useful for preventing HCC recurrence and improving overall survival in patients who have undergone curative resection for HBV-related HCC. In addition, reactivation of viral replication can occur after liver resection for HBV-related HCC. Antiviral therapy can be recommended for patients to prevent HBV reactivation. Nevertheless, further studies are required to establish treatment guidelines for patients with HBVrelated HCC. | Shoji Kubo Shigekazu Takemura Shogo Tanaka Hiroji Shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata | 2015 | World Journal of Gastroenterology2015，21，27： | 19 |
| 2 | ApoE isoforms,treatment of diabetes and the risk of coronary heart disease显示文摘AIM:To analyze the risk of coronary heart disease in patients with type 2 diabetes mellitus(T2DM)receiving standard medical treatment.METHODS:We performed a retrospective chart analysis of 269 middle-aged patients(age 45-64 years,mean age,53.9±5.5 years)with T2DM and without atherosclerotic cardiovascular events who underwent typing to determine their apolipoprotein E(apoE)isoforms.The apoE isoforms were determined using isoelectric focusing,followed by immunoblotting.We retrospectively evaluated the charts of the 269 patients,recorded between their first visit to the hospital(the study's start point,between 1987 and 1992)and the occurrence of an atherosclerotic cardiovascular event(the study's endpoint)or January 2004,whichever came first.The age-adjusted mean values and the prevalences of covariates were calculated to compare the laboratory data among the apoE phenotypes.To investigate the association of risk factors with the incidence of coronary heart disease during the follow-up period,monovariate and multivariate Cox regression models were used.RESULTS:At enrollment,the mean serum low density lipoprotein(LDL)cholesterol levels were lowest(2.92± 0.89 mmol/L)among the subjects with apoE2(apoE2/2 or apoE2/3)and highest(3.52±0.77 mmol/L)among the subjects with apoE4(apoE3/4 or apoE4/4).No significant differences in mean age or the percentage of smokers were observed among the three groups.Furthermore,no significant differences were observed in the systolic and diastolic blood pressures,body mass index,HbA1c level or serum triglyceride levels among the three groups.There were 47 cases of coronary heart disease over 3285 person-years of follow-up.An age-adjusted multivariate Cox proportional model identified diabetic retinopathy(hazard ratio,2.38,95% CI:1.28-4.43,P=0.006),a high systolic blood pressure(hazard ratio,1.04,95%CI:1.02-1.06,P<0.001) and high HbA1c values(hazard ratio,1.19,95%CI:1.02-1.38,P=0.0029),but not the LDL cholesterol value at enrollment(hazard ratio,1.01,95%CI:0.97-1.05,P=0.77)nor the specific apoE isoform,as significant predictors of coronary heart disease.CONCLUSION:Under standard medical treatment of diabetes,including the control of LDL cholesterol levels,the apoE4 isoform was not associated with coronary heart disease among T2DM patients. | Hideki Ehara Ritsuko Yamamoto-Honda Hiroji Kitazato Yoshihiko Takahashi Shoji Kawazu Yasuo Akanuma Mitsuhiko Noda | 2012 | World Journal of Diabetes2012，3，3： | 3 |
| 3 | Hepatitis B virus infection in Indonesia显示文摘Approximately 240 million people are chronically infected with hepatitis B virus(HBV),75% of whom reside in Asia. Approximately 600000 of infected patients die each year due to HBV-related diseases or hepatocellular carcinoma(HCC). The endemicity of hepatitis surface antigen in Indonesia is intermediate to high with a geographical difference. The risk of HBV infection is high in hemodialysis(HD) patients,men having sex with men,and health care workers. Occult HBV infection has been detected in various groups such as blood donors,HD patients,and HIVinfected individuals and children. The most common HBV subgenotype in Indonesia is B3 followed by C1. Various novel subgenotypes of HBV have been identified throughout Indonesia,with the novel HBV subgenotypes C6-C16 and D6 being successfully isolated. Although a number of HBV subgenotypes have been discovered in Indonesia,genotyperelated pathogenicity has not yet been elucidated in detail. Therefore,genotype-related differences in the prognosis of liver disease and their effects on treatments need to be determined. A previous study conducted in Indonesia revealed that hepatic steatosis was associated with disease progression. Pre-S2 mutations and mutations at C1638 T and T1753 V in HBV/B3 have been associated with advanced liver diseases including HCC. However,drug resistance to lamivudine,which is prominent in Indonesia,remains obscure. Although the number of studies on HBV in Indonesia has been increasing,adequate databases on HBV infection are limited. We herein provided an overview of the epidemiology and clinical characteristics of HBV infection in Indonesia. | Shoji Kubo Shigekazu Takemura Shogo Tanaka Hiroji Shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata | 2015 | World Journal of Gastroenterology2015，21，38： | 2 |
| 4 | Mechanisms and anatomical risk factors of pneumothorax after Bevacizumab use:A case report显示文摘BACKGROUND Bevacizumab is an antiangiogenic agent,and that synergizes with chemotherapeutic drugs.When used in combination therapies,Bevacizumab is associated with adverse events such as hemorrhage,gastrointestinal perforation,delayed wound healing,and pneumothorax.However,the molecular mechanisms underlying these adverse events are not fully understood.CASE SUMMARY A 45-year-old female with multiple lung metastases that were derived from primary breast cancer,was placed on Bevacizumab+paclitaxel therapy,since this combination has a potent antitumor effect.She reported dyspnea before cycle 3,day 1 and we therefore ran a chest X-ray,which detected a right pneumothorax.The coronal plane computed tomography revealed that one solid mass rapidly necrosed and was replaced by a cavity that passed through the bronchus in the right lower lobe.The cavity eventually ruptured the pleura and made the bronchopleural fistula that led to this pneumothorax.Thoracic cavity drainage using an intercostal catheter was performed.On the 7th day of drainage,the patient was discharged from our hospital on recovery.Recurrence of pneumothorax was not reported,and continuation of chemotherapy was made possible by changing the regimen.CONCLUSION Patients with lung metastases surrounding the bronchi and on the pleura should be monitored for pneumothorax by Bevacizumab-containing chemotherapies. | Yuri Ozaki Akiyo Yoshimura Masataka Sawaki Masaya Hattori Naomi Gondo Haruru Kotani Yayoi Adachi Ayumi Kataoka Kayoko Sugino Nanae Horisawa Yuka Endo Kazuki Nozawa Shoko Sakamoto Hiroji Iwata | 2020 | World Journal of Clinical Oncology2020，11，7： | 2 |
| 5 | New bitter C27 and C30 Terpenoids from the Fungus Ganoderma luicidum (Reishi) 显示文摘 | TSUYOSHI N HIROJI S TAKANORI K | 1985 | Agric Boi Chem1985，49，6： | 1 |
| 6 | Evidence on the strain-specific terpenoid pattern of Ganoderma lacidum显示文摘 | Hiroji Sato Sachiko Shirasu | 1986 | Agr Biol Chem1986，50，8： | 1 |
| 7 | Ganoderiol A and B,new triterpenoids from the fungus Ganoderma lucidum (Reishi)显示文摘 | Tsuyoshi Nishitoba Sachiko Shirasu | 1986 | Agr Biol Chem1986，50，11： | 1 |
| 8 | Chargevoltage curves of surge corona on transmission lines: two measurement methods显示文摘 | Taku Noda Takao Ono Hiroji Mat subara | 2003 | IEEE Transactions on Power Delivery2003，18，1： | 1 |
| 9 | Triterpenoids from the fungus Ganoderma lucidum显示文摘 | Hiroji Sato Sadao Sakamura | 1987 | Phytochemisiry1987，26，6： | 1 |
| 10 | Novel triterpenoids from the mycelial mat at the previous stage of fruiting of Ganoderma lucidum显示文摘 | Hiroji Sato Sachiko Shirasu | 1987 | Agr Biol Chem1987，51，2： | 1 |
| 11 | New terpenoids,ganoderic acid J and ganolucidic acid C from the fungus Ganoderma lucidum显示文摘 | Hiroji Sato Sadao Sakamura | 1985 | Agr Biol Chem1985，49，12： | 1 |
| 12 | New terpenoids from Ganoderma lucidum and their bitterness显示文摘 | Hiroji Sato Sadao Sakamura | 1985 | Agr Biol Chem1985，49，5： | 1 |
| 13 | New bitter C27 and C30 terpenoids from the fungus GanodermaZucidum(Reishi) 显示文摘 | Tsuyoshi Nishitoba Hiroji Sato Takanori Kasai | 1985 | Agric Biol Chem1985，49，6： | 1 |
| 14 | Ureteroscopy assisted retrograde nephrostomy: a new technique for percutaneous nephrolithotomy (PCNL)显示文摘 | Takashi Kawahara Hiroki Ito Hideyuki Terao Minoru Yoshida Takehiko Ogawa Hiroji Uemura Yoshinobu Kubota Junichi Matsuzaki | 2011 | BJU International2011，，4： | 1 |
| 15 | New terpenoids,ganolucidic acid D,ganoderic acid L,lucidone C and lucidenic acid G,from the fungus Ganoderma lucidum显示文摘 | Hiroji Sato Sadao Sakamura | 1986 | Agr Biol Chem1986，50，3： | 1 |
| 16 | New bitter C27 and C30 terpenoids from the fungus Ganodermalucid- um(Reishi)显示文摘 | Tsuyoshi Nishitoba Hiroji Sato Takanori Kasai | 1984 | Agric Biol Chem1984，48，11： | 1 |
| 17 | Stone area and volume are correlated with operative time for cystolithotripsy for bladder calculi using a holmium: yttrium garnet laser显示文摘 | Takashi Kawahara Hiroki Ito Hideyuki Terao Takehiko Ogawa Hiroji Uemura Yoshinobu Kubota Junichi Matsuzaki | 2012 | Scandinavian Journal of Urology and Nephrology2012，，4： | 1 |
| 18 | Effect of extract of oyster on lipid metabolism in rats显示文摘 | Yoshiyuki Kimura Hiroji Ohminami | 1998 | Journal of Ethnopharmacology1998，59，： | 1 |
| 19 | Novel mycelial cormponents,ganoderic acid Mg,Mh,Mi,Mj,and Mk,from the fungus Ganoderma lucidum显示文摘 | Hiroji Sato Sadao Sakamura | 1987 | Agr Biol Chem1987，51，4： | 1 |
| 20 | Alogliptin, a dipeptidylpeptidase-4 inhibitor, for patients with diabetes mellitus type 2, induces tolerance to focal cerebral ischemia in non-diabetic, normal mice显示文摘 | Dong Yang Yukako Nakajo Koji Iihara Hiroharu Kataoka Hiroji Yanamoto | 2013 | Brain Research2013，，： | 1 |
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