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| 1 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 2 | Analysis of the dynamics in microactuators using high-speed cine photomicrography显示文摘 | Christian Rembe Bernd Tibken Eberhard P Hofer | 2001 | Journal of Microelectromechanical System2001，10，1： | 1 |
| 3 | Soluble TREM-1 is not suitable for distinguishing between systemic inflammatory response syndrome and sepsis survivors and non- survivors in the early stage of acute inflammation 显示文摘 | Christian Bopp Stefan Hofer Axel Bouchon | 2009 | Euro J Anaesthesiology2009，26，6： | 1 |
| 4 | New Ultradeformable Drug Carriers for Potential Transdermal Application of Interleukin-2 and Interferon-a Theoretic and Practical Aspects显示文摘 | Christian Hofer Rudolf Hartung Roland G?bel Petra Deering Antonie Lehmer Jürgen Breul | 2000 | World Journal of Surgery2000，，10： | 1 |
| 5 | Functional Electrical Stimulation (FES) of denervated muscles: existing and prospective technological solutions显示文摘 | Winfried Mayr Christian Hofer Manfred Bijak | 2002 | Basic Appl Myol2002，，12： | 1 |
| 6 | Characterization of Ba(Ti,Zr)O3 Ceramics Sintered under Reducing Conditions显示文摘 | Hofer Christiane Rene'Meyer Ulrich Bottger | 2004 | Journal of the European Ceramic Society2004，24，： | 1 |
| 7 | Gate-controlled dv/dt and di/ dt-limitation in high power IGBT converters显示文摘 | Christian Gerster Patrick Hofer | 1995 | EPE1995，5，3： | 1 |
| 8 | Association of the IL28B genotype with insulin resistance in patients with chronic hepatitis C显示文摘 | Albert Friedrich St?ttermayer Karoline Rutter Sandra Beinhardt Thomas-Matthias Scherzer Andreas Stadlmayr Harald Hofer Fritz Wrba Petra Steindl-Munda Michael Krebs Christian Datz Michael Trauner Peter Ferenci | 2012 | Journal of Hepatology2012，，3： | 1 |
| 9 | Hepatic steatosis in Wilson disease – Role of copper and PNPLA3 mutations显示文摘 | Albert Friedrich St?ttermayer Stefan Traussnigg Hans-Peter Dienes Elmar Aigner Rudolf Stauber Karoline Lackner Harald Hofer Judith Stift Friedrich Wrba Andreas Stadlmayr Christian Datz Michael Strasser Andreas Maieron Michael Trauner Peter Ferenci | 2015 | Journal of Hepatology2015，，1： | 1 |
| 10 | Analysis of the dynamics in microactuators using high-speed cine photomicrography显示文摘 | Bernd Tibken Eberhard P Hofer | 2001 | Journal of Microelectromechanical System2001，10，1： | 1 |
| 11 | Thermal ink jet dynamics:modeling,simulation,and testing显示文摘 | Rembe Christian Wiesche Stefan aus der Hofer Eberhard P | 2000 | Microelectron Reliab2000，40，3： | 1 |
| 12 | Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV-3a显示文摘 | Harald Hofer Hans C Bankl Friedrich Wrba Petra Steindl-Munda Markus Peck-Radosavljevic Christoph ?sterreicher Christian Mueller Alfred Gangl Peter Ferenci | 2002 | The American Journal of Gastroenterology2002，，11： | 1 |
| 13 | TGF-β1 codon 25 gene polymorphism is associated with cirrhosis in patients with hereditary hemochromatosis显示文摘 | Christoph H. ?sterreicher Christian Datz Felix Stickel Claus Hellerbrand Melitta Penz Harald Hofer Fritz Wrba Edward Penner Detlef Schuppan Peter Ferenci | 2005 | Cytokine2005，，2： | 1 |
| 14 | Effect of gender and ITPA polymorphisms on ribavirin-induced anemia in chronic hepatitis C patients显示文摘 | Thomas-Matthias Scherzer Albert Friedrich St?ttermayer Rudolf Stauber Andreas Maieron Michael Strasser Hermann Laferl Remy Schwarzer Christian Datz Karoline Rutter Sandra Beinhardt Petra Munda Harald Hofer Peter Ferenci | 2013 | Journal of Hepatology2013，，： | 1 |
| 15 | Circle of Willis variants are not associated with thrombectomy outcomes显示文摘Background The circle of Willis(COW)is part of the brain collateral system.The absence of COW segments may affect functional outcome in patients with ischaemic stroke undergoing endovascular therapy.Methods In 182 patients in the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 Study and the CT Perfusion to Predict Response to Recanalisation in Ischaemic Stroke Project,COW anatomy was evaluated on postinterventional magnetic resonance angiography.The absence of the posterior communicating artery or the first segments of posterior or anterior cerebral arteries ipsilateral to the ischaemic infarction was rated as an incomplete COW.Logistic regression was applied to evaluate an association with the patients’modified Rankin scale(mRS)at 90 days after stroke Results An incomplete ipsilateral COW was not predictive of the patients’mRS at 90 days after stroke.Significant associations were shown for the patients’baseline National Institutes of Health Stroke Scale(NIHSS),age and reperfusion status.The effect size suggests that a significant association of an incomplete COW with the mRS at 90 days may be obtained in cohorts of more than 3000 patients.Conclusions Compared with the established predictors NIHSS,age and reperfusion status,an incomplete COW is not associated with functional outcome after endovascular therapy. | Thomas Seifert-Held Katharina Eberhard Soren Christensen Edith Hofer Christian Enzinger Gregory W Albers Maarten Lansberg | 2021 | Stroke & Vascular Neurology2021，6，2： | 1 |
| 16 | The effect of lean production on financial performance: The mediating role of inventory leanness显示文摘 | Christian Hofer Cuneyt Eroglu Adriana Rossiter Hofer | 2012 | International Journal of Production Economics2012，，2： | 1 |
| 17 | Analysis of the dynamics in microactuators using high-speed cine photomicrography 显示文摘 | Christian Rembe Bernd Tibken Eberhard P Hofer | 2001 | Journal of Microelectromechanical System2001，10，1： | 1 |
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