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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Predictive value of plasma glucose level on admission for short and long term mortality in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention显示文摘 | Hoebers LP Damman P Claessen BE | 2012 | AmJ Cardiol2012，109，1： | 1 |
| 3 | Age-dependent impairment of endo-thelial progenitor cells is corrected by growth-hormone-mediated in-crease of insulin-like growth-faetor-1显示文摘 | Thum T Hoeber S Froese S | 2007 | Citc Ros2007，100，3： | 1 |
| 4 | Age-dependent impairment of endothelial progenitor cells is corrected by growthhormone-mediated increase of insulin-like growth-factor-1显示文摘 | Thum T Hoeber S Froese S | 2012 | Circulation Research2012，，： | 1 |
| 5 | Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulln-like growth-fac- tor-l显示文摘 | THUM T HOEBER S FROESE S | 2007 | Circ Res2007，100，3： | 1 |
| 6 | Age - dependent impairment of endothelial progenitor cells is corrected by growth - hormone - mediated increase of insulin - like growth - factor - I 显示文摘 | THUM T HOEBER S FROESE S | 2007 | Circ Res2007，100，3： | 1 |
| 7 | 99 Tcm Hynic-rh-Annexin V scintigraphy for in vivo imaging of apoptosis in patients with head and neck cancer treated with chemoradiotherapy显示文摘 | Hoebers F J Kartachova M de Bois J | 2008 | Eur J Nuel Med Mol Imaging2008，35，3： | 1 |
| 8 | Contemporary overview and clinical perspectives of chronic total occlusions 显示文摘 | Hoebers LP Claessen BE Dangas GD | 2014 | Nat Rev Cardiol2014，11，8： | 1 |
| 9 | Contemporary overview and clinical perspectives of chronic total occlusions 显示文摘 | Hoebers LP Claessen BE Dangas GD | 2014 | Nat Rev Cardiol2014，11，8： | 1 |
| 10 | Age-dependent im- pairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth- factor-1 显示文摘 | Thum T Hoeber S Froese S | 2007 | Circ Res2007，100，3： | 1 |
| 11 | Long-term clinical outcomes after percutaneous coronary intervention for chronic total occlusions in elderly patients(>/=75 years):five-year outcomes from a 1,791 patient multi-national registry显示文摘 | Hoebers LP Claessen BE Dangas GD | 2013 | Catheter Cardiovasc Interv2013，82，1： | 1 |
| 12 | Contemporary o verview and clinical perspectives of chronic total occlusions 显示文摘 | Hoebers LP Claessen BE Dangas GD | 2014 | Nat RevCardiol2014，11，8： | 1 |
| 13 | Evaluating WordBars in Exploratory Web Search Scenarios显示文摘 | Hoeber O | 2008 | Information Processing & Management2008，44，： | 1 |
| 14 | Meta-analysis on the im- pact of percutaneous coronary intervention of chronic total occlu- sions on left ventricular function and clinical outcome显示文摘 | Hoebers L P Claessen B E Elias J | 2015 | Int J Car- diol2015，187，： | 1 |
| 15 | 99mTc Hynic-rh-Annexin V scintigraphy for in vivo imaging of apoptosis in patients with head and neck cancer treated with chemoradiotherapy显示文摘 | Frank J. P. Hoebers Marina Kartachova Josien Bois Michiel W. M. Brekel Harm Tinteren Marcel Herk Coen R. N. Rasch Renato A. Valdés Olmos Marcel Verheij | 2008 | European Journal of Nuclear Medicine and Molecular Imaging2008，，3： | 1 |
| 16 | Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion显示文摘 | Matthijsen RA Huugen D Hoebers NT | 2007 | Am J Pathol2007，171，6： | 1 |
| 17 | Predictive value of plas- ma glucose level on admission for short and lung term mortality in patients with ST- elevation myocardial infarction treated with primary percutane- ous coronary intervention 显示文摘 | Hoebers LP Damman P Claessen BE | 2012 | Am J Cardiol2012，109，1： | 1 |
| 18 | In vivo imaging of apoptosis by 99m Tc-Annexin V scintigraphy: visual analysis in relation to treatment response显示文摘 | Marina Kartachova Rick L.M. Haas Renato A. Valdés Olmos Frank J.P. Hoebers Nico van Zandwijk Marcel Verheij | 2004 | Radiotherapy and Oncology2004，，3： | 1 |
| 19 | ^99mTc Hynic- rh-Annexin V scintigraphy for in vivo imaging of apoptosis in patients with head and neck cancer treated with chemora- diotherapy显示文摘 | Hoebers FJ Kartachova M de Bois J | 2008 | Eur J Nucl Med Mol Imaging2008，35，3： | 1 |
| 20 | Age-dependent impair- ment of endothelial progenitor cells is corrected by growth- hormone-mediated increase of insulin-like growth-factor-1 显示文摘 | Thum T Hoeber S Froese S | 2007 | Circ Res2007，100，3： | 1 |
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