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| 1 | Early activation of inflammatory and immune response-related genes after experimental detachment of the porcine retina显示文摘 | Hollborn M Francke M landiev I | 2008 | Invest Ophthalmol Via Sci2008，49，3： | 1 |
| 2 | Proliferative gliosis causes misloeation and inactivation of inwardly rectifying K^+ (Kir) channels in rabbit retinal glial cells 显示文摘 | Ulbricht E Pannicke T Hollborn M | 2008 | Exp Eye Res2008，86，2： | 1 |
| 3 | Epression of LRPI in retinal pigment epithelial cells and its regulation by growth factors显示文摘 | Hollborn M Birkenmeier G Saalbach A | 2004 | Invest Ophthalnol Vis Sci2004，45，6： | 1 |
| 4 | Transcriptional regulation of aquaporin-3 in hu- man retinal pigment epithelial cells 显示文摘 | Hollborn M Ulbricht E Reichenbach A | 2012 | Mol Biol Rep2012，39，8： | 1 |
| 5 | Expression of LRP1 in retinal pigment epithelial cells and its regulation by growth factors显示文摘 | Hollborn M Birkenmeier G Saalbach A | 2004 | Invest Ophthalmol Vis Sci2004，45，： | 1 |
| 6 | Induction of cytokines in glial cells surrounding cortical β-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology显示文摘 | Gaby Mehlhorn Margrit Hollborn Reinhard Schliebs | 2000 | International Journal of Developmental Neuroscience2000，，4： | 1 |
| 7 | Retinal gene expression and Müller cell responses after branch retinal vein occlusion in the rat显示文摘 | Rehak M Hollborn M Iandiev I | 2009 | Invest Ophthalmol Vis Sei2009，50，： | 1 |
| 8 | Cellular signaling and factors involved in Müller cell gliosis: Neuroprotective and detrimental effects显示文摘 | Andreas Bringmann Ianors Iandiev Thomas Pannicke Antje Wurm Margrit Hollborn Peter Wiedemann Neville N. Osborne Andreas Reichenbach | 2009 | Progress in Retinal and Eye Research2009，，6： | 1 |
| 9 | Positive feedback regulation between MMP-9 and VEGF in human RPE cells显示文摘 | Hollborn M Stathopoulos C Steffen A | 2007 | Invest Ophthalmol Vis Sci2007，48，9： | 1 |
| 10 | Human retinal epithelium produces and responds to placenta growth factor 显示文摘 | Hollborn M Tenckhoff S Seifert M | 2006 | Graefes Arch Clin Exp Ophthalmol2006，244，6： | 1 |
| 11 | Expression of LRP1 in retinal pigment epithelial cells and its regulation by growth factors显示文摘 | Hollborn M Birkenmeier G Saalbach A | 2004 | Invest Ophthalmol Vis Sci2004，45，6： | 1 |
| 12 | Effective chemokines and cytokines in the rejection of human retinal pigment epithelium (RPE) cell grafts 显示文摘 | Enzmann V Kaufmann A Hollborn M Wiedemann P Gemsa D Kohen L | 1999 | Transpl Immunol1999，7，1： | 1 |
| 13 | Retinal gene expression andMuller cell responses after branch retinal vein occlusion in the ra显示文摘 | Rehak M Hollborn M Iandiev I | 2009 | Invest Ophthalmol Vis Sci2009，50，： | 1 |
| 14 | Glial cell expression of hepatocyte growth factor in vitreoretinal proliferative disease显示文摘 | Hollborn M Krausse C Iandiev I | 2004 | Lab Invest2004，84，8： | 1 |
| 15 | The influence of proinflammatory cytokines on human retinal pigment epithelium cell receptors显示文摘 | Hollborn M Kohen L Wiedemann P | 2001 | Greafe''s Arch Clin Exp Ophthalmol2001，239，4： | 1 |
| 16 | Minor influence of the immunosuppressive cytokines IL-10 and TGF-beta on the proliferation and apoptosis of human retinal pigment epithelial (RPE) cells in vitro 显示文摘 | Enzmann V Hollborn M Wiedemann P | 2001 | Ocul Immunol Inflamm2001，9，4： | 1 |
| 17 | Expression of LRP1 in retinal pigment epithelial cells and its regulation by growth factors显示文摘 | Hollborn M Birkenmeier G Saalbach A | 2004 | Invest Ophthalmol Vis Sci2004，45，6： | 1 |
| 18 | Characterixation of the basic fibroblast growth factor-evoked proliferation of the human Muller cell line,MIO-M1显示文摘 | Hollborn M Jahn K Limb GA | 2004 | Graefes Arch Clin Exp Ophthalmol2004，242，5： | 1 |
| 19 | Positive feedback regulation between MMP-9 and VEGF in human RPE cells 显示文摘 | Hollborn M Stathopoulos C Steffen A | 2007 | Invest Ophthalmol Visual Sci2007，48，9： | 1 |
| 20 | NOD2-and disease-specific gene expression profiles of peripheral blood mononuclear cells from Crohn's disease patients显示文摘AIM To investigate disease-specific gene expression profiles of peripheral blood mononuclear cells(PBMCs) from Crohn's disease(CD) patients in clinical remission.METHODS Patients with CD in clinical remission or with very low disease activity according to the Crohn's disease activity index were genotyped regarding nucleotidebinding oligomerization domain 2(NOD2),and PBMCs from wild-type(WT)-NOD2 patients,patients with homozygous or heterozygous NOD2 mutations and healthy donors were isolated for further analysis.The cells were cultured with vitamin D,peptidoglycan(PGN) and lipopolysaccharide(LPS) for defined periods of time before RNA was isolated and subjected to microarray analysis using Clariom S assays and quantitative realtime PCR.NOD2-and disease-specific gene expression profiles were evaluated with repeated measure ANOVA by a general linear model.RESULTS Employing microarray assays,a total of 267 genes were identified that were significantly up-or downregulated in PBMCs of WT-NOD2 patients,compared to healthy donors after challenge with vitamin D and/or a combination of LPS and PGN(P < 0.05;threshold:≥ 2-fold change).For further analysis by real-time PCR,genes with known impact on inflammation and immunity were selected that fulfilled predefined expression criteria.In a larger cohort of patients and controls,a disease-associated expression pattern,with higher transcript levels in vitamin D-treated PBMCs from patients,was observed for three of these genes,CLEC5 A(P < 0.030),lysozyme(LYZ;P < 0.047) and TREM1(P < 0.023).Six genes were found to be expressed in a NOD2-dependent manner(CD101,P < 0.002;CLEC5 A,P < 0.020;CXCL5,P < 0.009;IL-24,P < 0.044;ITGB2,P < 0.041;LYZ,P < 0.042).Interestingly,the highest transcript levels were observed in patients with heterozygous NOD2 mutations.CONCLUSION Our data identify CLEC5 A and LYZ as CD-and NOD2-associated genes of PBMCs and encourage further studies on their pathomechanistic roles. | Holger Schufler Maria Rohde Sarah Rohde Astrid Huth Nicole Gittel Hannes Hollborn Dirk Koczan Ane Glass Georg Lamprecht Robert Jaster | 2018 | World Journal of Gastroenterology2018，24，11： | 1 |
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