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| 1 | Stronger inhibition of gastric acid secretion by lafutidine, a novel H_2 receptor antagonist, than by the proton pump inhibitor lansoprazole显示文摘AIM: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. METHODS: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. RESULTS: The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. CONCLUSION: In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidinethan by LPZ. | Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，15： | 3 |
| 2 | Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers显示文摘AIM: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. METHODS: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was perform- ed on the day of treatment. Blood samples were also collected after the administration of each drug. RESULTS: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. CONCLUSION: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg. | Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，13： | 2 |
| 3 | Evaluation and modeling of performance of anode-supported solid oxide fuel cell 显示文摘 | Yakabe H Hishinuma M Uratani M | 2000 | Journal of Power Sources2000，86，12： | 1 |
| 4 | The Performance and self-starting of a PEFC below freezing 显示文摘 | Kagami F Hishinuma Y Chikahisa T | 2001 | Thermal Science and Engineering2001，9，4： | 1 |
| 5 | HepatoceUular o11- eofetal protein,glypiean 3 is a sensitive marker for alpha - feto- protein - producing gastric carcinoma 显示文摘 | Hishinuma M Ohashi KI Yamauehi N et 81 | 2006 | Histopathalogy2006，49，5： | 1 |
| 6 | Biologically active human and mouse nerve growth factors secreted by the yeast Saccharomyces cerevisiae显示文摘 | Masafumi Nishizawa Fumiko Ozawa Takako Higashizaki Keiko Hirai Fumio Hishinuma | 1993 | Applied Microbiology and Biotechnology1993，，5： | 1 |
| 7 | The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma显示文摘 | Yamauchi N Watanabe A Hishinuma M | | 0，，12： | 1 |
| 8 | The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma显示文摘 | Yamauchi N Watanabe A Hishinuma M | 2005 | Mod Pathol2005，，： | 1 |
| 9 | Difference in urinary LTE4 and 11-dehydro-TXB2 excretion in asthmatic patients显示文摘 | Suzuki N Hishinuma T Abe F | 2000 | Prostaglandins Other Lipid Mediat2000，62，4： | 1 |
| 10 | Low-activaitonferritic and martensitci steels for fusion application显示文摘 | Kphyama A Hishinuma A Gelles D S | 1996 | Journalof Nuclear Materials1996，，： | 1 |
| 11 | Systematic review on the short-termefficacy and safety of nicorandil for stable angina pectoris in comparison withthose ofβ-blockers,nitrates and calcium antagonists显示文摘 | Hanai Y Mita M Hishinuma S | 2010 | J PharmaceuticalSociety of Japan2010，130，： | 1 |
| 12 | Thin-film piezoelectric unimorph actuator-based deformable mirror with a transferred silicon membrane 显示文摘 | Yang E H Hishinuma Y Cheng J G | 2006 | Journal of Microelectromechanical Systems2006，15，5： | 1 |
| 13 | Hepatocellular oncofetal protein, glypican 3 is a sensitive marker for alpha-fetoprotein-producing gastric carcinoma 显示文摘 | Hishinuma M Ohashi KI Yamauchi N | 2006 | Histo- pathology2006，49，5： | 1 |
| 14 | Hepatocellular on- eofetal protein, glypican-3 is a sensitive marker for alpha-fetopro- rein-producing gastric carcinoma显示文摘 | Hishinuma M Ohashi KI Yamauchi N | 2006 | Histopathology2006，49，5： | 1 |
| 15 | Stimulatory effects of insulin on the development of bovine embryos fertilized in vitro显示文摘 | Matsui M Takahashi Y Hishinuma M | 1995 | J Vet Med Sci1995，57，2： | 1 |
| 16 | New dry touch fabric ' SIL- LOOK AIRLY' 显示文摘 | SATO M KINOSHITA N HISHINUMA S | 1998 | Journal of the Tex- tile Machinery Society of Japan1998，54，9： | 1 |
| 17 | Molten carbonate fuel cell power generation 显示文摘 | Hishinuma Y Kunikata M | 1997 | ENERGY CONVERSION AND MANAGEMENT1997，38，1013： | 1 |
| 18 | Analysis of the relations between the shape of the reconstructed tongue and postoperative functions after subtotal or total glossectomy 显示文摘 | Kimata Y Sakuraba M Hishinuma S | 2003 | Laryngoscope2003，113，5： | 1 |
| 19 | Evaluation and modeling of performance of anodesupported solid oxide fuel cell显示文摘 | YAKABE H HISHINUMA M URATANI M | 2000 | Power Sources2000，86，12： | 1 |
| 20 | Microstructure of welded and thermal-aged low activation steel F82H IEA heat显示文摘 | Sawai T Shiba K and Hishinuma A | 2000 | Journal of Nucleal Materials2000，，1： | 1 |
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