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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle显示文摘 | Ho R C Alcazar O Fujii N | 2004 | Am J Physiol Regul Integr Comp Physiol2004，286，2： | 1 |
| 3 | Improvement of hybridyield by advanced backcross QTL analysis in elite maize显示文摘 | J C HO S R McCouch M E Smith | 2002 | Theor Appl Genet2002，105，： | 1 |
| 4 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 5 | Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma 显示文摘 | Poon R T Lau C P Ho J W Yu W C Fan S T Wong J | 2003 | Clin Cancer Res2003，9，： | 1 |
| 6 | Decomposition of Arbitrarily Shaped Morphological Structuring Elements显示文摘 | Ho C P Chin R T | 1995 | IEEE Trans PAMI1995，17，1： | 1 |
| 7 | Sensitivity and specificity of Epstein-Barr virus IGA titer in the diagnosis of nasopharyngeal carcinoma: a three-year institutional review 显示文摘 | Tsang R K Vlantis A C Ho R W | 2004 | Head Neck2004，26，7： | 1 |
| 8 | Dietary HDAC inhibitors : time to rethink weak ligands in cancer chemoprevention? 显示文摘 | DASHWOOD R H MYZAK M C Ho E | 2006 | Carcinogenesis2006，27，2： | 1 |
| 9 | Incentive Mechanisms,Fairness and Participation in Online Group-buy Auction显示文摘 | Kauffman R J Lai H Ho C T | 2010 | Electronic Commerce Research and Applications2010，15，9： | 1 |
| 10 | Mechanism of the su- peroxide scavenging activity of neoandrographolide - a natural product from Andrographis paniculata nees 显示文摘 | Kamdem R E Sang S Ho C T | 2002 | J Agr Food Chem2002，50，： | 1 |
| 11 | Statistical and dynamical analyses of generation mechanisms of solitary internal waves in the northern South China Sea 显示文摘 | Zheng Quanan Susanto R D Ho C R | 2007 | Journal of Geophysical Research-Oceans2007，112，3： | 1 |
| 12 | High resolution tsunami inversion for 2010 Chile earthquake显示文摘 | Wu T R Ho T C | 2011 | Natural hazards and earth system sciences2011，11，： | 1 |
| 13 | Effect of ubiquinol- 10 on citral stability and off-flavor formation in oil-in-water (O/W) nanoemulsions显示文摘 | ZHAO Q HO C T HUANG Q R | 2013 | Journal of Agricultural and Food Chemistry2013，，61： | 1 |
| 14 | Salt and pepper noise removal by median type noise detectors and detail preserving regularization显示文摘 | Chan R H Ho C W Nikolova M | 2005 | IEEE Trans Image Processing2005，14，10： | 1 |
| 15 | A Bayesian approach to problems in stochastic estimation and control显示文摘 | Ho Y C Lee R C K | 1964 | IEEE Trans Automat Contr1964，9，： | 1 |
| 16 | The markets for non-deliverable forwards in Asian currencies显示文摘 | Ma G N C Ho R N McCauley | 2004 | BIS Quarterly Review2004，6，： | 1 |
| 17 | Salt-and-pepper noise removal by median-type noise detectors and detail-preserving regularization显示文摘 | Chan R H Ho C W Nikolova M | 2005 | IEEE Transactions on Image Processing2005，14，10： | 1 |
| 18 | Narcissism, extraversionand adolescents,self - presentation on Facebook 显示文摘 | Ong E Y L Ang R P Ho J C M | 2010 | Personality andIndividual Differences2010，50，2： | 1 |
| 19 | Effects of d-cycloserineon MPTP-induced behavioral and neurological changes:Potential for treatment of Parkinson’s disease dementia显示文摘 | HO Y J HO S C PAWLAK C R | 2011 | Behav Brain Res2011，219，2： | 1 |
| 20 | The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4显示文摘 | HODGE M R ROONEY J M | 1996 | Cell1996，85，： | 1 |
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