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| 1 | Is endoscopic papillary balloon dilatation really a risk factor for post-ERCP pancreatitis?显示文摘Endoscopic papillary balloon dilatation(EPBD) is useful for decreasing early complications of endoscopic retrograde cholangio-pancreatography(ERCP), including bleeding, biliary infection, and perforation, but it is generally avoided in Western countries because of a relatively high reported incidence of post-ERCP pancreatitis(PEP). However, as the efficacy of endoscopic papillary largeballoon dilatation(EPLBD) becomes widely recognized, EPBD is attracting attention. Here we investigate whether EPBD is truly a risk factor for PEP, and seek safer and more effective EPBD procedures by reviewing past studies. We reviewed thirteen randomised control trials comparing EPBD and endoscopic sphincterotomy(EST) and ten studies comparing direct EPLBD and EST. Three randomized controlled trials of EPBD showed significantly higher incidence of PEP than EST, but no study of EPLBD did. Careful analysis of these studies suggested that longer and higher-pressure inflation of balloons might decrease PEP incidence. The paradoxical result that EPBD with small-calibre balloons increases PEP incidence while EPLBD does not may be due to insufficient papillary dilatation in the former. Insufficient dilatation could cause the high incidence of PEP through the use of mechanical lithotripsy and stress on the papilla at the time of stone removal. Sufficient dilation of the papilla may be useful in preventing PEP. | Toshio Fujisawa Koichi Kagawa Kantaro Hisatomi Kensuke Kubota Atsushi Nakajima Nobuyuki Matsuhashi | 2016 | World Journal of Gastroenterology2016，22，26： | 23 |
| 2 | A prospective randomized trial of lafutidine vs rabeprazole on post-ESD gastric ulcers显示文摘AIM:To compare the effects of rabeprazole and lafutidine on post-endoscopic submucosal dissection(ESD) gastric ulcers.METHODS:Patients with gastric tumors indicated for ESD were prospectively studied.After ESD,all patients were treated with intravenous omeprazole for the first 3 d.Patients were then randomly assigned to oral lafutidine or rabeprazole.Ulcer size,ulcer size reduction rate,and ulcer stage were evaluated 4 wk later.Occurrence of complication was monitored throughout the 4-wk period.RESULTS:Sixty five patients were enrolled in the study,and 60 patients were subjected to the final analysis.In the lafutidine group(30 lesions in 29 patients),initial and 4-wk post-ESD ulcer sizes were 33.3 ± 9.2 and 10.5 ± 4.8 mm,respectively.In the rabeprazole group(34 lesions in 31 patients),the values were 34.7 ± 11.3 and 11.8 ± 6.7 mm,respectively.Ulcer size reduction rates in lafutidine and rabeprazole groups were 32.3% and 33.5%,respectively(P=0.974).Ulcer stage 4 wk post-ESD did not differ significantly between the two groups(P=0.868).Two cases in the rabeprazole group and no cases in the lafutidine group developed ulcer bleeding during the oral dose period,although the difference of bleeding rate between the two groups was not statistically significant(P=0.157).CONCLUSION:Lafutidine and rabeprazole have equivalent therapeutic effects on post-ESD gastric ulcers. | Tomohiko Richard Ohya Hiroki Endo Kei Kawagoe Tatsuro Yanagawa Katsuhiro Hanawa Ken Ohata Masako Asayama Kantaro Hisatomi Takuma Teratani Toshiaki Gunji Hajime Sato Nobuyuki Matsuhashi | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 7 |
| 3 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 4 | Effects of Early Intensive Blood Pressure-Lowering Treatment on the Growth of Hematoma and Perihematomal Edema in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT)显示文摘 | Craig S. Anderson Yining Huang Hisatomi Arima Emma Heeley Christian Skulina Mark W. Parsons Bin Peng Qiang Li Steve Su Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Lewis B. Morgenstern John Chalmers Ji Guang Wang | 2010 | Stroke2010，，2： | 3 |
| 5 | Regression model for stabilization energies associated with anion ordering in perovskite-type oxynitrides显示文摘Certain perovskite-type oxynitrides have bandgaps suitable for renewable hydrogen production via photocatalytic and photoelectrochemical water splitting under visible light.Understanding the ordering of oxide and nitride anions in these materials is important because this ordering affects their semiconductor properties.However, the numerous possible orderings complicate systematic analyses based on density functional theory(DFT) calculations using defined elemental arrangements.This work shows that anion ordering in large-scale supercells within perovskite-type oxynitrides can be rapidly predicted based on machine learning, using BaNbO2N(capable of oxidizing water under irradiation up to 740 nm) as an example.Machine learning allows the calculation of the total energy of BaNbO2N directly from randomly selected initial atomic placements without costly structural optimization, thus reducing the computational cost by more than 99.99%.Combined with the Metropolis Monte Carlo method, machine learning permits exploration of the stable anion orderings of large supercells without costly DFT calculations.This work therefore demonstrates a means of predicting the properties of functional materials having complex compositions based on the most realistic elemental arrangements in conjunction with reasonable computational loads. | Masanori Kaneko Mikiya Fujii Takashi Hisatomi Koichi Yamashita Kazunari Domen | 2019 | Journal of Energy Chemistry2019，28，9： | 2 |
| 6 | Improved method of plasma 8-Isoprostane measurement and association analyses with habitual drinking and smoking显示文摘AIM: To develop a simple and accurate method for quantifying 8-isoprostane in plasma by employing a combination of two-step solid-phase extraction of samples and a commercially available ELISA kit, and by this method to examine the effects of drinking and smoking habits against the levels of plasma 8-isoprostane in healthy Japanese volunteers.METHODS: Plasma 8-isoprostane was extracted with ODS gel suspension followed by NH2 Sep-Pak column. The 8-isoprostane fractions were assayed using a commercially available ELISA kit. We measured plasma 8-isoprostane levels in 157 healthy Japanese volunteers divided into three groups (64 non-habitual drinkers, 56 moderate drinkers and 37 habitual drinkers) according to their alcohol consumption per week. Genotypes of aldehyde dehydrogenase 2 (ALDH2) were also determined to investigate the plasma 8-isoprostane levels with reference to drinking habits. In addition, the plasma 8-isoprostane levels of 96 non-smokers and 61 smokers from the same subjects were compared.RESULTS: Our method fulfilled all the requirements for use in routine clinical assays with respect to sensitivity, intra- and inter-assay reproducibility, accuracy and dynamic assay range. Significant increases of plasma 8-isoprostane levels were observed in female habitual drinkers when compared with those of non-habitual drinkers (t = 5.494, P < 0.0001) as well as moderate drinkers (t = 3.542, P < 0.005), and 8-isoprostane levels were also significantly different between ALDH2*2/1 and ALDH2*1/1 in the female habitual drinkers (t = 6.930, P < 0.0001), suggesting that excessive drinking of alcohol may increase oxidization stress, especially in females. On the contrary, no significant difference of the plasma 8-isoprostane levels was observed between non-smokers and smokers.CONCLUSION: Our present method was proved to be a simple and accurate tool for measuring plasma 8-isoprostane. However, the clinical utility of plasma 8-isoprostane for drinking and smoking habits was limited since elevated 8-isoprostane levels were observed in female heavy drinkers, and no association was found between smokers and nonsmokers. | Soichi Kitano Hisashi Hisatomi Nozomu Hibi Katsumi Kawano Shoji Harada | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 7 | Detection of telomerase activity, telomerase RNA component, and telomerase reverse transcriptase in human hepatocellular carcinoma显示文摘 | Masaki Shimojima Fumihiko Komine Hisashi Hisatomi Toshihiro Shimizu Mitsuhiko Moriyama Yasuyuki Arakawa | 2004 | Hepatology Research2004，，1： | 2 |
| 8 | Triamcinolone-assisted parsplana vitrectomy improves the surgical procedures and decreases the post-operative blood-ocular barrier breakdown显示文摘 | Sakamoto T Miyazaki M Hisatomi T | 2002 | Graefes Arch Clin Exp Ophthalmol2002，240，6： | 1 |
| 9 | Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo 显示文摘 | Hisatomi T Sakamoto T Murata T Yamanaka I Oshima Y Hata Y | 2001 | Am J Pathol2001，158，4： | 1 |
| 10 | LDL Cholesterol and the Development of Stroke Subtypes and Coronary Heart Disease in a General Japanese Population The Hisayama Study显示文摘 | Tsuyoshi Imamura Yasufumi Doi Hisatomi Arima | 2009 | Stroke February2009，40，2： | 1 |
| 11 | improved glycemic control without an increase in severe hypoglycemic episodes in intensively treated patients with type 1 diabetes receiving morning,evening,or split dose insulin glargine显示文摘 | Garg SK Gottlieb PA Hisatomi ME | 2004 | Diabetes Res Clin Pract2004，66，1： | 1 |
| 12 | Flow cyto- metric isolation of endodermal progenitors from mouse salivary gland differentiate into hepatic and pancreatic lin- eages显示文摘 | Hisatomi Y Okumura K Nakamura K | 2004 | Hepatology2004，39，3： | 1 |
| 13 | Enhanced water oxidation on Ta3N5 photocatalysts by modification with alkaline metal salts显示文摘 | Ma S S K Hisatomi T Maeda K | 2012 | Journal of the American Chemical Society2012，134，19： | 1 |
| 14 | Effect of Prograf(FK506)on spermatogenesis in rats显示文摘 | Hisatomi A Fujihira S Fujimoto Y | 1996 | Toxicology1996，109，23： | 1 |
| 15 | Triamcinolone-assisted pars plana vitrectomy im-proves the surgical procedures and decreases the postoperativeblood-ocular barrier breakdown 显示文摘 | Sakamoto T Miyazaki M Hisatomi T Nakamura T Ueno A Ita-ya K | 2002 | Graefes Arch Clin ExpOphthalmol2002，240，6： | 1 |
| 16 | Characteristics,management and response to alteplase in China versus non-China participants of the ENCHANTED trial显示文摘Background The characteristics of patients with acute ischaemic stroke(AIS)and their management vary across regions,which may influence outcomes.We examined for differential patterns of outcome between China and non-China participants of the ENhanced Control of Hypertension And Thrombolysis strokE stuDy(ENCHANTED),which tested different alteplase doses in AIS.Methods ENCHANTED was an international,multicentre,open,blinded-endpoint trial of the effects of low-dose(0.6 mg/kg)versus standard-dose(0.9 mg/kg)intravenous alteplase on 90-day disability outcomes and symptomatic intracerebral haemorrhage(sICH)in 3310 patients with AIS.Results Participants(n=1419,48%)in China were younger,and more often male,hypertensive and with prior stroke and coronary artery disease,but less likely to have atrial fibrillation and use antihypertensive,antithrombotic and lipid-lowering agents,compared with non-China patients with AIS.Although China participants had more AIS due to large artery occlusion,were treated later and had differing ancillary management,there was no significant difference in 90-day modified Rankin scale scores 2–6(55.6% vs 47.8%;OR,adjusted for baseline and management factors 0.87(95%CI 0.71 to 1.07;p=0.20))and risk of sICH(Safe Implementation of Thrombolysis in Stroke-Monitoring Study criteria:1.4% vs 1.8%;p=0.12)compared with non-China participants.There was no heterogeneity in the treatment effects of low-dose versus standard-dose alteplase between China and non-China participants.Conclusion Patients with AIS recruited to the ENCHANTED trial in China had similar outcomes in response to thrombolysis treatment despite significantly differing demographic,clinical and management factors to patients with AIS in other regions. | Lily Song Xia Wang Thompson Robinson Richard I Lindley Hisatomi Arima Pablo M Lavados Xiaoying Chen John Chalmers Craig S Anderson | 2017 | Stroke & Vascular Neurology2017，2，2： | 1 |
| 17 | Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival显示文摘 | SHICHIRI M YOSHINAGA K HISATOMI H | 2002 | Cancer Res2002，62，1： | 1 |
| 18 | Triamcinolone-assisted pars plana vitrectomy improves the surgical procedures and decreases the post-operative blood-ocular barrier breakdown 显示文摘 | Sakamoto T Miyazaki M Hisatomi T | 2002 | Graefes Arch Clin Exp Ophthalmol2002，240，6： | 1 |
| 19 | Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy 显示文摘 | Nagao K Kanamaru T | 1999 | Int J Oncol1999，14，4： | 1 |
| 20 | Enhanced water oxidation on Ta3Ns photocatalysts by modification with alkaline metal salts显示文摘 | MA S HISATOMI T MAEDA K | 2012 | JAm Chern Soc2012，134，19： | 1 |
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