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| 1 | T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis显示文摘AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODS Magnetic resonance(MR) images were acquired from5 subjects scheduled for total knee arthroplasty(TKA)(mean age 70 years) and 20 young healthy control subjects without knee pain(mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained.Following TKA each condyle was divided into 4 parts(distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens(bone and cartilage blocks) were examined. For each joint,the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system.In magnetic resonance imaging(MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTS Eleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis(OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461;medial posterior condyle(MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550],suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage.Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA(P= 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients. CONCLUSION Though cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques. | Benjamin S Kester Philip M Carpenter Hon J Yu Taiki Nozaki Yasuhito Kaneko Hiroshi Yoshioka Ran Schwarzkopf | 2017 | World Journal of Orthopedics2017，8，4： | 12 |
| 2 | Evaluating the Performance of a Web Site via Queuing Theory显示文摘 | Chang Wenkui Hon S K | 2006 | Software Quality2006，2349，： | 1 |
| 3 | The pathogenesis of discogenic low back pain显示文摘 | Peng B Wu W Hon S | 2005 | J Bone Joint Surg2005，87，18： | 1 |
| 4 | Myocardin is a critical serum re- sponse factorcofactor in the transcriptional program regulating smooth muscle cell differentiation 显示文摘 | Kevin L Hon S Jian Li | 2003 | Mol Cell Biol2003，23，7： | 1 |
| 5 | Optimising build parameters for improved surface finish in stereolithography显示文摘 | ONUH S O HON K K B | 1998 | International Journal of Machine Tools & Manufacture1998，38，4： | 1 |
| 6 | Electronic evaluation of the fetal heart rate pattern preceding fetal death, further observation显示文摘 | Hon E H Lee S T | 1963 | Am J Obste Gyneeol1963，87，： | 1 |
| 7 | Aggressive angiomyxomain females:is radical resection the only option? 显示文摘 | Chan Y M Hon E Ngai S W | 2000 | Acta Obstet Gynecol Scand2000，79，3： | 1 |
| 8 | On-line evidence for spontaneous trait inferences at encoding显示文摘 | Uleman James S Hon Alex Roman Robert J Moskowitz Gordon B | 1996 | Personality and Social Psychology Bulletin1996，22，4： | 1 |
| 9 | Optimising build parameters for improved surface finish in stereolithography显示文摘 | Onuh S O Hon K K B | 1998 | International Journal of Machine Tools & Manufacture1998，38，4： | 1 |
| 10 | Hepatic arterial infu- sion of chemotherapy : the role of diagnostic and intervention- al radiology 显示文摘 | Ganeshan A Upponi S Hon LQ | 2008 | Ann Oncol2008，19，5： | 1 |
| 11 | Developing the Helsinki Smart City: The Role ofCompetitions for Open Data Applications显示文摘 | He nd r i k H ie l kem a Pa t r i z i a Hon g i s t o | 2013 | Journalof the K nowledge Economy2013，，6： | 1 |
| 12 | Synthesis of YAG:Ce phosphor via different aluminum sources and precipitation processes显示文摘 | Chiang C C Tsai M S Hsiao C S Hon M H | | 0，，： | 1 |
| 13 | Photodegradation and photoprotection of wood surface显示文摘 | CHANG S T HON D N S FEIST W C | 1982 | Wood and Fiber Science1982，14，2： | 1 |
| 14 | Mechanochemical process in cotton cellulose fiber显示文摘 | HON D N S SRINIVASAN K S V | 1983 | Journal of Applied Polymer Science1983，28，1： | 1 |
| 15 | Chemistry of Weathering and Protection Rowell RM显示文摘 | HON D N S | 1984 | Chemistry of Solid Wood1984，，： | 1 |
| 16 | Correlation of cytochrome P450 (CYP) 1A2 activity using caffeine phenotyping and olanzapine disposition in healthy volunteers 显示文摘 | Shirley K L Hon Y Y Penzak S R | 2003 | Neuropsychopharmacology2003，28，5： | 1 |
| 17 | Erythrocyte membrane fatty acids in patients with multiple sclerosis显示文摘 | Hon GM Hassan MS van Rensburg S J | 2009 | Mult Scler2009，15，： | 1 |
| 18 | The nesting of two - dimensional shapes using genetic algorithms 显示文摘 | Ismai 1 H S Hon K B | 1995 | Proc Inst Mech Engrs Part B1995，209，2： | 1 |
| 19 | Evaluation of microcrystalline cellulose I Changes in ultra-structural characteristics during preliminary acid hydrolysis显示文摘 | Tang L G Hon D N S Pan S H | 1998 | Journal of Apply Polymer Science1998，59，3： | 1 |
| 20 | Coercive strategy in interfirm cooperation: mediating roles of interpersonal and interorganizational trust显示文摘 | Lui S S Ngo H Hon A H Y | 2006 | Journal of Business Research2006，59，4： | 1 |
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