|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis C virus genotypes distribution and transmission risk factors in Luxembourg from 1991 to 2006显示文摘AIM:To analyze the Hepatitis C virus (HCV) genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg. METHODS:Epidemiological information (gender, age and transmission risks) were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among whom 228 patients referred from prison. Genotyping using 5'noncoding (5'NC) sequencing was performed. We compared categorical data using the Fisher's exact F-test and odds ratios (OR) were calculated for evaluating association of HCV genotype and risk factors. RESULTS:The sex ratio was predominantly male (2.2) and individuals aged less than 40 years represented 49.6% of the population. Genotype 1 was predominant (53.4%) followed by genotype 3 (33%). Among risk factors, intravenous drug usage (IVDU) was the most frequently reported (71.4%) followed by medical-related transmission (17.6%) including haemophilia, transfusion recipients and other nosocomial reasons. Genotype 3 was significantly associated to IVDU (OR = 4.84, P < 0.0001) whereas genotype 1 was significantly associated with a medical procedure (OR = 2.42, P < 0.001). The HCV genotype distribution from inmate patients differed significantly from the rest of the population (Chi-square test with four degrees of freedom, P < 0.0001) with a higher frequency of genotype 3 (46.5% vs 27.5%) and a lower frequency of genotype 1 and 4 (44.7% vs 56.8% and 5.3% vs 9.6%, respectively). IVDU was nearly exclusively reported as a risk factor in prison. CONCLUSION:We report the first description of the HCV genotype distribution in Luxembourg. The repartition is similar to other European countries, with one of the highest European prevalence rates of genotype 3 (33%). Since serology screening became available in 1991, IVDU remains the most common way of HCV transmission in Luxembourg. | Francois Roman Karin Hawotte Daniel Struck Anne-Marie Ternes Jean-Yves Servais Vic Arendt Patrick Hoffman Robert Hemmer Thérèse Staub Carole Seguin-Devaux Jean-Claude Schmit | 2008 | World Journal of Gastroenterology2008，14，8： | 3 |
| 2 | Imprinting and expression of insulin- Ⅱ and H19 in normal breast tissue and breast tumor显示文摘 | Vu TH Hoffman AR | 1996 | J Clin Endocrinol Metab1996，81，4： | 1 |
| 3 | 查看详情显示文摘 | Landen O L Boehly T R Bradley D K Braun D G Callahan D A Celliers P M Collins G W Dewald E L Divol L Glenzer S H Hamza A Hicks D G Hoffman N Izumi N Jones O S Kirkwood R K Kyrala G A Michel P Milovich J Munro D H Nikroo A Olson R E Robey H F Spears B K Th | | 0，，： | 1 |
| 4 | Imprinting and expression of insulin-like growth factor-Ⅱ and H19 in normal breast tissue and breast tumor显示文摘 | Yballe CM Vu TH Hoffman AR | | 0，，04： | 1 |
| 5 | Imprinting and expres-sion of insulin-like growth factor-Ⅱ and H19 in normal breast tissue and breast tumor显示文摘 | Yballe CM Vu TH Hoffman AR | 1996 | J Clin Endocrinol Metab1996，81，4： | 1 |
| 6 | Reduced corticocortical connectivity can induce speech perception pathology and hallucinated ‘voices’显示文摘 | Hoffman RE McGlashan TH | 1998 | Schizophr Res1998，30，： | 1 |
| 7 | Comparison of lobectomy and wedge resection for carcinoma of the lung 显示文摘 | Hoffman TH Ransdell HT | 1980 | J Thorac Cardiovasc Surg1980，79，： | 1 |
| 8 | Promoter specific imprinting of human insulin like growth factor-Ⅱ gene显示文摘 | Vu TH Hoffman AR | 1994 | Nature1994，371，： | 1 |
| 9 | Imprinting and expression of insulin-like growth factor-Ⅱ and H19in normal breast tissue and breast tumor显示文摘 | Vu TH Hoffman AR | 1996 | J Clin Endocrinol Metab1996，81，4： | 1 |
| 10 | Early white discoloration of infantile hemangioma : a sign of impending ulceration 显示文摘 | Maguiness SM Hoffman WY McCalmont TH | 2010 | Arch Dennatol2010，146，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员