|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Natural regression of fibrosis in chronic hepatitis B显示文摘The fibrosis of liver cirrhosis was considered to be irreversible before the anti-viral drugs showed that it is reversible when they lead to continuous suppression of viral replication and inflammation. However, several reports previously showed that fibrosis of type B liver cirrhosis was almost completely absorbed after the natural remission of chronic inflammation. This phenomenon might not be limited to exceptional patients, but rather occur commonly, considering the dynamic clinical features of chronic hepatitis B(CHB), where inactive carrier stage normally follows aggravation of hepatitis and progression of fibrosis at the time of HBe Ag seroconversion. Thus, fibrosis levels of CHB as a hepatocellular carcinoma(HCC)-surveillance marker, particularly those of the inactive stage, could be underestimated, because some of them might have been(pre)cirrhotic in the past and recovered with the natural regression of fibrosis. We argue that cirrhosisinduced HCC mechanisms, rather than direct action of viral genome, may be more common than generally considered in CHB patients. This may have some impact on reconsidering the surveillance rationale for HCC in CHB, from where advanced HCCs tended to be missed. In addition, a molecular marker to assess the cancer-prone characteristics of the liver will definitely be needed to resolve the issue. | Shogo Ohkoshi Haruka Hirono Kazuhiko Watanabe Katsuhiko Hasegawa Kenya Kamimura Masahiko Yano | 2016 | World Journal of Gastroenterology2016，22，24： | 8 |
| 2 | Features of hepatocellular carcinoma in cases with autoimmune hepatitis and primary biliary cirrhosis显示文摘AIM: To characterize the clinical features of hepatocellular carcinoma (HCC) associated with autoimmune liver disease, we critically evaluated the literature on HCC associated with autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). METHODS: A systematic review of the literature was conducted using the Japana Centra Revuo Medicina database which produced 38 cases of HCC with AIH (AIH-series) and 50 cases of HCC with PBC (PBC-series). We compared the clinical features of these two sets of patients with the general Japanese HCC population. RESULTS: On average, HCC was more common in men than in women with AIH or PBC. While many patients underwent chemolipiodolization (CL) or transcatheter arterial embolization (TAE) (AIH-series: P = 0.048 (vs operation), P = 0.018 (vs RFA, PEIT); PBC-series: P = 0.027 (vs RFA, PEIT), others refused therapeutic interventions [AIH-series: P = 0.038 (vs RFA, PEIT); PBC-series: P = 0.003 (vs RFA, PEIT)].Liver failure was the primary cause of death among patients in this study, followed by tumor rupture. The survival interval between diagnosis and death was fairly short, averaging 14 ± 12 mo in AIH patients and 8.4 ± 14 mo in PBC patients. CONCLUSION: We demonstrated common clinical features among Japanese cases of HCC arising from AIH and PBC. | Takuya Watanabe Kenji Soga Haruka Hirono Katsuhiko Hasegawa Koichi Shibasaki Hirokazu Kawai Yutaka Aoyagi | 2009 | World Journal of Gastroenterology2009，15，2： | 5 |
| 3 | Spermatogenesis in aged rats after prenatal 3,3′,4,4′,5-pentachlorobiphenyl exposure显示文摘 | Shin Wakui Fumio Takagi Tomoko Muto Kiyofumi Yokoo Shyou Hirono Yasuko Kobayashi Kinji Shirota Fumiaki Akahori Yoshihiko Suzuki Hiroshi Hano Hitoshi Endou Yoshikatsu Kanai | 2007 | Toxicology2007，，2： | 3 |
| 4 | Impact of continuous positive airway pressure therapy for nonalcoholic fatty liver disease in patients with obstructive sleep apnea显示文摘BACKGROUND Obstructive sleep apnea(OSA)has been suggested as an independent risk factor for nonalcoholic fatty liver disease(NAFLD),and continuous positive airway pressure(CPAP)is the first-line therapy for OSA.AIM To clarify the efficacy of effective CPAP therapy on NAFLD of OSA patients by serum markers and transient elastography(TE)using FibroScan®(Echosens,Paris,France).METHODS We prospectively enrolled 123 consecutive patients with OSA who met the indications for CPAP.Liver fibrosis and steatosis were assessed using TE.Before and after 6 mo of CPAP therapy,serum markers and TE were assessed for all patients.The mean usage rate of CPAP therapy for 6 mo was arbitrarily calculated in each patient and expressed as“mean compliance index”(m-CI).RESULTS In 50 OSA patients with NAFLD,both aspartate aminotransferase(AST)and alanine aminotransferase(ALT)levels were significantly decreased after 6 mo of CPAP therapy.Univariate analysis showed that decreased body weight(BW),decreased body mass index(BMI),decreased AST level,decreased hemoglobin A1c,and high m-CI were significantly related with improved ALT level.In multivariate regression model adjusted for quantities of BW change during 6 mo of CPAP therapy,high m-CI tended to improve ALT level(P=0.051).All 17 OSA patients with NAFLD,high m-CI and no BMI changes showed significant improvements in AST and ALT levels.Meanwhile,no significant changes in TE data or serum fibrosis markers were seen.CONCLUSION Some NAFLD could be associated with chronic intermittent hypoxia due to OSA independent of BW changes.In those cases,adequate reoxygenation from effective CPAP therapy may improve NAFLD. | Haruka Hirono Kazuhiko Watanabe Katsuhiko Hasegawa Masaki Kohno Shuji Terai Shogo Ohkoshi | 2021 | World Journal of Clinical Cases2021，9，19： | 2 |
| 5 | Use of omentum or falciform ligament does not decrease complications after pancreaticoduodenectomy: Nationwide survey of the Japanese Society of Pancreatic Surgery显示文摘 | Masaji Tani Manabu Kawai Seiko Hirono Takashi Hatori Toshihide Imaizumi Akimasa Nakao Shinichi Egawa Takehide Asano Takukazu Nagakawa Hiroki Yamaue | 2012 | Surgery2012，，2： | 2 |
| 6 | A Central Pancreatectomy for Benign or Low-Grade Malignant Neoplasms显示文摘 | Seiko Hirono Masaji Tani Manabu Kawai Shinomi Ina Ryohei Nishioka Motoki Miyazawa Atsushi Shimizu Kazuhisa Uchiyama Hiroki Yamaue | 2009 | Journal of Gastrointestinal Surgery2009，，9： | 2 |
| 7 | 肝胰十二指肠切除术治疗胆道恶性肿瘤的指征显示文摘肝胰十二指肠切除术(hepatopancreatoduodenectomy,HPD)治疗胆道肿瘤的指征目前仍有争议,主要原因是HPD手术创伤大,术后死亡率和手术并发症发生率很高。该文回顾性总结11例HPD治疗进展期胆道恶性肿瘤的经验,探讨HPD的应用指征。1986-2004年日本Wakayama医科大学医院共收治219例胆道恶性肿瘤病人,包括146例胆管癌和73例胆囊癌,其中11例(5%)因弥漫性胆管癌或进展期胆囊癌需广泛清除肿瘤和转移淋巴结而进行了HPD手术治疗。 | Hirono S Tani M Kawai M 邹一平(摘) 萧荫祺(校) | 2006 | 中华肝胆外科杂志2006，12，11： | 2 |
| 8 | Dental pulp cell bank as a possible future source of individual hepatocytes显示文摘Mesenchymal stem cells(MSCs) as a source for regenerative medicine are now the subject of much clinical attention. There are high expectations due to their safety, low tumorigenic risk, and low ethical concerns. MSC therapy has been approved for acute graft-versus host diseases since 2015. Tooth-derived MSCs are known to have a great potential in their proliferation and differentiation capacities, even when compared with bone-marrow-derived MSCs. In particular, stem cells from human exfoliated deciduous teeth(SHEDs) are the best candidates for personal cell banking(dental pulp cell bank), because they can be obtained less invasively in the natural process of individual growth. SHEDs are known to differentiate into hepatocytes. There have been several studies showing the effectiveness of SHEDs on the treatment of liver failure in animal models. They may exert their effects either by repopulation of cells in injured liver or by paracrine mechanisms due to their immuneregulatory functions. Moreover, it may be possible to use each individuals' dental pulp cells as a future source of tailor-made differentiated hepatocytes in the context of a bioartificial liver or liver-on-a-chip to screen for drug toxicity. | Shogo Ohkoshi Haruka Hirono Taka Nakahara Hiroshi Ishikawa | 2018 | World Journal of Hepatology2018，10，10： | 2 |
| 9 | Phase I/II study of intraperitoneal docetaxel plus S-1 for the gastric cancer patients with peritoneal carcinomatosis显示文摘 | S. Fushida J. Kinoshita M. Kaji Y. Hirono F. Goda Y. Yagi K. Oyama Y. Sudo Y. Watanabe T. Fujimura | 2013 | Cancer Chemotherapy and Pharmacology2013，，5： | 2 |
| 10 | Regenerative medicine using dental pulp stem cells for liver diseases显示文摘Acute liver failure is a refractory disease and its pro-gnosis, if not treated using liver transplantation, is extremely poor. It is a good candidate for regenerative medicine, where stem cell-based therapies play a central role. Mesenchymal stem cells(MSCs) are known to differentiate into multiple cell lineages including hepatocytes. Autologous cell transplant without any foreign gene induction is feasible using MSCs, thereby avoiding possible risks of tumorigenesis and immune rejection. Dental pulp also contains an MSC population that differentiates into hepatocytes. A point worthy of special mention is that dental pulp can be obtained from deciduous teeth during childhood and can be subsequently harvested when necessary after deposition in a tooth bank. MSCs have not only a regenerative capacity but also act in an anti--inflammatory manner via paracrine mechanisms. Promising efficacies and difficulties with the use of MSC derived from teeth are summarized in this review. | Shogo Ohkoshi Hajime Hara Haruka Hirono Kazuhiko Watanabe Katsuhiko Hasegawa | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 2 |
| 11 | Magnetic thin films of cobalt nanocrystals encapsulated in graphite-like carbon, 显示文摘 | Hirono S Tomita T Umemura S | 1996 | Nature 19961996，772，： | 1 |
| 12 | Waterborne fluo-ropolymers for paint use 显示文摘 | Asakawa A Unoki M Hirono T | 2000 | Journal of Fluorine Chemistry2000，104，： | 1 |
| 13 | Time-domain simulation of electromagnetic field using a symplectic integrator显示文摘 | Hirono T | 1997 | IEEE Microwave Guided Wave Letters1997，7，9： | 1 |
| 14 | Angiotensin II receptor type 1 - mediated vascular oxidative stress and proinflammatory gene ex- pression in aldosterone - induced hypertension : the possible role of lo- cal rennin - angiotensin system 显示文摘 | Hirono Y Yoshimoto T Suzuki N | 2007 | Endocrinology2007，148，4： | 1 |
| 15 | Comparative immune responses in Japanese flounder, Paralichthys olivaceus after vaccination with viral hemorrhagic septicemia virus (VHSV) recombinant glycoprotein and DNA vaccine using a mi- croarray analysis显示文摘 | Byon J Y Ohira T Hirono I | 2006 | Vaccine2006，24，7： | 1 |
| 16 | C-reactive protein elevation predicts the occurrence of atrial structural remodeling in patients with paroxysmal atrial fibrillation 显示文摘 | Watanabe T Takeishi Y Hirono O | 2005 | Heart Vessels2005，20，： | 1 |
| 17 | Molecular analysis of eight biochemically unique Glucose- 6 - phosphate dehydrogenase variants found in Japan显示文摘 | Hisaichi Fujji | 1997 | The American Society of Hamatology1997，8912，： | 1 |
| 18 | A case report of superior vena cava reconst ruction using a heparing coated temporary bypass tube显示文摘 | Kaike T Hirono T Maruyma Y | 1990 | Nippon Kyobu Geka Gakkai Zasshi1990，38，2： | 1 |
| 19 | Expression of protease activated receptor-2 (PAR-2) in gastric cancer显示文摘 | Fujimoto D Hirono Y Goi T | | 0，，02： | 1 |
| 20 | The evaluation of new fluoropolymer emulsion for exterior paint use International, 1996,79:3 显示文摘 | Yamauchi M Hirono J Kadama S | 1996 | Surface Coating1996，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员